30 items (Rhinopithecus roxellana) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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co-expression

protein homology

Your Input:
	SFRP4	Secreted frizzled related protein 4. (368 aa)
	PTPRO	Protein tyrosine phosphatase receptor type O. (1216 aa)
	FRZB	Frizzled related protein. (325 aa)
	FZD4	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
	FZD8	Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (444 aa)
	SFRP2	Secreted frizzled related protein 2. (295 aa)
	FZD5	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
	ROR2	Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (942 aa)
	ENSRROP00000005643	Uncharacterized protein. (495 aa)
	APCDD1L	APC down-regulated 1 like. (501 aa)
	SFRP5	Secreted frizzled related protein 5. (319 aa)
	RECK	Reversion inducing cysteine rich protein with kazal motifs. (958 aa)
	CTHRC1	Collagen triple helix repeat containing 1. (243 aa)
	WIF1	WNT inhibitory factor 1. (379 aa)
	FZD6	Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
	PORCN	Porcupine O-acyltransferase; Belongs to the membrane-bound acyltransferase family. (461 aa)
	FZD9	Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (510 aa)
	FZD7	Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (575 aa)
	FZD2	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (571 aa)
	LRP5	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1611 aa)
	RYK	Receptor like tyrosine kinase. (623 aa)
	ROR1	Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (925 aa)
	FZD10	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (583 aa)
	SFRP1	Secreted frizzled related protein 1. (314 aa)
	APCDD1	APC down-regulated 1. (514 aa)
	FZD3	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
	LRP6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
	TRABD2B	TraB domain containing 2B. (517 aa)
	WLS	Wnt ligand secretion mediator. (543 aa)
	TRABD2A	TraB domain containing 2A. (505 aa)

Your Current Organism:

Rhinopithecus roxellana

NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APCDD1	LRP5	ENSRROP00000038041	ENSRROP00000025209	APC down-regulated 1.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.731
APCDD1L	LRP5	ENSRROP00000009650	ENSRROP00000025209	APC down-regulated 1 like.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.516
ENSRROP00000005643	LRP5	ENSRROP00000005643	ENSRROP00000025209	Uncharacterized protein.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.455
FRZB	LRP5	ENSRROP00000045005	ENSRROP00000025209	Frizzled related protein.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.507
FRZB	WIF1	ENSRROP00000045005	ENSRROP00000016792	Frizzled related protein.	WNT inhibitory factor 1.	0.575
FZD10	FZD3	ENSRROP00000034235	ENSRROP00000038568	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	0.410
FZD10	FZD6	ENSRROP00000034235	ENSRROP00000019458	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family.	0.450
FZD10	LRP5	ENSRROP00000034235	ENSRROP00000025209	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.946
FZD10	LRP6	ENSRROP00000034235	ENSRROP00000039283	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.943
FZD10	ROR1	ENSRROP00000034235	ENSRROP00000033135	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.	Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.	0.938
FZD10	ROR2	ENSRROP00000034235	ENSRROP00000004957	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.	Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.	0.939
FZD10	RYK	ENSRROP00000034235	ENSRROP00000027427	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.	Receptor like tyrosine kinase.	0.917
FZD10	SFRP1	ENSRROP00000034235	ENSRROP00000037110	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled related protein 1.	0.677
FZD10	SFRP2	ENSRROP00000034235	ENSRROP00000002446	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled related protein 2.	0.650
FZD10	SFRP4	ENSRROP00000034235	ENSRROP00000044543	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled related protein 4.	0.665
FZD10	SFRP5	ENSRROP00000034235	ENSRROP00000012289	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled related protein 5.	0.677
FZD2	FZD3	ENSRROP00000024536	ENSRROP00000038568	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	0.448
FZD2	FZD4	ENSRROP00000024536	ENSRROP00000002265	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family.	0.434
FZD2	FZD6	ENSRROP00000024536	ENSRROP00000019458	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family.	0.461
FZD2	LRP5	ENSRROP00000024536	ENSRROP00000025209	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.963