STRINGSTRING
GSK3B GSK3B PTCH1 PTCH1 ASXL1 ASXL1 AQP1 AQP1 IGFBP2 IGFBP2 GATA6 GATA6 PTK6 PTK6 ADNP2 ADNP2 FZD4 FZD4 SERPINF1 SERPINF1 TBX2 TBX2 WNT6 WNT6 TMEM161A TMEM161A LYN LYN BRINP3 BRINP3 CTSH CTSH AQP3 AQP3 GDAP1 GDAP1 OSR1 OSR1 TBXT TBXT ACER2 ACER2 WNT8A WNT8A ATP1A3 ATP1A3 WNT11 WNT11 OXT OXT DNAAF2 DNAAF2 WNT9A WNT9A TESC TESC HAND2 HAND2 SP100 SP100 WNT5A WNT5A PDGFA PDGFA BMP6 BMP6 LRAT LRAT TWF2 TWF2 FGFR2 FGFR2 LTK LTK RBP4 RBP4 HDAC2 HDAC2 WNT9B WNT9B RARA RARA YES1 YES1 ENSRROP00000019304 ENSRROP00000019304 YAP1 YAP1 IGFBP7 IGFBP7 CDKN2D CDKN2D BRINP1 BRINP1 ASCL1 ASCL1 STRA8 STRA8 WNT8B WNT8B RARG RARG ENSRROP00000022699 ENSRROP00000022699 CREB1 CREB1 FZD7 FZD7 PAX2 PAX2 IGF2R IGF2R DKK1 DKK1 BHMG1 BHMG1 WNT3A WNT3A TRIM16 TRIM16 PHC1 PHC1 RORB RORB WNT3 WNT3 ALDH1A2 ALDH1A2 MMP2 MMP2 ABCA1 ABCA1 SREBF1 SREBF1 KLF4 KLF4 SYNJ1 SYNJ1 ATM ATM TEAD2 TEAD2 ZNF35 ZNF35 HSD17B2 HSD17B2 SETX SETX FZD10 FZD10 RET RET CYP26B1 CYP26B1 ENSRROP00000034614 ENSRROP00000034614 TIE1 TIE1 RXRB RXRB PDGFRB PDGFRB HTRA2 HTRA2 ENSRROP00000037464 ENSRROP00000037464 CYP26A1 CYP26A1 EPHA3 EPHA3 PTK2B PTK2B PTK7 PTK7 RXRA RXRA MUC5AC MUC5AC HOXA2 HOXA2 BRINP2 BRINP2 GDAP2 GDAP2 COL1A1 COL1A1 WNT7B WNT7B WNT10B WNT10B ABL2 ABL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (309 aa)
PTCH1Patched 1. (1448 aa)
ASXL1ASXL transcriptional regulator 1. (1536 aa)
AQP1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa)
IGFBP2Insulin like growth factor binding protein 2. (325 aa)
GATA6GATA binding protein 6. (548 aa)
PTK6Tyrosine-protein kinase. (451 aa)
ADNP2ADNP homeobox 2. (1140 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
SERPINF1Serpin family F member 1; Belongs to the serpin family. (418 aa)
TBX2T-box transcription factor 2. (712 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa)
TMEM161ATransmembrane protein 161A. (479 aa)
LYNTyrosine-protein kinase. (491 aa)
BRINP3BMP/retinoic acid inducible neural specific 3. (766 aa)
CTSHCathepsin H; Belongs to the peptidase C1 family. (335 aa)
AQP3Aquaporin 3 (Gill blood group); Belongs to the MIP/aquaporin (TC 1.A.8) family. (292 aa)
GDAP1Ganglioside induced differentiation associated protein 1; Belongs to the GST superfamily. (358 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
TBXTT-box transcription factor T. (435 aa)
ACER2Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
ATP1A3Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1248 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
OXTOxytocin/neurophysin I prepropeptide; Belongs to the vasopressin/oxytocin family. (125 aa)
DNAAF2Protein kintoun; Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment. (838 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
TESCTescalcin. (214 aa)
HAND2Heart and neural crest derivatives expressed 2. (287 aa)
SP100SP100 nuclear antigen. (797 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (169 aa)
BMP6Bone morphogenetic protein 6. (439 aa)
LRATLRAT domain-containing protein. (230 aa)
TWF2Twinfilin actin binding protein 2. (349 aa)
FGFR2Fibroblast growth factor receptor. (837 aa)
LTKTyrosine-protein kinase receptor. (864 aa)
RBP4Retinol-binding protein; Retinol-binding protein that mediates retinol transport in blood plasma. (215 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
RARARetinoic acid receptor alpha. (478 aa)
YES1Tyrosine-protein kinase. (543 aa)
ENSRROP00000019304LRAT domain-containing protein. (214 aa)
YAP1Yes associated protein 1. (508 aa)
IGFBP7Insulin like growth factor binding protein 7. (282 aa)
CDKN2DCyclin dependent kinase inhibitor 2D. (166 aa)
BRINP1BMP/retinoic acid inducible neural specific 1. (761 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (234 aa)
STRA8Stimulated by retinoic acid 8. (330 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
RARGRetinoic acid receptor gamma. (456 aa)
ENSRROP00000022699Uncharacterized protein. (356 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (575 aa)
PAX2Paired box 2. (417 aa)
IGF2RInsulin like growth factor 2 receptor. (2486 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (266 aa)
BHMG1Basic helix-loop-helix and HMG-box containing 1. (642 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
TRIM16Uncharacterized protein. (557 aa)
PHC1Polyhomeotic homolog 1. (1005 aa)
RORBRAR related orphan receptor B. (475 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
MMP2Matrix metallopeptidase 2. (660 aa)
ABCA1ATP binding cassette subfamily A member 1. (2261 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1177 aa)
KLF4Kruppel like factor 4. (479 aa)
SYNJ1Synaptojanin 1. (1614 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
TEAD2TEA domain transcription factor 2. (451 aa)
ZNF35Zinc finger protein 35. (527 aa)
HSD17B2Hydroxysteroid 17-beta dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (387 aa)
SETXSenataxin. (2678 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (583 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1094 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
ENSRROP00000034614Tyrosine-protein kinase. (465 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1138 aa)
RXRBRetinoid X receptor beta. (542 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
HTRA2HtrA serine peptidase 2. (458 aa)
ENSRROP00000037464Uncharacterized protein. (301 aa)
CYP26A1Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. (497 aa)
EPHA3EPH receptor A3. (984 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1058 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1078 aa)
RXRARetinoid X receptor alpha. (481 aa)
MUC5ACUncharacterized protein. (3333 aa)
HOXA2Homeobox A2. (374 aa)
BRINP2BMP/retinoic acid inducible neural specific 2. (783 aa)
GDAP2Ganglioside induced differentiation associated protein 2. (497 aa)
COL1A1Collagen type I alpha 1 chain. (1464 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (348 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
ABL2Tyrosine-protein kinase. (1164 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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