(42 nodes) Negative regulation of epithelial cell differentiation network (Rhinopithecus roxellana)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EZH2	Enhancer of zeste 2 polycomb repressive complex 2 subunit. (737 aa)
	FST	Follistatin. (350 aa)
	FRZB	Frizzled related protein. (325 aa)
	SPRED3	Sprouty related EVH1 domain containing 3. (442 aa)
	NOTCH1	Notch receptor 1. (2560 aa)
	SIX2	SIX homeobox 2. (290 aa)
	ZEB1	Zinc finger E-box binding homeobox 1. (1127 aa)
	REG3A	Regenerating family member 3 alpha. (175 aa)
	STAT1	Signal transducer and activator of transcription. (787 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	OVOL2	Ovo like zinc finger 2. (275 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	TBX3	T-box transcription factor 3. (743 aa)
	NODAL	Nodal growth differentiation factor. (347 aa)
	ENSRROP00000027148	Cyclin N-terminal domain-containing protein. (74 aa)
	SPRED1	Sprouty related EVH1 domain containing 1. (444 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (147 aa)
	REG3G	Regenerating family member 3 gamma. (174 aa)
	ENSRROP00000022699	Uncharacterized protein. (356 aa)
	YAP1	Yes associated protein 1. (508 aa)
	ID1	Inhibitor of DNA binding 1, HLH protein. (154 aa)
	CCND1	Cyclin D1; Belongs to the cyclin family. (253 aa)
	ACVRL1	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
	MMP9	Matrix metallopeptidase 9. (703 aa)
	SPRY2	Sprouty RTK signaling antagonist 2. (338 aa)
	FOXJ2	Forkhead box J2. (574 aa)
	SPRED2	Sprouty related EVH1 domain containing 2. (432 aa)
	NOTCH4	Notch receptor 4. (2037 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	GDF3	Growth differentiation factor 3. (364 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (748 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
	SRSF6	Serine and arginine rich splicing factor 6. (343 aa)
	OSR1	Odd-skipped related transcription factor 1. (266 aa)
	ENSRROP00000009442	Uncharacterized protein. (179 aa)
	NKX6-3	Homeobox domain-containing protein. (263 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (659 aa)
	GRHL2	Grainyhead like transcription factor 2. (633 aa)
	XDH	Xanthine dehydrogenase. (1280 aa)
	S1PR3	Sphingosine-1-phosphate receptor 3; Belongs to the G-protein coupled receptor 1 family. (378 aa)
	SPRY1	Sprouty RTK signaling antagonist 1. (319 aa)

Your Current Organism:

Rhinopithecus roxellana

NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAV1	CTNNB1	ENSRROP00000024200	ENSRROP00000030288	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Catenin beta 1.	0.706
CAV1	SPRED1	ENSRROP00000024200	ENSRROP00000026904	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Sprouty related EVH1 domain containing 1.	0.471
CAV1	SPRED2	ENSRROP00000024200	ENSRROP00000015662	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Sprouty related EVH1 domain containing 2.	0.446
CCND1	CTNNB1	ENSRROP00000017233	ENSRROP00000030288	Cyclin D1; Belongs to the cyclin family.	Catenin beta 1.	0.545
CCND1	MMP9	ENSRROP00000017233	ENSRROP00000016862	Cyclin D1; Belongs to the cyclin family.	Matrix metallopeptidase 9.	0.416
CCND1	NOTCH1	ENSRROP00000017233	ENSRROP00000040966	Cyclin D1; Belongs to the cyclin family.	Notch receptor 1.	0.448
CTNNB1	CAV1	ENSRROP00000030288	ENSRROP00000024200	Catenin beta 1.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.706
CTNNB1	CCND1	ENSRROP00000030288	ENSRROP00000017233	Catenin beta 1.	Cyclin D1; Belongs to the cyclin family.	0.545
CTNNB1	DLL1	ENSRROP00000030288	ENSRROP00000012507	Catenin beta 1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.424
CTNNB1	ENSRROP00000009442	ENSRROP00000030288	ENSRROP00000009442	Catenin beta 1.	Uncharacterized protein.	0.463
CTNNB1	ENSRROP00000022699	ENSRROP00000030288	ENSRROP00000022699	Catenin beta 1.	Uncharacterized protein.	0.803
CTNNB1	ENSRROP00000027148	ENSRROP00000030288	ENSRROP00000027148	Catenin beta 1.	Cyclin N-terminal domain-containing protein.	0.545
CTNNB1	EZH2	ENSRROP00000030288	ENSRROP00000020305	Catenin beta 1.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.749
CTNNB1	FRZB	ENSRROP00000030288	ENSRROP00000045005	Catenin beta 1.	Frizzled related protein.	0.495
CTNNB1	JAG1	ENSRROP00000030288	ENSRROP00000013833	Catenin beta 1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.452
CTNNB1	KRAS	ENSRROP00000030288	ENSRROP00000032888	Catenin beta 1.	KRAS proto-oncogene, GTPase.	0.463
CTNNB1	MMP9	ENSRROP00000030288	ENSRROP00000016862	Catenin beta 1.	Matrix metallopeptidase 9.	0.508
CTNNB1	NOTCH1	ENSRROP00000030288	ENSRROP00000040966	Catenin beta 1.	Notch receptor 1.	0.682
CTNNB1	SMO	ENSRROP00000030288	ENSRROP00000011831	Catenin beta 1.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.473
CTNNB1	YAP1	ENSRROP00000030288	ENSRROP00000019863	Catenin beta 1.	Yes associated protein 1.	0.803