81 items (Rhinopithecus roxellana) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSRROP00000016954	Miff domain-containing protein. (78 aa)
	MMP9	Matrix metallopeptidase 9. (703 aa)
	FBXO7	F-box protein 7. (522 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (230 aa)
	ADCK1	AarF domain containing kinase 1. (523 aa)
	RALBP1	RalA binding protein 1. (655 aa)
	SIVA1	Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl- x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. (175 aa)
	PRKN	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
	VPS13D	Vacuolar protein sorting 13 homolog D. (4376 aa)
	GZMB	Granzyme B; Belongs to the peptidase S1 family. (281 aa)
	CAMKK2	Calcium/calmodulin dependent protein kinase kinase 2. (588 aa)
	ENSRROP00000043193	Protein kinase domain-containing protein. (377 aa)
	MCU	Mitochondrial calcium uniporter. (351 aa)
	PARK7	Parkinsonism associated deglycase. (189 aa)
	MARCHF5	Membrane associated ring-CH-type finger 5. (278 aa)
	MIEF1	Mitochondrial elongation factor 1. (472 aa)
	PYCARD	PYD and CARD domain containing. (195 aa)
	ENSRROP00000038550	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (326 aa)
	BMF	Bcl2 modifying factor. (184 aa)
	PLD6	Phospholipase D family member 6. (224 aa)
	DNM1L	Dynamin 1 like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (752 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (309 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (826 aa)
	BAK1	BCL2 antagonist/killer 1. (211 aa)
	ENSRROP00000000635	Uncharacterized protein. (260 aa)
	ENSRROP00000001540	Miff domain-containing protein. (81 aa)
	PPARGC1A	PPARG coactivator 1 alpha. (798 aa)
	MAPK8	Mitogen-activated protein kinase. (427 aa)
	STOML2	Stomatin like 2. (356 aa)
	ZNF205	Zinc finger protein 205. (554 aa)
	GSK3A	Glycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (428 aa)
	FIS1	Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa)
	MGARP	Mitochondria localized glutamic acid rich protein. (218 aa)
	VDAC1	Voltage dependent anion channel 1. (283 aa)
	MOAP1	Modulator of apoptosis 1. (351 aa)
	BAX	BCL2 associated X, apoptosis regulator. (197 aa)
	ENSRROP00000007609	DJ-1_PfpI domain-containing protein. (153 aa)
	TNFSF10	Tumor necrosis factor ligand superfamily member. (281 aa)
	MUL1	Mitochondrial E3 ubiquitin protein ligase 1. (352 aa)
	ZDHHC6	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (413 aa)
	SSBP1	Single stranded DNA binding protein 1. (148 aa)
	HTRA2	HtrA serine peptidase 2. (458 aa)
	ENSRROP00000036868	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (406 aa)
	LOC104675025	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (373 aa)
	BBC3	BCL2 binding component 3. (261 aa)
	VPS35	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (796 aa)
	DDHD2	DDHD domain containing 2. (711 aa)
	AURKA	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (403 aa)
	HTT	Huntingtin. (3100 aa)
	PINK1	PTEN induced kinase 1. (581 aa)
	RALA	RAS like proto-oncogene A. (206 aa)
	MIEF2	Mitochondrial elongation factor 2. (465 aa)
	LOC104658716	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (248 aa)
	BIK	BCL2 interacting killer. (157 aa)
	HIP1R	Huntingtin interacting protein 1 related. (1289 aa)
	MAPK10	Mitogen-activated protein kinase. (550 aa)
	BCL2L11	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
	ENSRROP00000025179	Rho-GAP domain-containing protein. (543 aa)
	BOK	BCL2 family apoptosis regulator BOK. (212 aa)
	ATP5IF1	ATP synthase inhibitory factor subunit 1. (136 aa)
	KDR	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
	PPIF	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (206 aa)
	DDHD1	DDHD domain containing 1. (933 aa)
	BID	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (226 aa)
	GPER1	G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (341 aa)
	PGAM5	PGAM family member 5, mitochondrial serine/threonine protein phosphatase. (260 aa)
	SLC25A4	Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
	PLA2G6	Phospholipase A2 group VI. (806 aa)
	BNIP3	BCL2 interacting protein 3. (194 aa)
	CIDEB	Cell death inducing DFFA like effector b. (219 aa)
	AMBRA1	Autophagy and beclin 1 regulator 1. (1298 aa)
	CHCHD10	Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial. (95 aa)
	ENSRROP00000021317	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (374 aa)
	BAD	BCL2 associated agonist of cell death. (167 aa)
	MFF	Mitochondrial fission factor. (342 aa)
	DCN	Decorin; May affect the rate of fibrils formation. (359 aa)
	SPIRE1	Spire type actin nucleation factor 1. (695 aa)
	ENSRROP00000017799	Rho-GAP domain-containing protein. (587 aa)
	FAM162A	Family with sequence similarity 162 member A. (155 aa)
	ENSRROP00000017324	Uncharacterized protein. (258 aa)

Your Current Organism:

Rhinopithecus roxellana

NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMBRA1	PRKN	ENSRROP00000021502	ENSRROP00000010084	Autophagy and beclin 1 regulator 1.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	0.956
AURKA	TP53	ENSRROP00000033049	ENSRROP00000026843	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.712
BAD	BAK1	ENSRROP00000020214	ENSRROP00000000518	BCL2 associated agonist of cell death.	BCL2 antagonist/killer 1.	0.825
BAD	BAX	ENSRROP00000020214	ENSRROP00000007221	BCL2 associated agonist of cell death.	BCL2 associated X, apoptosis regulator.	0.785
BAD	BCL2L11	ENSRROP00000020214	ENSRROP00000028595	BCL2 associated agonist of cell death.	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	0.746
BAD	BID	ENSRROP00000020214	ENSRROP00000023719	BCL2 associated agonist of cell death.	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	0.607
BAD	BOK	ENSRROP00000020214	ENSRROP00000025156	BCL2 associated agonist of cell death.	BCL2 family apoptosis regulator BOK.	0.736
BAD	MAPK10	ENSRROP00000020214	ENSRROP00000028817	BCL2 associated agonist of cell death.	Mitogen-activated protein kinase.	0.953
BAD	MAPK8	ENSRROP00000020214	ENSRROP00000004414	BCL2 associated agonist of cell death.	Mitogen-activated protein kinase.	0.954
BAK1	BAD	ENSRROP00000000518	ENSRROP00000020214	BCL2 antagonist/killer 1.	BCL2 associated agonist of cell death.	0.825
BAK1	BAX	ENSRROP00000000518	ENSRROP00000007221	BCL2 antagonist/killer 1.	BCL2 associated X, apoptosis regulator.	0.971
BAK1	BBC3	ENSRROP00000000518	ENSRROP00000034309	BCL2 antagonist/killer 1.	BCL2 binding component 3.	0.673
BAK1	BCL2L11	ENSRROP00000000518	ENSRROP00000028595	BCL2 antagonist/killer 1.	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	0.941
BAK1	BID	ENSRROP00000000518	ENSRROP00000023719	BCL2 antagonist/killer 1.	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	0.967
BAK1	BIK	ENSRROP00000000518	ENSRROP00000029169	BCL2 antagonist/killer 1.	BCL2 interacting killer.	0.559
BAK1	BMF	ENSRROP00000000518	ENSRROP00000038184	BCL2 antagonist/killer 1.	Bcl2 modifying factor.	0.586
BAK1	ENSRROP00000000635	ENSRROP00000000518	ENSRROP00000000635	BCL2 antagonist/killer 1.	Uncharacterized protein.	0.492
BAK1	ENSRROP00000017324	ENSRROP00000000518	ENSRROP00000017324	BCL2 antagonist/killer 1.	Uncharacterized protein.	0.492
BAK1	PPIF	ENSRROP00000000518	ENSRROP00000024559	BCL2 antagonist/killer 1.	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.413
BAK1	PYCARD	ENSRROP00000000518	ENSRROP00000039913	BCL2 antagonist/killer 1.	PYD and CARD domain containing.	0.584