(35 nodes) Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum network (Rhinopithecus roxellana)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	TMEM38B	Transmembrane protein 38B. (276 aa)
	CAMK2D	Calcium/calmodulin dependent protein kinase II delta. (533 aa)
	CHD7	Chromodomain helicase DNA binding protein 7. (2998 aa)
	ENSRROP00000004937	EF-hand domain-containing protein; Belongs to the calmodulin family. (79 aa)
	PLN	Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
	PDE4D	Phosphodiesterase. (585 aa)
	LOC104675649	Uncharacterized protein; Belongs to the GST superfamily. (240 aa)
	SLC8A1	Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
	LOC104672524	Uncharacterized protein. (310 aa)
	TRDN	Triadin. (600 aa)
	FKBP1B	Peptidylprolyl isomerase. (108 aa)
	METTL21C	Methyltransferase like 21C. (264 aa)
	ANK2	Ankyrin 2. (3938 aa)
	GSTO1	Uncharacterized protein; Belongs to the GST superfamily. (241 aa)
	LOC104660236	Uncharacterized protein. (460 aa)
	CASQ2	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (400 aa)
	CALM2	Uncharacterized protein; Belongs to the calmodulin family. (186 aa)
	CALM3	Calmodulin 1; Belongs to the calmodulin family. (149 aa)
	ENSRROP00000019238	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (785 aa)
	ENSRROP00000019711	PDE4_UCR domain-containing protein. (158 aa)
	ENSRROP00000019822	Uncharacterized protein; Belongs to the calmodulin family. (141 aa)
	DMD	ZZ-type domain-containing protein. (635 aa)
	ENSRROP00000027041	Uncharacterized protein; Belongs to the calmodulin family. (70 aa)
	ENSRROP00000027051	GST C-terminal domain-containing protein. (218 aa)
	LOC104675852	Uncharacterized protein; Belongs to the GST superfamily. (241 aa)
	ENSRROP00000028305	Uncharacterized protein; Belongs to the calmodulin family. (167 aa)
	CACNA1C	Ca_chan_IQ domain-containing protein. (829 aa)
	RYR2	Ryanodine receptor 2. (4938 aa)
	CALM1	Calmodulin 1. (149 aa)
	HRC	Histidine rich calcium binding protein. (839 aa)
	ASPH	Aspartate beta-hydroxylase. (762 aa)
	CASQ1	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (399 aa)
	DHRS7C	Dehydrogenase/reductase 7C; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (324 aa)
	AKAP6	A-kinase anchoring protein 6. (2246 aa)
	CLIC2	Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (247 aa)

Your Current Organism:

Rhinopithecus roxellana

NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKAP6	ENSRROP00000019711	ENSRROP00000043483	ENSRROP00000019711	A-kinase anchoring protein 6.	PDE4_UCR domain-containing protein.	0.473
AKAP6	FKBP1B	ENSRROP00000043483	ENSRROP00000012166	A-kinase anchoring protein 6.	Peptidylprolyl isomerase.	0.580
AKAP6	PDE4D	ENSRROP00000043483	ENSRROP00000006602	A-kinase anchoring protein 6.	Phosphodiesterase.	0.473
AKAP6	RYR2	ENSRROP00000043483	ENSRROP00000035727	A-kinase anchoring protein 6.	Ryanodine receptor 2.	0.758
ASPH	CASQ1	ENSRROP00000039218	ENSRROP00000039711	Aspartate beta-hydroxylase.	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.973
ASPH	CASQ2	ENSRROP00000039218	ENSRROP00000016492	Aspartate beta-hydroxylase.	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.972
ASPH	FKBP1B	ENSRROP00000039218	ENSRROP00000012166	Aspartate beta-hydroxylase.	Peptidylprolyl isomerase.	0.692
ASPH	RYR2	ENSRROP00000039218	ENSRROP00000035727	Aspartate beta-hydroxylase.	Ryanodine receptor 2.	0.967
ASPH	TRDN	ENSRROP00000039218	ENSRROP00000010948	Aspartate beta-hydroxylase.	Triadin.	0.907
CACNA1C	CALM1	ENSRROP00000028996	ENSRROP00000038292	Ca_chan_IQ domain-containing protein.	Calmodulin 1.	0.420
CACNA1C	CALM2	ENSRROP00000028996	ENSRROP00000019123	Ca_chan_IQ domain-containing protein.	Uncharacterized protein; Belongs to the calmodulin family.	0.420
CACNA1C	CALM3	ENSRROP00000028996	ENSRROP00000019127	Ca_chan_IQ domain-containing protein.	Calmodulin 1; Belongs to the calmodulin family.	0.939
CACNA1C	CAMK2D	ENSRROP00000028996	ENSRROP00000000255	Ca_chan_IQ domain-containing protein.	Calcium/calmodulin dependent protein kinase II delta.	0.703
CACNA1C	ENSRROP00000004937	ENSRROP00000028996	ENSRROP00000004937	Ca_chan_IQ domain-containing protein.	EF-hand domain-containing protein; Belongs to the calmodulin family.	0.420
CACNA1C	ENSRROP00000019238	ENSRROP00000028996	ENSRROP00000019238	Ca_chan_IQ domain-containing protein.	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.	0.940
CACNA1C	ENSRROP00000019822	ENSRROP00000028996	ENSRROP00000019822	Ca_chan_IQ domain-containing protein.	Uncharacterized protein; Belongs to the calmodulin family.	0.939
CACNA1C	ENSRROP00000027041	ENSRROP00000028996	ENSRROP00000027041	Ca_chan_IQ domain-containing protein.	Uncharacterized protein; Belongs to the calmodulin family.	0.420
CACNA1C	ENSRROP00000028305	ENSRROP00000028996	ENSRROP00000028305	Ca_chan_IQ domain-containing protein.	Uncharacterized protein; Belongs to the calmodulin family.	0.420
CACNA1C	RYR2	ENSRROP00000028996	ENSRROP00000035727	Ca_chan_IQ domain-containing protein.	Ryanodine receptor 2.	0.581
CALM1	CACNA1C	ENSRROP00000038292	ENSRROP00000028996	Calmodulin 1.	Ca_chan_IQ domain-containing protein.	0.420