STRINGSTRING
SPINK5 SPINK5 CREB3L1 CREB3L1 THBS4 THBS4 ADAMTS1 ADAMTS1 FASLG FASLG ANGPT4 ANGPT4 HGS HGS TIE1 TIE1 APOH APOH STAT1 STAT1 YJEFN3 YJEFN3 TGFB2 TGFB2 AMOT AMOT CNMD CNMD ADGRB3 ADGRB3 KLF4 KLF4 ENSRROP00000031184 ENSRROP00000031184 HSPG2 HSPG2 ABCC8 ABCC8 CTNNB1 CTNNB1 THBS2 THBS2 EPN1 EPN1 COL4A2 COL4A2 ADGRB2 ADGRB2 ADAMTS9 ADAMTS9 SARS1 SARS1 PTPRM PTPRM KLF2 KLF2 TNMD TNMD SPRED1 SPRED1 SEMA3E SEMA3E FOXO4 FOXO4 SEMA4A SEMA4A ROCK2 ROCK2 NIBAN2 NIBAN2 GTF2I GTF2I VASH1 VASH1 CLDN5 CLDN5 CD160 CD160 DCN DCN NPR1 NPR1 SPARC SPARC HRG HRG SLC12A2 SLC12A2 NPPB NPPB GADD45A GADD45A ISM1 ISM1 SPRY2 SPRY2 STAB1 STAB1 FOXJ2 FOXJ2 PF4 PF4 NAXE NAXE MINAR1 MINAR1 SULF1 SULF1 PDE3B PDE3B PLK2 PLK2 RGCC RGCC EPHA2 EPHA2 E2F2 E2F2 EMILIN1 EMILIN1 TEK TEK ATF2 ATF2 ADGRB1 ADGRB1 SERPINE1 SERPINE1 ALOX5 ALOX5 HOXA5 HOXA5 LOC104657906 LOC104657906 KRIT1 KRIT1 GPR4 GPR4 PML PML GDF2 GDF2 EPN2 EPN2 SERPINF1 SERPINF1 CXCL10 CXCL10 GHRL GHRL IL17F IL17F SYNJ2BP SYNJ2BP ATP2B4 ATP2B4 COL4A3 COL4A3 TBC1D31 TBC1D31 DAB2IP DAB2IP SEMA6A SEMA6A PIK3CB PIK3CB MECP2 MECP2 THBS1 THBS1 AGO1 AGO1 ANGPT2 ANGPT2 NF1 NF1 ECSCR ECSCR ROCK1 ROCK1 HHEX HHEX
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SPINK5Serine peptidase inhibitor, Kazal type 5. (1087 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
THBS4Thrombospondin 4. (961 aa)
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif 1. (967 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (280 aa)
ANGPT4Angiopoietin 4. (503 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (796 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1138 aa)
APOHApolipoprotein H. (345 aa)
STAT1Signal transducer and activator of transcription. (787 aa)
YJEFN3YjeF N-terminal domain containing 3. (293 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
AMOTAngiomotin. (1086 aa)
CNMDChondromodulin. (334 aa)
ADGRB3Adhesion G protein-coupled receptor B3; Belongs to the G-protein coupled receptor 2 family. (1522 aa)
KLF4Kruppel like factor 4. (479 aa)
ENSRROP00000031184Fork-head domain-containing protein. (193 aa)
HSPG2Heparan sulfate proteoglycan 2. (4391 aa)
ABCC8ATP binding cassette subfamily C member 8. (1585 aa)
CTNNB1Catenin beta 1. (781 aa)
THBS2Thrombospondin 2. (1172 aa)
EPN1Epsin 1. (662 aa)
COL4A2Collagen type IV alpha 2 chain. (1712 aa)
ADGRB2Adhesion G protein-coupled receptor B2; Belongs to the G-protein coupled receptor 2 family. (1587 aa)
ADAMTS9ADAM metallopeptidase with thrombospondin type 1 motif 9. (1935 aa)
SARS1Seryl-tRNA synthetase. (536 aa)
PTPRMProtein tyrosine phosphatase receptor type M. (1407 aa)
KLF2Uncharacterized protein. (115 aa)
TNMDTenomodulin. (317 aa)
SPRED1Sprouty related EVH1 domain containing 1. (444 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (775 aa)
FOXO4Forkhead box O4. (505 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (778 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1383 aa)
NIBAN2Niban apoptosis regulator 2. (746 aa)
GTF2IGeneral transcription factor IIi. (998 aa)
VASH1Vasohibin 1. (365 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (279 aa)
CD160CD160 molecule. (232 aa)
DCNDecorin; May affect the rate of fibrils formation. (359 aa)
NPR1Guanylate cyclase. (1284 aa)
SPARCSecreted protein acidic and cysteine rich. (341 aa)
HRGHistidine rich glycoprotein. (526 aa)
SLC12A2Solute carrier family 12 member 2. (1210 aa)
NPPBNatriuretic peptide B. (134 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
ISM1Isthmin 1. (464 aa)
SPRY2Sprouty RTK signaling antagonist 2. (338 aa)
STAB1Stabilin 1. (2568 aa)
FOXJ2Forkhead box J2. (574 aa)
PF4C-X-C motif chemokine. (101 aa)
NAXENAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. (288 aa)
MINAR1Membrane integral NOTCH2 associated receptor 1. (916 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (869 aa)
PDE3BPhosphodiesterase. (1113 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
RGCCRegulator of cell cycle. (134 aa)
EPHA2EPH receptor A2. (1033 aa)
E2F2E2F transcription factor 2. (437 aa)
EMILIN1Elastin microfibril interfacer 1. (1016 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ADGRB1Adhesion G protein-coupled receptor B1; Belongs to the G-protein coupled receptor 2 family. (1508 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (444 aa)
ALOX5Arachidonate 5-lipoxygenase. (646 aa)
HOXA5Homeobox A5. (270 aa)
LOC104657906NAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. (288 aa)
KRIT1Uncharacterized protein. (736 aa)
GPR4G protein-coupled receptor 4; Belongs to the G-protein coupled receptor 1 family. (362 aa)
PMLPromyelocytic leukemia. (882 aa)
GDF2Growth differentiation factor 2. (429 aa)
EPN2Epsin 2. (641 aa)
SERPINF1Serpin family F member 1; Belongs to the serpin family. (418 aa)
CXCL10C-X-C motif chemokine. (98 aa)
GHRLGhrelin and obestatin prepropeptide. (136 aa)
IL17FInterleukin 17F. (163 aa)
SYNJ2BPSynaptojanin 2 binding protein. (145 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1205 aa)
COL4A3Collagen type IV alpha 3 chain. (1670 aa)
TBC1D31Uncharacterized protein. (1067 aa)
DAB2IPDAB2 interacting protein. (1189 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (1047 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (498 aa)
THBS1Thrombospondin 1. (1170 aa)
AGO1Argonaute RISC component 1; Belongs to the argonaute family. (857 aa)
ANGPT2Angiopoietin 2. (510 aa)
NF1Neurofibromin 1. (2821 aa)
ECSCRUncharacterized protein. (205 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
HHEXHematopoietically expressed homeobox. (266 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.