STRINGSTRING
PTCH1 PTCH1 HIF1A HIF1A FOXB1 FOXB1 XDH XDH GPAT4 GPAT4 ID2 ID2 TGFB3 TGFB3 STAT5A STAT5A AKT1 AKT1 CSF1R CSF1R ORAI1 ORAI1 TGFBR2 TGFBR2 DDR1 DDR1 TBX2 TBX2 WNT2 WNT2 PML PML FGF10 FGF10 NTN1 NTN1 AGAP2 AGAP2 ENSRROP00000005676 ENSRROP00000005676 FOXF1 FOXF1 MST1 MST1 CYP19A1 CYP19A1 HOXA5 HOXA5 TNFSF11 TNFSF11 PRLR PRLR SLC29A1 SLC29A1 CSN3 CSN3 ATP2C2 ATP2C2 EPHA2 EPHA2 JAK2 JAK2 ENSRROP00000011292 ENSRROP00000011292 USF2 USF2 SMO SMO BTRC BTRC HK2 HK2 SCRIB SCRIB SLC6A3 SLC6A3 BSX BSX NOTCH4 NOTCH4 APRT APRT LOC104668178 LOC104668178 WNT5A WNT5A ENSRROP00000015874 ENSRROP00000015874 HOXD9 HOXD9 ZBTB7B ZBTB7B ENSRROP00000016433 ENSRROP00000016433 KDM5B KDM5B CCND1 CCND1 IRS2 IRS2 PRL PRL FGFR2 FGFR2 STAT6 STAT6 ATP7B ATP7B IRF6 IRF6 TNFRSF11A TNFRSF11A SRC SRC IGFBP5 IGFBP5 ENSRROP00000021453 ENSRROP00000021453 SOSTDC1 SOSTDC1 CSF1 CSF1 ARG1 ARG1 GLI3 GLI3 ENSRROP00000022907 ENSRROP00000022907 CREB1 CREB1 NRG3 NRG3 EGF EGF ARHGAP35 ARHGAP35 SLC29A2 SLC29A2 LATS1 LATS1 CAV1 CAV1 WNT4 WNT4 MAPK1 MAPK1 LRP5 LRP5 AR AR ENSRROP00000026818 ENSRROP00000026818 ENSRROP00000027148 ENSRROP00000027148 ENSRROP00000027830 ENSRROP00000027830 WNT3A WNT3A PYGO2 PYGO2 BCL2L11 BCL2L11 VDR VDR NRG1 NRG1 PAM PAM WNT3 WNT3 TBX3 TBX3 MED1 MED1 ERBB4 ERBB4 CSMD2 CSMD2 ELF3 ELF3 CSN2 CSN2 LRRC1 LRRC1 CSMD1 CSMD1 LEF1 LEF1 ENSRROP00000033455 ENSRROP00000033455 MSX1 MSX1 TPH1 TPH1 TDGF1 TDGF1 ENSRROP00000036566 ENSRROP00000036566 BMP4 BMP4 ITGA2 ITGA2 TGFA TGFA RPLP0 RPLP0 NEURL1 NEURL1 NCOR2 NCOR2 TGFB1 TGFB1 ARHGAP5 ARHGAP5 FASN FASN ENSRROP00000040347 ENSRROP00000040347 AREG AREG AKT2 AKT2 ZNF703 ZNF703 WNT7B WNT7B HOXB9 HOXB9 APLN APLN IQGAP3 IQGAP3 ATP7A ATP7A SOCS2 SOCS2 LOC104678360 LOC104678360 KALRN KALRN NFKB1 NFKB1 GLI2 GLI2 STAT5B STAT5B GHRHR GHRHR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTCH1Patched 1. (1448 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
FOXB1Forkhead box B1. (325 aa)
XDHXanthine dehydrogenase. (1280 aa)
GPAT4Glycerol-3-phosphate acyltransferase 4. (456 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
STAT5ASignal transducer and activator of transcription. (905 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (975 aa)
ORAI1ORAI calcium release-activated calcium modulator 1. (300 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
DDR1Discoidin domain receptor tyrosine kinase 1. (996 aa)
TBX2T-box transcription factor 2. (712 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
PMLPromyelocytic leukemia. (882 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
NTN1Netrin 1. (604 aa)
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1196 aa)
ENSRROP00000005676Nucleoside diphosphate kinase. (152 aa)
FOXF1Forkhead box F1. (379 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. (752 aa)
CYP19A1Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. (503 aa)
HOXA5Homeobox A5. (270 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (317 aa)
PRLRProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (619 aa)
SLC29A1Solute carrier family 29 member 1 (Augustine blood group). (522 aa)
CSN3Kappa-casein; Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk; Belongs to the kappa-casein family. (182 aa)
ATP2C2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (975 aa)
EPHA2EPH receptor A2. (1033 aa)
JAK2Tyrosine-protein kinase. (1094 aa)
ENSRROP00000011292RL10P_insert domain-containing protein. (336 aa)
USF2Upstream transcription factor 2, c-fos interacting. (315 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
HK2Hexokinase 2. (917 aa)
SCRIBScribble planar cell polarity protein. (1660 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (620 aa)
BSXBrain specific homeobox. (232 aa)
NOTCH4Notch receptor 4. (2037 aa)
APRTAdenine phosphoribosyltransferase. (256 aa)
LOC104668178Uncharacterized protein. (392 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
ENSRROP00000015874EGF-like domain-containing protein. (153 aa)
HOXD9Homeobox D9. (348 aa)
ZBTB7BZinc finger and BTB domain containing 7B. (573 aa)
ENSRROP00000016433RL10P_insert domain-containing protein. (180 aa)
KDM5BLysine demethylase 5B. (1580 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (253 aa)
IRS2Insulin receptor substrate 2. (1006 aa)
PRLProlactin. (228 aa)
FGFR2Fibroblast growth factor receptor. (837 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
ATP7BATPase copper transporting beta. (1465 aa)
IRF6Interferon regulatory factor 6. (467 aa)
TNFRSF11ATNF receptor superfamily member 11a. (595 aa)
SRCTyrosine-protein kinase. (540 aa)
IGFBP5Insulin like growth factor binding protein 5. (272 aa)
ENSRROP00000021453Nucleoside diphosphate kinase. (172 aa)
SOSTDC1Sclerostin domain containing 1. (230 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (555 aa)
ARG1Arginase. (322 aa)
GLI3GLI family zinc finger 3. (1580 aa)
ENSRROP00000022907RL10P_insert domain-containing protein. (238 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
NRG3Neuregulin 3. (402 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1233 aa)
ARHGAP35Rho GTPase activating protein 35. (1499 aa)
SLC29A2Solute carrier family 29 member 2. (456 aa)
LATS1Large tumor suppressor kinase 1. (1130 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (147 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (345 aa)
MAPK1Mitogen-activated protein kinase. (330 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1611 aa)
ARUncharacterized protein. (523 aa)
ENSRROP00000026818Uncharacterized protein. (319 aa)
ENSRROP00000027148Cyclin N-terminal domain-containing protein. (74 aa)
ENSRROP0000002783060S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10. (294 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
PYGO2Pygopus family PHD finger 2. (405 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
VDRVitamin D receptor. (477 aa)
NRG1Neuregulin 1. (713 aa)
PAMPeptidylglycine alpha-amidating monooxygenase. (975 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
TBX3T-box transcription factor 3. (743 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1582 aa)
ERBB4Receptor protein-tyrosine kinase. (1280 aa)
CSMD2CUB and Sushi multiple domains 2. (3484 aa)
ELF3E74 like ETS transcription factor 3. (414 aa)
CSN2Beta-casein; Important role in determination of the surface properties of the casein micelles. (226 aa)
LRRC1Leucine rich repeat containing 1. (524 aa)
CSMD1CUB and Sushi multiple domains 1. (3281 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
ENSRROP00000033455RL10P_insert domain-containing protein. (168 aa)
MSX1Msh homeobox 1. (261 aa)
TPH1Tryptophan hydroxylase 1. (444 aa)
TDGF1Growth factor; Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family. (187 aa)
ENSRROP00000036566Uncharacterized protein. (1309 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1151 aa)
TGFATransforming growth factor alpha. (166 aa)
RPLP060S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10. (318 aa)
NEURL1Neuralized E3 ubiquitin protein ligase 1. (574 aa)
NCOR2Nuclear receptor corepressor 2. (2522 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
ARHGAP5Rho GTPase activating protein 5. (1502 aa)
FASNFatty acid synthase. (2504 aa)
ENSRROP0000004034760S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10. (316 aa)
AREGAmphiregulin. (274 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ZNF703Zinc finger protein 703. (585 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (348 aa)
HOXB9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (250 aa)
APLNApelin. (77 aa)
IQGAP3IQ motif containing GTPase activating protein 3. (1632 aa)
ATP7AUncharacterized protein. (475 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
LOC104678360Nuclear receptor domain-containing protein. (231 aa)
KALRNKalirin RhoGEF kinase. (2980 aa)
NFKB1Nuclear factor kappa B subunit 1. (975 aa)
GLI2GLI family zinc finger 2. (1586 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
GHRHRGrowth hormone releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (423 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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