STRINGSTRING
STAR STAR LOC104660718 LOC104660718 CAT CAT ENSRROP00000001042 ENSRROP00000001042 ERLIN2 ERLIN2 ABCA5 ABCA5 PLPP6 PLPP6 LOC104670080 LOC104670080 ANGPTL3 ANGPTL3 INSIG2 INSIG2 HSD17B7 HSD17B7 IDI2 IDI2 HNF1A HNF1A CH25H CH25H MT3 MT3 CYP46A1 CYP46A1 CFTR CFTR CYP8B1 CYP8B1 CYP19A1 CYP19A1 CYP1B1 CYP1B1 LDLR LDLR CYP51A1 CYP51A1 APOA2 APOA2 CYP26C1 CYP26C1 PPARD PPARD APOE APOE SULT1C3 SULT1C3 SCAP SCAP PRKAG2 PRKAG2 PON1 PON1 NSDHL NSDHL CYP3A4 CYP3A4 LOC104671485 LOC104671485 ARV1 ARV1 PIP4P1 PIP4P1 LIPE LIPE LIMA1 LIMA1 LOC104674109 LOC104674109 CYB5R2 CYB5R2 TSKU TSKU CYP1A2 CYP1A2 SQLE SQLE SREBF2 SREBF2 CYP7A1 CYP7A1 INSIG1 INSIG1 ENSRROP00000017642 ENSRROP00000017642 LOC104670158 LOC104670158 CLN6 CLN6 ENSRROP00000017967 ENSRROP00000017967 VLDLR VLDLR G6PD G6PD LEP LEP CLN8 CLN8 GBA2 GBA2 LEPR LEPR SCARB1 SCARB1 SULT2A1 SULT2A1 HDLBP HDLBP HMGCS2 HMGCS2 CYB5R3 CYB5R3 APOB APOB MVD MVD LIPC LIPC CUBN CUBN NPC1 NPC1 CYP39A1 CYP39A1 SOAT1 SOAT1 CYB5R1 CYB5R1 ENSRROP00000023708 ENSRROP00000023708 LOC104671477 LOC104671477 SC5D SC5D FDX1 FDX1 LRP5 LRP5 PMVK PMVK CYP11A1 CYP11A1 CYP27A1 CYP27A1 CYP11B1 CYP11B1 NPC2 NPC2 CDCP2 CDCP2 ENSRROP00000028937 ENSRROP00000028937 PRKAA1 PRKAA1 TM7SF2 TM7SF2 ABCA1 ABCA1 LOC104665604 LOC104665604 SREBF1 SREBF1 LOC104660506 LOC104660506 APOF APOF FDPS FDPS GBA GBA PMP22 PMP22 CYP7B1 CYP7B1 HMGCR HMGCR CETP CETP APP APP PRKAA2 PRKAA2 LSS LSS SMPD1 SMPD1 PCSK9 PCSK9 LCAT LCAT LBR LBR CYP26B1 CYP26B1 NPC1L1 NPC1L1 LDLRAP1 LDLRAP1 DISP3 DISP3 APOA5 APOA5 MBTPS1 MBTPS1 SULT2B1 SULT2B1 MVK MVK TMEM130 TMEM130 DHCR24 DHCR24 CYP4V2 CYP4V2 IDI1 IDI1 DHCR7 DHCR7 FDXR FDXR OSBPL5 OSBPL5 CYP26A1 CYP26A1 MSMO1 MSMO1 ERLIN1 ERLIN1 NR0B2 NR0B2 AKR1D1 AKR1D1 SOAT2 SOAT2 HMGCS1 HMGCS1 FDFT1 FDFT1 ERG28 ERG28 APOBR APOBR ENSRROP00000041406 ENSRROP00000041406 SCARF1 SCARF1 MBTPS2 MBTPS2 APOA1 APOA1 NFE2L1 NFE2L1 EBP EBP EBPL EBPL ACLY ACLY OSBPL1A OSBPL1A ABCG1 ABCG1 LOC104679775 LOC104679775
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
gene neighborhood
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Your Input:
STARSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (285 aa)
LOC104660718Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (347 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
ENSRROP00000001042START domain-containing protein. (252 aa)
ERLIN2ER lipid raft associated 2. (359 aa)
ABCA5ATP binding cassette subfamily A member 5. (1543 aa)
PLPP6Phospholipid phosphatase 6. (296 aa)
LOC104670080Uncharacterized protein; Belongs to the cytochrome P450 family. (508 aa)
ANGPTL3Angiopoietin like 3. (460 aa)
INSIG2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (225 aa)
HSD17B7Hydroxysteroid 17-beta dehydrogenase 7. (366 aa)
IDI2Isopentenyl-diphosphate delta isomerase 2. (154 aa)
HNF1AHNF1 homeobox A. (662 aa)
CH25HCholesterol 25-hydroxylase; Belongs to the sterol desaturase family. (272 aa)
MT3Metallothionein 3; Belongs to the metallothionein superfamily. Type 1 family. (113 aa)
CYP46A1Cytochrome P450 family 46 subfamily A member 1; Belongs to the cytochrome P450 family. (500 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1481 aa)
CYP8B1Cytochrome P450 family 8 subfamily B member 1; Belongs to the cytochrome P450 family. (496 aa)
CYP19A1Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. (503 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (543 aa)
LDLRLow density lipoprotein receptor. (855 aa)
CYP51A1Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family. (512 aa)
APOA2Truncated apolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism. (132 aa)
CYP26C1Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. (522 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
APOEApolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (317 aa)
SULT1C3Sulfotransferase; Belongs to the sulfotransferase 1 family. (304 aa)
SCAPSREBF chaperone. (1279 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (568 aa)
PON1Paraoxonase 1. (355 aa)
NSDHLNAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family. (374 aa)
CYP3A4Cytochrome P450 family 3 subfamily A member 4. (503 aa)
LOC104671485Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (457 aa)
ARV1ARV1 homolog, fatty acid homeostasis modulator. (271 aa)
PIP4P1Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (284 aa)
LIPELipase E, hormone sensitive type. (1054 aa)
LIMA1LIM domain and actin binding 1. (759 aa)
LOC104674109Uncharacterized protein; Belongs to the cytochrome P450 family. (401 aa)
CYB5R2NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (305 aa)
TSKUTsukushi, small leucine rich proteoglycan. (489 aa)
CYP1A2Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. (416 aa)
SQLESqualene epoxidase. (574 aa)
SREBF2Sterol regulatory element binding transcription factor 2. (1184 aa)
CYP7A1Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (504 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (283 aa)
ENSRROP00000017642Glucosylceramidase. (376 aa)
LOC104670158Uncharacterized protein; Belongs to the cytochrome P450 family. (512 aa)
CLN6CLN6 transmembrane ER protein. (336 aa)
ENSRROP00000017967Uncharacterized protein. (76 aa)
VLDLRVery low density lipoprotein receptor. (873 aa)
G6PDGlucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (545 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
CLN8CLN8 transmembrane ER and ERGIC protein. (286 aa)
GBA2Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. (928 aa)
LEPRLeptin receptor. (1163 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (509 aa)
SULT2A1Sulfotransferase; Belongs to the sulfotransferase 1 family. (285 aa)
HDLBPHigh density lipoprotein binding protein. (1295 aa)
HMGCS23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa)
CYB5R3NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (334 aa)
APOBApolipoprotein B. (4555 aa)
MVDDiphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. (401 aa)
LIPCLipase C, hepatic type. (499 aa)
CUBNCubilin. (3553 aa)
NPC1NPC intracellular cholesterol transporter 1. (1277 aa)
CYP39A1Cytochrome P450 family 39 subfamily A member 1; Belongs to the cytochrome P450 family. (469 aa)
SOAT1O-acyltransferase. (550 aa)
CYB5R1NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (305 aa)
ENSRROP00000023708Nudix hydrolase domain-containing protein. (154 aa)
LOC104671477Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (566 aa)
SC5DSterol-C5-desaturase; Belongs to the sterol desaturase family. (299 aa)
FDX1Ferredoxin 1. (210 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1611 aa)
PMVKPhosphomevalonate kinase. (192 aa)
CYP11A1Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (521 aa)
CYP27A1Cytochrome P450 family 27 subfamily A member 1; Belongs to the cytochrome P450 family. (531 aa)
CYP11B1Cytochrome P450 family 11 subfamily B member 1; Belongs to the cytochrome P450 family. (573 aa)
NPC2NPC intracellular cholesterol transporter 2. (229 aa)
CDCP2CUB domain containing protein 2. (540 aa)
ENSRROP00000028937Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (325 aa)
PRKAA1Non-specific serine/threonine protein kinase. (697 aa)
TM7SF2Transmembrane 7 superfamily member 2. (418 aa)
ABCA1ATP binding cassette subfamily A member 1. (2261 aa)
LOC104665604Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (514 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1177 aa)
LOC104660506Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (385 aa)
APOFApolipoprotein F. (326 aa)
FDPSFarnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. (419 aa)
GBAGlucosylceramidase. (533 aa)
PMP22Peripheral myelin protein 22; Might be involved in growth regulation, and in myelinization in the peripheral nervous system; Belongs to the PMP-22/EMP/MP20 family. (160 aa)
CYP7B1Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (505 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (888 aa)
CETPCholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. (493 aa)
APPAmyloid beta precursor protein. (770 aa)
PRKAA2Non-specific serine/threonine protein kinase. (560 aa)
LSSTerpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family. (732 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (644 aa)
PCSK9Proprotein convertase subtilisin/kexin type 9. (692 aa)
LCATLecithin-cholesterol acyltransferase. (440 aa)
LBRLamin B receptor. (615 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
NPC1L1NPC1 like intracellular cholesterol transporter 1. (1332 aa)
LDLRAP1Low density lipoprotein receptor adaptor protein 1. (302 aa)
DISP3Dispatched RND transporter family member 3. (1391 aa)
APOA5Apolipoprotein A5. (366 aa)
MBTPS1Membrane bound transcription factor peptidase, site 1. (1052 aa)
SULT2B1Sulfotransferase; Belongs to the sulfotransferase 1 family. (364 aa)
MVKMevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (418 aa)
TMEM130Transmembrane protein 130. (423 aa)
DHCR2424-dehydrocholesterol reductase. (590 aa)
CYP4V2Cytochrome P450 family 4 subfamily V member 2; Belongs to the cytochrome P450 family. (525 aa)
IDI1Isopentenyl-diphosphate delta isomerase 1. (280 aa)
DHCR77-dehydrocholesterol reductase. (475 aa)
FDXRNADPH:adrenodoxin oxidoreductase, mitochondrial. (528 aa)
OSBPL5Oxysterol-binding protein; Belongs to the OSBP family. (888 aa)
CYP26A1Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. (497 aa)
MSMO1Methylsterol monooxygenase 1; Belongs to the sterol desaturase family. (293 aa)
ERLIN1ER lipid raft associated 1. (348 aa)
NR0B2Nuclear receptor subfamily 0 group B member 2. (257 aa)
AKR1D1Aldo-keto reductase family 1 member D1. (326 aa)
SOAT2O-acyltransferase. (526 aa)
HMGCS13-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (520 aa)
FDFT1Farnesyl-diphosphate farnesyltransferase 1. (417 aa)
ERG28Ergosterol biosynthesis 28 homolog. (140 aa)
APOBRApolipoprotein B receptor. (1063 aa)
ENSRROP00000041406Uncharacterized protein. (115 aa)
SCARF1Scavenger receptor class F member 1. (809 aa)
MBTPS2Membrane bound transcription factor peptidase, site 2. (295 aa)
APOA1Apolipoprotein A1. (267 aa)
NFE2L1Nuclear factor, erythroid 2 like 1. (772 aa)
EBPEXPERA domain-containing protein. (230 aa)
EBPLEBP like. (206 aa)
ACLYATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. (1148 aa)
OSBPL1AOxysterol-binding protein; Belongs to the OSBP family. (950 aa)
ABCG1ATP binding cassette subfamily G member 1. (677 aa)
LOC104679775Uncharacterized protein; Belongs to the cytochrome P450 family. (503 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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