STRINGSTRING
LMBR1 LMBR1 HOXC11 HOXC11 WDPCP WDPCP FBN2 FBN2 SMAD4 SMAD4 GNA12 GNA12 WNT7A WNT7A CPLANE1 CPLANE1 NOTCH1 NOTCH1 IHH IHH HOXD12 HOXD12 ENSRROP00000039864 ENSRROP00000039864 ENSRROP00000039666 ENSRROP00000039666 HOXC10 HOXC10 RPGRIP1L RPGRIP1L MKS1 MKS1 LOC104663799 LOC104663799 BMP4 BMP4 CYP26B1 CYP26B1 ECE1 ECE1 TBX5 TBX5 HOXD13 HOXD13 ALX3 ALX3 MSX1 MSX1 LEF1 LEF1 RARB RARB WDR19 WDR19 TGFB2 TGFB2 OSR2 OSR2 LRP4 LRP4 TBC1D32 TBC1D32 FGF8 FGF8 CTNNB1 CTNNB1 MED1 MED1 FREM2 FREM2 TBX3 TBX3 ALDH1A2 ALDH1A2 FBXW4 FBXW4 LOC104677352 LOC104677352 WNT3 WNT3 CACNA1C CACNA1C BCL2L11 BCL2L11 NOTCH2 NOTCH2 FRAS1 FRAS1 RUNX2 RUNX2 PBX2 PBX2 DKK1 DKK1 ZBTB16 ZBTB16 FLVCR1 FLVCR1 SALL4 SALL4 C2CD3 C2CD3 LRP5 LRP5 ZNF358 ZNF358 HOXD10 HOXD10 BMPR1A BMPR1A SALL1 SALL1 HOXA10 HOXA10 PITX1 PITX1 GLI3 GLI3 RARG RARG PRRX1 PRRX1 DLX6 DLX6 SP8 SP8 FGF9 FGF9 MYH3 MYH3 AFF3 AFF3 TFAP2A TFAP2A FZD6 FZD6 ENSRROP00000019405 ENSRROP00000019405 ENSRROP00000019238 ENSRROP00000019238 HOXA13 HOXA13 SHOX2 SHOX2 PBX1 PBX1 HDAC2 HDAC2 DLX5 DLX5 HOXD9 HOXD9 SHH SHH WNT5A WNT5A INTU INTU HDAC1 HDAC1 CRABP2 CRABP2 HAND2 HAND2 SKI SKI ALX4 ALX4 RECK RECK TMEM107 TMEM107 HOXA11 HOXA11 MAP3K20 MAP3K20 TBX4 TBX4 MEGF8 MEGF8 DYNC2H1 DYNC2H1 OSR1 OSR1 TULP3 TULP3 IMPAD1 IMPAD1 FGF4 FGF4 NIPBL NIPBL BAX BAX EN1 EN1 RSPO2 RSPO2 PSEN1 PSEN1 HNF1A HNF1A IFT52 IFT52 NOG NOG GDF5 GDF5 IFT140 IFT140 TP63 TP63 TBX2 TBX2 SFRP2 SFRP2 CHD7 CHD7 BMP7 BMP7 RDH10 RDH10 GRHL2 GRHL2 ACD ACD ECE2 ECE2 MBNL1 MBNL1 CREBBP CREBBP PTCH1 PTCH1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LMBR1Limb development membrane protein 1; Belongs to the LIMR family. (529 aa)
HOXC11Homeobox C11. (304 aa)
WDPCPWD repeat containing planar cell polarity effector. (608 aa)
FBN2Fibrillin 2. (2912 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
GNA12G protein subunit alpha 12. (381 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
CPLANE1Ciliogenesis and planar polarity effector 1. (3201 aa)
NOTCH1Notch receptor 1. (2560 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
HOXD12Homeobox D12. (270 aa)
ENSRROP00000039864Homeobox domain-containing protein. (142 aa)
ENSRROP00000039666Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (483 aa)
HOXC10Homeobox C10. (342 aa)
RPGRIP1LRPGRIP1 like. (1314 aa)
MKS1MKS transition zone complex subunit 1. (559 aa)
LOC104663799Uncharacterized protein. (246 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
ECE1Endothelin converting enzyme 1. (858 aa)
TBX5T-box transcription factor 5. (518 aa)
HOXD13Homeobox D13. (300 aa)
ALX3ALX homeobox 3. (343 aa)
MSX1Msh homeobox 1. (261 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
RARBRetinoic acid receptor beta. (448 aa)
WDR19WD repeat domain 19. (1342 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
OSR2Odd-skipped related transciption factor 2. (423 aa)
LRP4LDL receptor related protein 4. (1903 aa)
TBC1D32TBC1 domain family member 32. (857 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
CTNNB1Catenin beta 1. (781 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1582 aa)
FREM2FRAS1 related extracellular matrix 2. (3170 aa)
TBX3T-box transcription factor 3. (743 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
FBXW4F-box and WD repeat domain containing 4. (411 aa)
LOC104677352Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (484 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
CACNA1CCa_chan_IQ domain-containing protein. (829 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
NOTCH2Notch receptor 2. (2471 aa)
FRAS1Fraser extracellular matrix complex subunit 1. (4011 aa)
RUNX2RUNX family transcription factor 2. (541 aa)
PBX2PBX homeobox 2. (430 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (266 aa)
ZBTB16Zinc finger and BTB domain containing 16. (673 aa)
FLVCR1Feline leukemia virus subgroup C cellular receptor 1. (555 aa)
SALL4Spalt like transcription factor 4. (1053 aa)
C2CD3C2 domain containing 3 centriole elongation regulator. (2353 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1611 aa)
ZNF358Zinc finger protein 358. (556 aa)
HOXD10Homeobox D10. (340 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
SALL1Spalt like transcription factor 1. (1304 aa)
HOXA10Homeobox A10. (410 aa)
PITX1Homeobox protein. (314 aa)
GLI3GLI family zinc finger 3. (1580 aa)
RARGRetinoic acid receptor gamma. (456 aa)
PRRX1Paired related homeobox 1. (245 aa)
DLX6Distal-less homeobox 6. (276 aa)
SP8Sp8 transcription factor. (507 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
MYH3Myosin heavy chain 3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1904 aa)
AFF3AF4/FMR2 family member 3. (1251 aa)
TFAP2ATranscription factor AP-2 alpha. (439 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
ENSRROP00000019405Hist_deacetyl domain-containing protein. (352 aa)
ENSRROP00000019238Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (785 aa)
HOXA13Homeobox A13. (219 aa)
SHOX2Short stature homeobox 2. (355 aa)
PBX1PBX homeobox 1. (430 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
DLX5Distal-less homeobox 5. (289 aa)
HOXD9Homeobox D9. (348 aa)
SHHHH_signal domain-containing protein. (141 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
INTUInturned planar cell polarity protein. (942 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (477 aa)
CRABP2Cellular retinoic acid binding protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (138 aa)
HAND2Heart and neural crest derivatives expressed 2. (287 aa)
SKISKI proto-oncogene. (770 aa)
ALX4ALX homeobox 4. (409 aa)
RECKReversion inducing cysteine rich protein with kazal motifs. (958 aa)
TMEM107Transmembrane protein 107. (140 aa)
HOXA11Homeobox A11. (313 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase 20. (800 aa)
TBX4T-box transcription factor 4. (584 aa)
MEGF8Multiple EGF like domains 8. (2834 aa)
DYNC2H1Dynein cytoplasmic 2 heavy chain 1. (4150 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
TULP3TUB like protein 3; Belongs to the TUB family. (482 aa)
IMPAD1Inositol monophosphatase domain containing 1. (373 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
NIPBLNipped-B protein. (2804 aa)
BAXBCL2 associated X, apoptosis regulator. (197 aa)
EN1Homeobox protein engrailed-like. (355 aa)
RSPO2R-spondin 2. (243 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (465 aa)
HNF1AHNF1 homeobox A. (662 aa)
IFT52Intraflagellar transport 52. (437 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
GDF5Growth differentiation factor 5. (499 aa)
IFT140Intraflagellar transport 140. (1466 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (659 aa)
TBX2T-box transcription factor 2. (712 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2998 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
GRHL2Grainyhead like transcription factor 2. (633 aa)
ACDACD shelterin complex subunit and telomerase recruitment factor. (527 aa)
ECE2EEF1AKMT4-ECE2 readthrough. (883 aa)
MBNL1Muscleblind like splicing regulator 1. (399 aa)
CREBBPCREB binding protein. (2442 aa)
PTCH1Patched 1. (1448 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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