42 items (Rhinopithecus roxellana) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FHOD1	Formin homology 2 domain containing 1. (1185 aa)
	MYH1	Myosin heavy chain 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1938 aa)
	RANGRF	RAN guanine nucleotide release factor. (186 aa)
	SPTBN4	Spectrin beta chain; Belongs to the spectrin family. (2446 aa)
	DES	Desmin; Belongs to the intermediate filament family. (506 aa)
	ANK2	Ankyrin 2. (3938 aa)
	DLG1	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (926 aa)
	LOC104671825	Uncharacterized protein. (168 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	LOC104657019	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (396 aa)
	SCN5A	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2016 aa)
	SLC8A1	Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
	NRAP	Nebulin related anchoring protein. (1731 aa)
	PKP2	Plakophilin 2. (882 aa)
	CTNNA1	Catenin alpha 1. (906 aa)
	GJA5	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
	KCNA5	Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (605 aa)
	SCN4B	Sodium voltage-gated channel beta subunit 4. (228 aa)
	PAK1	Non-specific serine/threonine protein kinase. (555 aa)
	ENSRROP00000043831	Uncharacterized protein. (73 aa)
	AKAP6	A-kinase anchoring protein 6. (2246 aa)
	OBSL1	Obscurin like 1. (1627 aa)
	SCN1B	Sodium voltage-gated channel beta subunit 1. (245 aa)
	DSG2	Desmoglein 2. (1118 aa)
	YWHAH	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (246 aa)
	CDH2	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (875 aa)
	SCN2A	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2005 aa)
	FGF13	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (245 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	SCN1A	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2008 aa)
	DSC2	Desmocollin 2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (901 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	DSP	Desmoplakin. (2871 aa)
	FXYD1	FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (67 aa)
	TMEM65	Transmembrane protein 65. (236 aa)
	ANK3	Ankyrin 3. (4381 aa)
	TJP1	Tight junction protein 1; Belongs to the MAGUK family. (1756 aa)
	SLC2A1	Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (506 aa)
	JUP	Junction plakoglobin. (760 aa)
	PGM5	Phosphoglucomutase 5; Belongs to the phosphohexose mutase family. (511 aa)
	SLC9A1	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
	VCL	Vinculin. (1134 aa)

Your Current Organism:

Rhinopithecus roxellana

NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANK2	ANK3	ENSRROP00000015005	ENSRROP00000002343	Ankyrin 2.	Ankyrin 3.	0.911
ANK2	OBSL1	ENSRROP00000015005	ENSRROP00000041409	Ankyrin 2.	Obscurin like 1.	0.444
ANK2	SCN2A	ENSRROP00000015005	ENSRROP00000034489	Ankyrin 2.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.426
ANK2	SCN4B	ENSRROP00000015005	ENSRROP00000044649	Ankyrin 2.	Sodium voltage-gated channel beta subunit 4.	0.425
ANK2	SCN5A	ENSRROP00000015005	ENSRROP00000010812	Ankyrin 2.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.488
ANK2	SPTBN4	ENSRROP00000015005	ENSRROP00000016782	Ankyrin 2.	Spectrin beta chain; Belongs to the spectrin family.	0.907
ANK3	ANK2	ENSRROP00000002343	ENSRROP00000015005	Ankyrin 3.	Ankyrin 2.	0.911
ANK3	SCN1A	ENSRROP00000002343	ENSRROP00000029355	Ankyrin 3.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.438
ANK3	SCN2A	ENSRROP00000002343	ENSRROP00000034489	Ankyrin 3.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.657
ANK3	SCN5A	ENSRROP00000002343	ENSRROP00000010812	Ankyrin 3.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.748
ANK3	SPTBN4	ENSRROP00000002343	ENSRROP00000016782	Ankyrin 3.	Spectrin beta chain; Belongs to the spectrin family.	0.952
CAV3	CTNNB1	ENSRROP00000004131	ENSRROP00000030288	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Catenin beta 1.	0.468
CAV3	DLG1	ENSRROP00000004131	ENSRROP00000013368	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family.	0.622
CAV3	JUP	ENSRROP00000004131	ENSRROP00000023676	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Junction plakoglobin.	0.464
CAV3	LOC104657019	ENSRROP00000004131	ENSRROP00000011685	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.417
CAV3	SCN4B	ENSRROP00000004131	ENSRROP00000044649	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Sodium voltage-gated channel beta subunit 4.	0.485
CAV3	SCN5A	ENSRROP00000004131	ENSRROP00000010812	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.592
CDH2	CTNNA1	ENSRROP00000035957	ENSRROP00000000621	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins.	Catenin alpha 1.	0.856
CDH2	CTNNB1	ENSRROP00000035957	ENSRROP00000030288	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins.	Catenin beta 1.	0.979
CDH2	DSP	ENSRROP00000035957	ENSRROP00000028648	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins.	Desmoplakin.	0.506