Your Input: | |
| | STAR | Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (285 aa) |
| | LOC104660718 | Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (347 aa) |
| | CAT | Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa) |
| | ENSRROP00000001042 | START domain-containing protein. (252 aa) |
| | ERLIN2 | ER lipid raft associated 2. (359 aa) |
| | ABCA5 | ATP binding cassette subfamily A member 5. (1543 aa) |
| | PLPP6 | Phospholipid phosphatase 6. (296 aa) |
| | LOC104670080 | Uncharacterized protein; Belongs to the cytochrome P450 family. (508 aa) |
| | ANGPTL3 | Angiopoietin like 3. (460 aa) |
| | INSIG2 | Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (225 aa) |
| | HSD17B7 | Hydroxysteroid 17-beta dehydrogenase 7. (366 aa) |
| | IDI2 | Isopentenyl-diphosphate delta isomerase 2. (154 aa) |
| | HNF1A | HNF1 homeobox A. (662 aa) |
| | CH25H | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. (272 aa) |
| | MT3 | Metallothionein 3; Belongs to the metallothionein superfamily. Type 1 family. (113 aa) |
| | CYP46A1 | Cytochrome P450 family 46 subfamily A member 1; Belongs to the cytochrome P450 family. (500 aa) |
| | CFTR | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1481 aa) |
| | CYP8B1 | Cytochrome P450 family 8 subfamily B member 1; Belongs to the cytochrome P450 family. (496 aa) |
| | CYP19A1 | Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. (503 aa) |
| | CYP1B1 | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (543 aa) |
| | LDLR | Low density lipoprotein receptor. (855 aa) |
| | CYP51A1 | Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family. (512 aa) |
| | APOA2 | Truncated apolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism. (132 aa) |
| | CYP26C1 | Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. (522 aa) |
| | PPARD | Peroxisome proliferator activated receptor delta. (441 aa) |
| | APOE | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (317 aa) |
| | SULT1C3 | Sulfotransferase; Belongs to the sulfotransferase 1 family. (304 aa) |
| | SCAP | SREBF chaperone. (1279 aa) |
| | PRKAG2 | Protein kinase AMP-activated non-catalytic subunit gamma 2. (568 aa) |
| | PON1 | Paraoxonase 1. (355 aa) |
| | NSDHL | NAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family. (374 aa) |
| | CYP3A4 | Cytochrome P450 family 3 subfamily A member 4. (503 aa) |
| | LOC104671485 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (457 aa) |
| | ARV1 | ARV1 homolog, fatty acid homeostasis modulator. (271 aa) |
| | PIP4P1 | Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (284 aa) |
| | LIPE | Lipase E, hormone sensitive type. (1054 aa) |
| | LIMA1 | LIM domain and actin binding 1. (759 aa) |
| | LOC104674109 | Uncharacterized protein; Belongs to the cytochrome P450 family. (401 aa) |
| | CYB5R2 | NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (305 aa) |
| | TSKU | Tsukushi, small leucine rich proteoglycan. (489 aa) |
| | CYP1A2 | Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. (416 aa) |
| | SQLE | Squalene epoxidase. (574 aa) |
| | SREBF2 | Sterol regulatory element binding transcription factor 2. (1184 aa) |
| | CYP7A1 | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (504 aa) |
| | INSIG1 | Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (283 aa) |
| | ENSRROP00000017642 | Glucosylceramidase. (376 aa) |
| | LOC104670158 | Uncharacterized protein; Belongs to the cytochrome P450 family. (512 aa) |
| | CLN6 | CLN6 transmembrane ER protein. (336 aa) |
| | ENSRROP00000017967 | Uncharacterized protein. (76 aa) |
| | VLDLR | Very low density lipoprotein receptor. (873 aa) |
| | G6PD | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (545 aa) |
| | LEP | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa) |
| | CLN8 | CLN8 transmembrane ER and ERGIC protein. (286 aa) |
| | GBA2 | Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. (928 aa) |
| | LEPR | Leptin receptor. (1163 aa) |
| | SCARB1 | Scavenger receptor class B member 1; Belongs to the CD36 family. (509 aa) |
| | SULT2A1 | Sulfotransferase; Belongs to the sulfotransferase 1 family. (285 aa) |
| | HDLBP | High density lipoprotein binding protein. (1295 aa) |
| | HMGCS2 | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa) |
| | CYB5R3 | NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (334 aa) |
| | APOB | Apolipoprotein B. (4555 aa) |
| | MVD | Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. (401 aa) |
| | LIPC | Lipase C, hepatic type. (499 aa) |
| | CUBN | Cubilin. (3553 aa) |
| | NPC1 | NPC intracellular cholesterol transporter 1. (1277 aa) |
| | CYP39A1 | Cytochrome P450 family 39 subfamily A member 1; Belongs to the cytochrome P450 family. (469 aa) |
| | SOAT1 | O-acyltransferase. (550 aa) |
| | CYB5R1 | NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (305 aa) |
| | ENSRROP00000023708 | Nudix hydrolase domain-containing protein. (154 aa) |
| | LOC104671477 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (566 aa) |
| | SC5D | Sterol-C5-desaturase; Belongs to the sterol desaturase family. (299 aa) |
| | FDX1 | Ferredoxin 1. (210 aa) |
| | LRP5 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1611 aa) |
| | PMVK | Phosphomevalonate kinase. (192 aa) |
| | CYP11A1 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (521 aa) |
| | CYP27A1 | Cytochrome P450 family 27 subfamily A member 1; Belongs to the cytochrome P450 family. (531 aa) |
| | CYP11B1 | Cytochrome P450 family 11 subfamily B member 1; Belongs to the cytochrome P450 family. (573 aa) |
| | NPC2 | NPC intracellular cholesterol transporter 2. (229 aa) |
| | CDCP2 | CUB domain containing protein 2. (540 aa) |
| | ENSRROP00000028937 | Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (325 aa) |
| | PRKAA1 | Non-specific serine/threonine protein kinase. (697 aa) |
| | TM7SF2 | Transmembrane 7 superfamily member 2. (418 aa) |
| | ABCA1 | ATP binding cassette subfamily A member 1. (2261 aa) |
| | LOC104665604 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (514 aa) |
| | SREBF1 | Sterol regulatory element binding transcription factor 1. (1177 aa) |
| | LOC104660506 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (385 aa) |
| | APOF | Apolipoprotein F. (326 aa) |
| | FDPS | Farnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. (419 aa) |
| | GBA | Glucosylceramidase. (533 aa) |
| | PMP22 | Peripheral myelin protein 22; Might be involved in growth regulation, and in myelinization in the peripheral nervous system; Belongs to the PMP-22/EMP/MP20 family. (160 aa) |
| | CYP7B1 | Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (505 aa) |
| | HMGCR | 3-hydroxy-3-methylglutaryl coenzyme A reductase. (888 aa) |
| | CETP | Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. (493 aa) |
| | APP | Amyloid beta precursor protein. (770 aa) |
| | PRKAA2 | Non-specific serine/threonine protein kinase. (560 aa) |
| | LSS | Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family. (732 aa) |
| | SMPD1 | Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (644 aa) |
| | PCSK9 | Proprotein convertase subtilisin/kexin type 9. (692 aa) |
| | LCAT | Lecithin-cholesterol acyltransferase. (440 aa) |
| | LBR | Lamin B receptor. (615 aa) |
| | CYP26B1 | Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa) |
| | NPC1L1 | NPC1 like intracellular cholesterol transporter 1. (1332 aa) |
| | LDLRAP1 | Low density lipoprotein receptor adaptor protein 1. (302 aa) |
| | DISP3 | Dispatched RND transporter family member 3. (1391 aa) |
| | APOA5 | Apolipoprotein A5. (366 aa) |
| | MBTPS1 | Membrane bound transcription factor peptidase, site 1. (1052 aa) |
| | SULT2B1 | Sulfotransferase; Belongs to the sulfotransferase 1 family. (364 aa) |
| | MVK | Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (418 aa) |
| | TMEM130 | Transmembrane protein 130. (423 aa) |
| | DHCR24 | 24-dehydrocholesterol reductase. (590 aa) |
| | CYP4V2 | Cytochrome P450 family 4 subfamily V member 2; Belongs to the cytochrome P450 family. (525 aa) |
| | IDI1 | Isopentenyl-diphosphate delta isomerase 1. (280 aa) |
| | DHCR7 | 7-dehydrocholesterol reductase. (475 aa) |
| | FDXR | NADPH:adrenodoxin oxidoreductase, mitochondrial. (528 aa) |
| | OSBPL5 | Oxysterol-binding protein; Belongs to the OSBP family. (888 aa) |
| | CYP26A1 | Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. (497 aa) |
| | MSMO1 | Methylsterol monooxygenase 1; Belongs to the sterol desaturase family. (293 aa) |
| | ERLIN1 | ER lipid raft associated 1. (348 aa) |
| | NR0B2 | Nuclear receptor subfamily 0 group B member 2. (257 aa) |
| | AKR1D1 | Aldo-keto reductase family 1 member D1. (326 aa) |
| | SOAT2 | O-acyltransferase. (526 aa) |
| | HMGCS1 | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (520 aa) |
| | FDFT1 | Farnesyl-diphosphate farnesyltransferase 1. (417 aa) |
| | ERG28 | Ergosterol biosynthesis 28 homolog. (140 aa) |
| | APOBR | Apolipoprotein B receptor. (1063 aa) |
| | ENSRROP00000041406 | Uncharacterized protein. (115 aa) |
| | SCARF1 | Scavenger receptor class F member 1. (809 aa) |
| | MBTPS2 | Membrane bound transcription factor peptidase, site 2. (295 aa) |
| | APOA1 | Apolipoprotein A1. (267 aa) |
| | NFE2L1 | Nuclear factor, erythroid 2 like 1. (772 aa) |
| | EBP | EXPERA domain-containing protein. (230 aa) |
| | EBPL | EBP like. (206 aa) |
| | ACLY | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. (1148 aa) |
| | OSBPL1A | Oxysterol-binding protein; Belongs to the OSBP family. (950 aa) |
| | ABCG1 | ATP binding cassette subfamily G member 1. (677 aa) |
| | LOC104679775 | Uncharacterized protein; Belongs to the cytochrome P450 family. (503 aa) |
