STRINGSTRING
OVOL2 OVOL2 GLIPR2 GLIPR2 CTNNB1 CTNNB1 PHLDB1 PHLDB1 LOC104682820 LOC104682820 FERMT2 FERMT2 EPHA4 EPHA4 SDHAF2 SDHAF2 FUZ FUZ TGFB1I1 TGFB1I1 BMP5 BMP5 BAMBI BAMBI SPRED1 SPRED1 NOG NOG DAB2 DAB2 ELL3 ELL3 IL17RD IL17RD FOXA2 FOXA2 SMAD3 SMAD3 ACVR1 ACVR1 WWTR1 WWTR1 ZNF750 ZNF750 TIAM1 TIAM1 TCF7L2 TCF7L2 ISL1 ISL1 RGCC RGCC ENG ENG BMP2 BMP2 POFUT2 POFUT2 GCNT2 GCNT2 MTOR MTOR PPP2CA PPP2CA OLFM1 OLFM1 TGFBR1 TGFBR1 ENSRROP00000024049 ENSRROP00000024049 SMAD2 SMAD2 GATA3 GATA3 PHLDB2 PHLDB2 EZH2 EZH2 MARK1 MARK1 HDAC2 HDAC2 HPN HPN SPRY2 SPRY2 PDPN PDPN SPRED2 SPRED2 PTEN PTEN JAG1 JAG1 AXIN2 AXIN2 MAD2L2 MAD2L2 TRIM62 TRIM62 CLASP2 CLASP2 EMP2 EMP2 PAWR PAWR SMAD4 SMAD4 MCRIP1 MCRIP1 COL1A1 COL1A1 ZNF703 ZNF703 TBX20 TBX20 SDCBP SDCBP MDK MDK TGFB2 TGFB2 LEF1 LEF1 BCL9L BCL9L TBX5 TBX5 IL1B IL1B ENSRROP00000035415 ENSRROP00000035415 ENSRROP00000035956 ENSRROP00000035956 LRG1 LRG1 BMP4 BMP4 SFRP1 SFRP1 LDLRAD4 LDLRAD4 CLASP1 CLASP1 EPHA3 EPHA3 DAG1 DAG1 TGFB1 TGFB1 SMAD7 SMAD7 NOTCH1 NOTCH1 SNAI1 SNAI1 SPRED3 SPRED3 EFNA1 EFNA1 CRB2 CRB2 DACT3 DACT3 SPRY1 SPRY1 VASN VASN DAB2IP DAB2IP ENSRROP00000000778 ENSRROP00000000778 TGFB3 TGFB3 IL6 IL6 BMP7 BMP7 SFRP2 SFRP2 ENSRROP00000003088 ENSRROP00000003088 TGFBR2 TGFBR2 LOXL2 LOXL2 ALX1 ALX1 NKX2-1 NKX2-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
OVOL2Ovo like zinc finger 2. (275 aa)
GLIPR2GLI pathogenesis related 2; Belongs to the CRISP family. (165 aa)
CTNNB1Catenin beta 1. (781 aa)
PHLDB1Pleckstrin homology like domain family B member 1. (1532 aa)
LOC104682820Uncharacterized protein. (143 aa)
FERMT2Fermitin family member 2. (695 aa)
EPHA4EPH receptor A4. (986 aa)
SDHAF2Succinate dehydrogenase assembly factor 2, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. (166 aa)
FUZFuzzy planar cell polarity protein. (418 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (456 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
SPRED1Sprouty related EVH1 domain containing 1. (444 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
DAB2DAB adaptor protein 2. (749 aa)
ELL3Elongation factor for RNA polymerase II 3. (397 aa)
IL17RDInterleukin 17 receptor D. (738 aa)
FOXA2Forkhead box A2. (457 aa)
SMAD3Mothers against decapentaplegic homolog. (480 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
ZNF750Zinc finger protein 750. (724 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1591 aa)
TCF7L2Transcription factor 7 like 2. (555 aa)
ISL1ISL LIM homeobox 1. (349 aa)
RGCCRegulator of cell cycle. (134 aa)
ENGEndoglin. (658 aa)
BMP2Bone morphogenetic protein 2. (470 aa)
POFUT2Protein O-fucosyltransferase 2. (429 aa)
GCNT2Glucosaminyl (N-acetyl) transferase 2 (I blood group). (402 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
OLFM1Olfactomedin 1. (485 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (498 aa)
ENSRROP00000024049Uncharacterized protein. (262 aa)
SMAD2Mothers against decapentaplegic homolog. (392 aa)
GATA3GATA binding protein 3. (444 aa)
PHLDB2Pleckstrin homology like domain family B member 2. (1306 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (737 aa)
MARK1Non-specific serine/threonine protein kinase. (796 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
HPNHepsin; Belongs to the peptidase S1 family. (417 aa)
SPRY2Sprouty RTK signaling antagonist 2. (338 aa)
PDPNPodoplanin. (220 aa)
SPRED2Sprouty related EVH1 domain containing 2. (432 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
AXIN2Axin 2. (843 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (224 aa)
TRIM62Tripartite motif containing 62. (470 aa)
CLASP2Uncharacterized protein. (1517 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
PAWRPro-apoptotic WT1 regulator. (340 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
MCRIP1MAPK regulated corepressor interacting protein 1. (119 aa)
COL1A1Collagen type I alpha 1 chain. (1464 aa)
ZNF703Zinc finger protein 703. (585 aa)
TBX20T-box transcription factor 20. (447 aa)
SDCBPSyndecan binding protein. (318 aa)
MDKUncharacterized protein. (143 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
BCL9LBCL9 like. (1500 aa)
TBX5T-box transcription factor 5. (518 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
ENSRROP00000035415PDZ domain-containing protein. (278 aa)
ENSRROP00000035956Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (184 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (347 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
LDLRAD4Low density lipoprotein receptor class A domain containing 4. (306 aa)
CLASP1Cytoplasmic linker associated protein 1. (1552 aa)
EPHA3EPH receptor A3. (984 aa)
DAG1Dystroglycan 1. (894 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
SMAD7MH2 domain-containing protein. (211 aa)
NOTCH1Notch receptor 1. (2560 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
SPRED3Sprouty related EVH1 domain containing 3. (442 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (205 aa)
CRB2Crumbs cell polarity complex component 2. (1287 aa)
DACT3Dishevelled binding antagonist of beta catenin 3. (571 aa)
SPRY1Sprouty RTK signaling antagonist 1. (319 aa)
VASNVasorin. (673 aa)
DAB2IPDAB2 interacting protein. (1189 aa)
ENSRROP00000000778PDZ_6 domain-containing protein. (212 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
IL6Interleukin 6. (214 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
ENSRROP00000003088Uncharacterized protein. (104 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
LOXL2Lysyl oxidase like 2. (452 aa)
ALX1ALX homeobox 1. (326 aa)
NKX2-1NK2 homeobox 1. (401 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.