STRINGSTRING
LOC104678360 LOC104678360 PTCH1 PTCH1 SERPINF1 SERPINF1 TP63 TP63 NOG NOG FGF10 FGF10 TNC TNC STK11 STK11 CYP19A1 CYP19A1 PRLR PRLR EAF2 EAF2 HOXA11 HOXA11 FEM1B FEM1B PTEN PTEN PLAG1 PLAG1 LOC104668178 LOC104668178 SHH SHH FGFR2 FGFR2 RARA RARA HOXA13 HOXA13 FKBP4 FKBP4 PSAP PSAP GLI1 GLI1 RARG RARG NKX3-1 NKX3-1 HOXA10 HOXA10 AR AR SOX9 SOX9 CDKN1B CDKN1B MMP2 MMP2 CTNNB1 CTNNB1 CYP7B1 CYP7B1 UBE3A UBE3A HOXD13 HOXD13 FRS2 FRS2 ID4 ID4 BMP4 BMP4 SFRP1 SFRP1 HOXB13 HOXB13 ENSRROP00000039864 ENSRROP00000039864 NOTCH1 NOTCH1 WDR77 WDR77 SERPINB5 SERPINB5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC104678360Nuclear receptor domain-containing protein. (231 aa)
PTCH1Patched 1. (1448 aa)
SERPINF1Serpin family F member 1; Belongs to the serpin family. (418 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (659 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
TNCTenascin C. (2201 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
CYP19A1Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. (503 aa)
PRLRProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (619 aa)
EAF2ELL associated factor 2. (263 aa)
HOXA11Homeobox A11. (313 aa)
FEM1BFem-1 homolog B. (627 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
PLAG1PLAG1 zinc finger. (500 aa)
LOC104668178Uncharacterized protein. (392 aa)
SHHHH_signal domain-containing protein. (141 aa)
FGFR2Fibroblast growth factor receptor. (837 aa)
RARARetinoic acid receptor alpha. (478 aa)
HOXA13Homeobox A13. (219 aa)
FKBP4Peptidylprolyl isomerase. (459 aa)
PSAPProsaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. (530 aa)
GLI1GLI family zinc finger 1. (1106 aa)
RARGRetinoic acid receptor gamma. (456 aa)
NKX3-1NK3 homeobox 1. (232 aa)
HOXA10Homeobox A10. (410 aa)
ARUncharacterized protein. (523 aa)
SOX9SRY-box transcription factor 9. (509 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
MMP2Matrix metallopeptidase 2. (660 aa)
CTNNB1Catenin beta 1. (781 aa)
CYP7B1Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (505 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (877 aa)
HOXD13Homeobox D13. (300 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
ID4Inhibitor of DNA binding 4, HLH protein. (153 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
HOXB13Homeobox B13. (284 aa)
ENSRROP00000039864Homeobox domain-containing protein. (142 aa)
NOTCH1Notch receptor 1. (2560 aa)
WDR77WD repeat domain 77. (342 aa)
SERPINB5Serpin family B member 5; Belongs to the serpin family. (375 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
Server load: low (20%) [HD]