STRINGSTRING
KAT2B KAT2B SIRT7 SIRT7 SESN2 SESN2 POMC POMC GPT GPT PTH PTH LOC104656695 LOC104656695 DUSP12 DUSP12 PDK1 PDK1 RORA RORA USP7 USP7 TFF3 TFF3 CBFA2T3 CBFA2T3 ACTN3 ACTN3 FOXK2 FOXK2 ARPP19 ARPP19 AKT2 AKT2 INPP5K INPP5K FAM3A FAM3A WDR5 WDR5 PTK2B PTK2B GNMT GNMT NKX1-1 NKX1-1 PPP1R3D PPP1R3D FOXO1 FOXO1 DDB1 DDB1 GCGR GCGR TIGAR TIGAR RORC RORC PPP1R3E PPP1R3E SCARB2 SCARB2 GCG GCG ACACB ACACB NCOA2 NCOA2 GRB10 GRB10 PPP1CA PPP1CA SORBS1 SORBS1 PGAM1 PGAM1 SELENOS SELENOS NCOR1 NCOR1 NUPR1 NUPR1 MLYCD MLYCD PDK3 PDK3 INSR INSR PPP1R3A PPP1R3A ADCYAP1R1 ADCYAP1R1 C1QTNF6 C1QTNF6 LOC104666351 LOC104666351 AVPR1B AVPR1B SERPINA12 SERPINA12 C1QTNF1 C1QTNF1 FBP1 FBP1 PFKFB1 PFKFB1 P2RY1 P2RY1 EP300 EP300 KAT2A KAT2A PGP PGP FAM3C FAM3C RPTOR RPTOR ENSRROP00000026852 ENSRROP00000026852 TP53 TP53 SLC4A1 SLC4A1 NNMT NNMT IGF1 IGF1 PDK2 PDK2 LHCGR LHCGR MTOR MTOR ENSRROP00000024549 ENSRROP00000024549 HDAC4 HDAC4 PPP1R3F PPP1R3F PDK4 PDK4 GCK GCK ZNF692 ZNF692 GPER1 GPER1 CRY1 CRY1 CLK2 CLK2 PLEK PLEK MIDN MIDN GPLD1 GPLD1 ENPP1 ENPP1 SIRT1 SIRT1 BAD BAD LCMT1 LCMT1 LEPR LEPR PHKG2 PHKG2 SRC SRC IGFBP4 IGFBP4 FLCN FLCN STAT3 STAT3 LEP LEP ENSRROP00000018027 ENSRROP00000018027 IRS2 IRS2 FOXK1 FOXK1 MLST8 MLST8 PPARA PPARA GCKR GCKR PASK PASK ADIPOQ ADIPOQ DYRK2 DYRK2 DGKQ DGKQ COX11 COX11 ENSRROP00000012064 ENSRROP00000012064 ENSRROP00000011896 ENSRROP00000011896 CD244 CD244 SDHAF3 SDHAF3 C1QTNF3 C1QTNF3 IGF2 IGF2 OGT OGT PRKN PRKN NTSR1 NTSR1 ZMPSTE24 ZMPSTE24 DGAT2 DGAT2 PRKCE PRKCE ERFE ERFE MST1 MST1 C1QTNF12 C1QTNF12 MAS1 MAS1 DDIT4 DDIT4 FOXA2 FOXA2 GNB3 GNB3 SLC45A3 SLC45A3 STK11 STK11 RUBCNL RUBCNL PPP1R3C PPP1R3C GSK3A GSK3A EPM2AIP1 EPM2AIP1 PPP1R3B PPP1R3B PPARGC1A PPARGC1A AKT1 AKT1 GIT1 GIT1 SOGA1 SOGA1 BCKDK BCKDK IGFBP3 IGFBP3 P2RY6 P2RY6 PTPN2 PTPN2 SIRT6 SIRT6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (832 aa)
SIRT7Sirtuin 7. (400 aa)
SESN2Sestrin 2. (518 aa)
POMCProopiomelanocortin. (251 aa)
GPTGlutamic--pyruvic transaminase. (498 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
LOC104656695Uncharacterized protein. (229 aa)
DUSP12Dual specificity phosphatase 12. (340 aa)
PDK1Protein-serine/threonine kinase. (436 aa)
RORARAR related orphan receptor A. (555 aa)
USP7Uncharacterized protein; Belongs to the peptidase C19 family. (1102 aa)
TFF3Trefoil factor 3. (83 aa)
CBFA2T3CBFA2/RUNX1 partner transcriptional co-repressor 3. (653 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (959 aa)
FOXK2Forkhead box K2. (592 aa)
ARPP19cAMP regulated phosphoprotein 19; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. Belongs to the endosulfine family. (131 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
INPP5KInositol polyphosphate-5-phosphatase K. (456 aa)
FAM3AFamily with sequence similarity 3 member A. (244 aa)
WDR5WD repeat domain 5. (342 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1058 aa)
GNMTGlycine N-methyltransferase. (295 aa)
NKX1-1NK1 homeobox 1. (411 aa)
PPP1R3DProtein phosphatase 1 regulatory subunit. (299 aa)
FOXO1Forkhead box O1. (585 aa)
DDB1Damage specific DNA binding protein 1. (1147 aa)
GCGRGlucagon receptor; Belongs to the G-protein coupled receptor 2 family. (484 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (270 aa)
RORCRAR related orphan receptor C. (519 aa)
PPP1R3EProtein phosphatase 1 regulatory subunit 3E. (279 aa)
SCARB2Scavenger receptor class B member 2; Belongs to the CD36 family. (439 aa)
GCGGlucagon. (180 aa)
ACACBAcetyl-CoA carboxylase beta. (2442 aa)
NCOA2Nuclear receptor coactivator. (1475 aa)
GRB10Growth factor receptor bound protein 10. (593 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (367 aa)
SORBS1Sorbin and SH3 domain containing 1. (1294 aa)
PGAM1Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (254 aa)
SELENOSSelenoprotein S. (210 aa)
NCOR1Nuclear receptor corepressor 1. (2440 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (82 aa)
MLYCDMalonyl-CoA decarboxylase. (463 aa)
PDK3Protein-serine/threonine kinase. (415 aa)
INSRTyrosine-protein kinase receptor. (1370 aa)
PPP1R3AProtein phosphatase 1 regulatory subunit 3A. (1143 aa)
ADCYAP1R1ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family. (524 aa)
C1QTNF6C1q and TNF related 6. (278 aa)
LOC104666351UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (534 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (424 aa)
SERPINA12Serpin family A member 12; Belongs to the serpin family. (414 aa)
C1QTNF1C1q and TNF related 1. (290 aa)
FBP1Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (409 aa)
PFKFB16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1. (366 aa)
P2RY1Purinergic receptor P2Y1; Belongs to the G-protein coupled receptor 1 family. (373 aa)
EP300E1A binding protein p300. (2413 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (806 aa)
PGPUncharacterized protein. (122 aa)
FAM3CFamily with sequence similarity 3 member C. (227 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1335 aa)
ENSRROP00000026852Uncharacterized protein. (321 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
SLC4A1Anion exchange protein. (954 aa)
NNMTNicotinamide N-methyltransferase. (264 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (208 aa)
PDK2Protein-serine/threonine kinase. (559 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (699 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
ENSRROP00000024549Protein kinase domain-containing protein. (226 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1085 aa)
PPP1R3FProtein phosphatase 1 regulatory subunit 3F. (665 aa)
PDK4Protein-serine/threonine kinase. (411 aa)
GCKPhosphotransferase. (466 aa)
ZNF692Zinc finger protein 692. (524 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (341 aa)
CRY1Cryptochrome circadian regulator 1. (586 aa)
CLK2CDC like kinase 2; Belongs to the protein kinase superfamily. (497 aa)
PLEKPleckstrin. (350 aa)
MIDNMidnolin. (498 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (841 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase 1. (917 aa)
SIRT1Sirtuin 1. (746 aa)
BADBCL2 associated agonist of cell death. (167 aa)
LCMT1Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family. (334 aa)
LEPRLeptin receptor. (1163 aa)
PHKG2Phosphorylase kinase catalytic subunit gamma 2; Belongs to the protein kinase superfamily. (406 aa)
SRCTyrosine-protein kinase. (540 aa)
IGFBP4Insulin like growth factor binding protein 4. (258 aa)
FLCNFolliculin. (579 aa)
STAT3Signal transducer and activator of transcription. (802 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
ENSRROP00000018027Uncharacterized protein. (309 aa)
IRS2Insulin receptor substrate 2. (1006 aa)
FOXK1Forkhead box K1. (733 aa)
MLST8MTOR associated protein, LST8 homolog. (335 aa)
PPARAPeroxisome proliferator activated receptor alpha. (398 aa)
GCKRGlucokinase regulator. (621 aa)
PASKPAS domain containing serine/threonine kinase. (1328 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
DYRK2Dual specificity tyrosine phosphorylation regulated kinase 2. (590 aa)
DGKQDiacylglycerol kinase. (847 aa)
COX11Cytochrome c oxidase copper chaperone COX11. (276 aa)
ENSRROP00000012064Uncharacterized protein. (279 aa)
ENSRROP00000011896Tyrosine-protein phosphatase non-receptor type. (354 aa)
CD244CD244 molecule. (370 aa)
SDHAF3Uncharacterized protein. (125 aa)
C1QTNF3C1q domain-containing protein. (319 aa)
IGF2Insulin like growth factor 2. (236 aa)
OGTO-linked N-acetylglucosamine (GlcNAc) transferase. (1046 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
NTSR1Neurotensin receptor 1; Belongs to the G-protein coupled receptor 1 family. (418 aa)
ZMPSTE24Zinc metallopeptidase STE24. (515 aa)
DGAT2Diacylglycerol O-acyltransferase 2. (388 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
ERFEErythroferrone. (352 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. (752 aa)
C1QTNF12C1q and TNF related 12. (302 aa)
MAS1MAS1 proto-oncogene, G protein-coupled receptor; Belongs to the G-protein coupled receptor 1 family. (325 aa)
DDIT4DNA damage inducible transcript 4. (233 aa)
FOXA2Forkhead box A2. (457 aa)
GNB3G protein subunit beta 3. (340 aa)
SLC45A3Solute carrier family 45 member 3. (553 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
RUBCNLRubicon like autophagy enhancer. (663 aa)
PPP1R3CProtein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (317 aa)
GSK3AGlycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (428 aa)
EPM2AIP1EPM2A interacting protein 1. (607 aa)
PPP1R3BProtein phosphatase 1 regulatory subunit. (285 aa)
PPARGC1APPARG coactivator 1 alpha. (798 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
GIT1GIT ArfGAP 1. (763 aa)
SOGA1Suppressor of glucose, autophagy associated 1. (1456 aa)
BCKDKProtein-serine/threonine kinase. (412 aa)
IGFBP3Insulin like growth factor binding protein 3. (291 aa)
P2RY6Pyrimidinergic receptor P2Y6. (328 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (415 aa)
SIRT6Sirtuin 6. (355 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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