STRINGSTRING
BMP7 BMP7 ENSRROP00000024049 ENSRROP00000024049 TGFBR1 TGFBR1 OLFM1 OLFM1 MTOR MTOR GCNT2 GCNT2 TGFB1I1 TGFB1I1 LOC104682820 LOC104682820 CTNNB1 CTNNB1 GLIPR2 GLIPR2 TBX20 TBX20 SDCBP SDCBP MDK MDK TGFB2 TGFB2 LEF1 LEF1 BCL9L BCL9L IL1B IL1B ENSRROP00000035415 ENSRROP00000035415 ENSRROP00000035956 ENSRROP00000035956 LRG1 LRG1 BMP4 BMP4 TGFB1 TGFB1 NOTCH1 NOTCH1 SNAI1 SNAI1 CRB2 CRB2 ZNF703 ZNF703 COL1A1 COL1A1 SMAD4 SMAD4 EMP2 EMP2 BAMBI BAMBI RGCC RGCC ENSRROP00000000778 ENSRROP00000000778 TGFB3 TGFB3 IL6 IL6 SMAD2 SMAD2 ENSRROP00000003088 ENSRROP00000003088 TGFBR2 TGFBR2 LOXL2 LOXL2 ALX1 ALX1 DAB2 DAB2 SMAD3 SMAD3 ACVR1 ACVR1 WWTR1 WWTR1 TIAM1 TIAM1 TCF7L2 TCF7L2 ISL1 ISL1 ENG ENG BMP2 BMP2 FERMT2 FERMT2 AXIN2 AXIN2 JAG1 JAG1 PDPN PDPN HDAC2 HDAC2 EZH2 EZH2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BMP7Bone morphogenetic protein 7. (431 aa)
ENSRROP00000024049Uncharacterized protein. (262 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (498 aa)
OLFM1Olfactomedin 1. (485 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
GCNT2Glucosaminyl (N-acetyl) transferase 2 (I blood group). (402 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (456 aa)
LOC104682820Uncharacterized protein. (143 aa)
CTNNB1Catenin beta 1. (781 aa)
GLIPR2GLI pathogenesis related 2; Belongs to the CRISP family. (165 aa)
TBX20T-box transcription factor 20. (447 aa)
SDCBPSyndecan binding protein. (318 aa)
MDKUncharacterized protein. (143 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
BCL9LBCL9 like. (1500 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
ENSRROP00000035415PDZ domain-containing protein. (278 aa)
ENSRROP00000035956Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (184 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (347 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
NOTCH1Notch receptor 1. (2560 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
CRB2Crumbs cell polarity complex component 2. (1287 aa)
ZNF703Zinc finger protein 703. (585 aa)
COL1A1Collagen type I alpha 1 chain. (1464 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
RGCCRegulator of cell cycle. (134 aa)
ENSRROP00000000778PDZ_6 domain-containing protein. (212 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
IL6Interleukin 6. (214 aa)
SMAD2Mothers against decapentaplegic homolog. (392 aa)
ENSRROP00000003088Uncharacterized protein. (104 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
LOXL2Lysyl oxidase like 2. (452 aa)
ALX1ALX homeobox 1. (326 aa)
DAB2DAB adaptor protein 2. (749 aa)
SMAD3Mothers against decapentaplegic homolog. (480 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1591 aa)
TCF7L2Transcription factor 7 like 2. (555 aa)
ISL1ISL LIM homeobox 1. (349 aa)
ENGEndoglin. (658 aa)
BMP2Bone morphogenetic protein 2. (470 aa)
FERMT2Fermitin family member 2. (695 aa)
AXIN2Axin 2. (843 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
PDPNPodoplanin. (220 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (737 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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