STRINGSTRING
C9orf72 C9orf72 ATP6V1B2 ATP6V1B2 HDAC6 HDAC6 TMEM39B TMEM39B TSC2 TSC2 SEC22B SEC22B EXOC1 EXOC1 TBK1 TBK1 PIP4K2C PIP4K2C PHF23 PHF23 SNX7 SNX7 QSOX1 QSOX1 ENSRROP00000038862 ENSRROP00000038862 IL4 IL4 EPM2A EPM2A ATG5 ATG5 CALCOCO2 CALCOCO2 LZTS1 LZTS1 MTMR8 MTMR8 SMG1 SMG1 WDR24 WDR24 HMOX1 HMOX1 RHEB RHEB LRRK2 LRRK2 SPTLC2 SPTLC2 FEZ2 FEZ2 TIGAR TIGAR ULK1 ULK1 VPS35 VPS35 TSC1 TSC1 PRKAA2 PRKAA2 ENSRROP00000032926 ENSRROP00000032926 ATP6V1H ATP6V1H HTT HTT MAPK3 MAPK3 PIK3C3 PIK3C3 NUPR1 NUPR1 ENSRROP00000031449 ENSRROP00000031449 PINK1 PINK1 ATP6V1C2 ATP6V1C2 SMCR8 SMCR8 UVRAG UVRAG ATP6V0C ATP6V0C BAG3 BAG3 PIK3R4 PIK3R4 SCOC SCOC LOC104658716 LOC104658716 POLDIP2 POLDIP2 MAPK10 MAPK10 FYCO1 FYCO1 SNX18 SNX18 PAFAH1B2 PAFAH1B2 USP36 USP36 TP53 TP53 KIAA1324 KIAA1324 ENSRROP00000026269 ENSRROP00000026269 MTOR MTOR KDR KDR ATP6V0B ATP6V0B CAPNS1 CAPNS1 SLC25A4 SLC25A4 TECPR1 TECPR1 NPC1 NPC1 PIP4K2B PIP4K2B SPTLC1 SPTLC1 ATP6V0A1 ATP6V0A1 FEZ1 FEZ1 BNIP3 BNIP3 NRBP2 NRBP2 AMBRA1 AMBRA1 SIRT1 SIRT1 TRIM13 TRIM13 LARP1 LARP1 RNF41 RNF41 PRAF2 PRAF2 ENSRROP00000019640 ENSRROP00000019640 SNX30 SNX30 CDK5 CDK5 CLN3 CLN3 ATG14 ATG14 RAB3GAP1 RAB3GAP1 DCN DCN SCFD1 SCFD1 SNX32 SNX32 ENSRROP00000017324 ENSRROP00000017324 RAB3GAP2 RAB3GAP2 ENSRROP00000016000 ENSRROP00000016000 BNIP3L BNIP3L VPS13C VPS13C SNX5 SNX5 GAPDH GAPDH LACRT LACRT PIK3CA PIK3CA CHMP4B CHMP4B GPSM1 GPSM1 TMEM39A TMEM39A EHMT2 EHMT2 EXOC7 EXOC7 ADRB2 ADRB2 WIPI1 WIPI1 ATG2A ATG2A SESN3 SESN3 VDAC1 VDAC1 MOAP1 MOAP1 WAC WAC CDK5R1 CDK5R1 LOC104664924 LOC104664924 HSPB8 HSPB8 TBC1D25 TBC1D25 EXOC8 EXOC8 HIF1A HIF1A ENSRROP00000000635 ENSRROP00000000635 ENSRROP00000000660 ENSRROP00000000660 UBQLN2 UBQLN2 ENSRROP00000001710 ENSRROP00000001710 VPS26A VPS26A RUBCN RUBCN AKT1 AKT1 IKBKG IKBKG ENSRROP00000002201 ENSRROP00000002201 NOD1 NOD1 SNX4 SNX4 NEDD4 NEDD4 ATP6V1E2 ATP6V1E2 RUFY4 RUFY4 ERN1 ERN1 MAPK8 MAPK8 ATP13A2 ATP13A2 SUPT5H SUPT5H EXOC4 EXOC4 NOD2 NOD2 ENSRROP00000045839 ENSRROP00000045839 VPS13D VPS13D RIPK2 RIPK2 LRSAM1 LRSAM1 PIP4K2A PIP4K2A LOC104666118 LOC104666118 USP30 USP30 SESN2 SESN2 STING1 STING1 ATP6V1G1 ATP6V1G1 RNF31 RNF31 LOC104677400 LOC104677400 CLEC16A CLEC16A ATP6V0A2 ATP6V0A2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
C9orf72C9orf72-SMCR8 complex subunit. (481 aa)
ATP6V1B2Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (538 aa)
HDAC6Histone deacetylase 6. (1258 aa)
TMEM39BTransmembrane protein 39B. (492 aa)
TSC2TSC complex subunit 2. (1807 aa)
SEC22BUncharacterized protein; Belongs to the synaptobrevin family. (215 aa)
EXOC1Exocyst complex component 1. (901 aa)
TBK1TANK binding kinase 1. (729 aa)
PIP4K2CPhosphatidylinositol-5-phosphate 4-kinase type 2 gamma. (421 aa)
PHF23PHD finger protein 23. (403 aa)
SNX7Sorting nexin 7. (451 aa)
QSOX1Sulfhydryl oxidase. (747 aa)
ENSRROP00000038862Protein kinase domain-containing protein. (265 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
EPM2AEPM2A glucan phosphatase, laforin. (193 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
CALCOCO2Calcium binding and coiled-coil domain 2. (470 aa)
LZTS1Leucine zipper tumor suppressor 1. (596 aa)
MTMR8Myotubularin related protein 8. (493 aa)
SMG1SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family. (2596 aa)
WDR24WD repeat domain 24. (905 aa)
HMOX1Heme oxygenase 1. (303 aa)
RHEBRas homolog, mTORC1 binding. (184 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
SPTLC2Serine palmitoyltransferase long chain base subunit 2. (560 aa)
FEZ2Uncharacterized protein. (182 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (270 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1013 aa)
VPS35Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (796 aa)
TSC1TSC complex subunit 1. (1163 aa)
PRKAA2Non-specific serine/threonine protein kinase. (560 aa)
ENSRROP00000032926Uncharacterized protein. (241 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa)
HTTHuntingtin. (3100 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (911 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (82 aa)
ENSRROP00000031449Uncharacterized protein. (208 aa)
PINK1PTEN induced kinase 1. (581 aa)
ATP6V1C2V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (437 aa)
SMCR8SMCR8-C9orf72 complex subunit. (936 aa)
UVRAGUV radiation resistance associated. (698 aa)
ATP6V0CV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa)
BAG3BCL2 associated athanogene 3. (524 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1358 aa)
SCOCShort coiled-coil protein. (158 aa)
LOC104658716Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (248 aa)
POLDIP2DNA polymerase delta interacting protein 2. (375 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
FYCO1FYVE and coiled-coil domain containing 1. (1498 aa)
SNX18Sorting nexin. (624 aa)
PAFAH1B2Platelet activating factor acetylhydrolase 1b catalytic subunit 2. (229 aa)
USP36Ubiquitin specific peptidase 36; Belongs to the peptidase C19 family. (1123 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
KIAA1324KIAA1324. (1011 aa)
ENSRROP00000026269V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (145 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
ATP6V0BATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family. (253 aa)
CAPNS1Calpain small subunit 1. (264 aa)
SLC25A4Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
TECPR1Tectonin beta-propeller repeat containing 1. (1165 aa)
NPC1NPC intracellular cholesterol transporter 1. (1277 aa)
PIP4K2BPhosphatidylinositol-5-phosphate 4-kinase type 2 beta. (416 aa)
SPTLC1Serine palmitoyltransferase long chain base subunit 1. (473 aa)
ATP6V0A1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (837 aa)
FEZ1Fasciculation and elongation protein zeta 1. (392 aa)
BNIP3BCL2 interacting protein 3. (194 aa)
NRBP2Nuclear receptor binding protein 2. (510 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1298 aa)
SIRT1Sirtuin 1. (746 aa)
TRIM13Tripartite motif containing 13. (410 aa)
LARP1La ribonucleoprotein domain family member 1. (1021 aa)
RNF41Ring finger protein 41. (317 aa)
PRAF2Uncharacterized protein. (361 aa)
ENSRROP00000019640Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (531 aa)
SNX30Sorting nexin family member 30. (437 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
CLN3Battenin. (438 aa)
ATG14Autophagy related 14. (492 aa)
RAB3GAP1RAB3 GTPase activating protein catalytic subunit 1. (989 aa)
DCNDecorin; May affect the rate of fibrils formation. (359 aa)
SCFD1Sec1 family domain containing 1; Belongs to the STXBP/unc-18/SEC1 family. (686 aa)
SNX32Sorting nexin; Involved in several stages of intracellular trafficking. (418 aa)
ENSRROP00000017324Uncharacterized protein. (258 aa)
RAB3GAP2RAB3 GTPase activating non-catalytic protein subunit 2. (1393 aa)
ENSRROP00000016000Uncharacterized protein. (203 aa)
BNIP3LBCL2 interacting protein 3 like. (218 aa)
VPS13CVacuolar protein sorting 13 homolog C. (3754 aa)
SNX5Sorting nexin; Involved in several stages of intracellular trafficking. (404 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (335 aa)
LACRTLacritin. (137 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CHMP4BCharged multivesicular body protein 4B. (224 aa)
GPSM1G protein signaling modulator 1. (707 aa)
TMEM39ATransmembrane protein 39A. (488 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1237 aa)
EXOC7Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (707 aa)
ADRB2Adrenoceptor beta 2. (415 aa)
WIPI1WD repeat domain, phosphoinositide interacting 1. (446 aa)
ATG2AAutophagy related 2A. (1936 aa)
SESN3Sestrin 3. (530 aa)
VDAC1Voltage dependent anion channel 1. (283 aa)
MOAP1Modulator of apoptosis 1. (351 aa)
WACWW domain containing adaptor with coiled-coil. (602 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (307 aa)
LOC104664924Ubiquitin-like domain-containing protein. (335 aa)
HSPB8Heat shock protein family B (small) member 8; Belongs to the small heat shock protein (HSP20) family. (196 aa)
TBC1D25TBC1 domain family member 25. (688 aa)
EXOC8Exocyst complex component 8. (725 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
ENSRROP00000000635Uncharacterized protein. (260 aa)
ENSRROP00000000660Uncharacterized protein; Belongs to the synaptobrevin family. (215 aa)
UBQLN2Ubiquilin 2. (624 aa)
ENSRROP00000001710V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
VPS26AVPS26, retromer complex component A. (327 aa)
RUBCNRubicon autophagy regulator. (996 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa)
ENSRROP00000002201V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
SNX4Sorting nexin 4. (450 aa)
NEDD4NEDD4 E3 ubiquitin protein ligase. (1083 aa)
ATP6V1E2ATPase H+ transporting V1 subunit E2. (226 aa)
RUFY4RUN and FYVE domain containing 4. (586 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (980 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ATP13A2Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1196 aa)
SUPT5HTranscription elongation factor SPT5. (1087 aa)
EXOC4Exocyst complex component 4. (974 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1040 aa)
ENSRROP00000045839Uncharacterized protein. (273 aa)
VPS13DVacuolar protein sorting 13 homolog D. (4376 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
LRSAM1Leucine rich repeat and sterile alpha motif containing 1. (723 aa)
PIP4K2APhosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (406 aa)
LOC104666118UBA domain-containing protein. (301 aa)
USP30Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (550 aa)
SESN2Sestrin 2. (518 aa)
STING1Transmembrane protein 173. (379 aa)
ATP6V1G1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
RNF31Uncharacterized protein. (1072 aa)
LOC104677400Uncharacterized protein. (173 aa)
CLEC16AC-type lectin domain containing 16A. (1053 aa)
ATP6V0A2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (856 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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