STRINGSTRING
THBS1 THBS1 UBE2J1 UBE2J1 DHX9 DHX9 FOXP1 FOXP1 CLEC7A CLEC7A PLCG2 PLCG2 TIRAP TIRAP IL6 IL6 LOC104655302 LOC104655302 MIF MIF TLR3 TLR3 NOD1 NOD1 GPR18 GPR18 GHRL GHRL IRAK3 IRAK3 FZD5 FZD5 CD34 CD34 LILRA5 LILRA5 NFATC4 NFATC4 PSEN1 PSEN1 NOD2 NOD2 CD2 CD2 CD36 CD36 GSTP1 GSTP1 LBP LBP ENSRROP00000045771 ENSRROP00000045771 RIPK2 RIPK2 IL23A IL23A POMC POMC RASGRP1 RASGRP1 ARID5A ARID5A CD84 CD84 ENSRROP00000010437 ENSRROP00000010437 SASH3 SASH3 DDX58 DDX58 ISL1 ISL1 LTF LTF CLEC4A CLEC4A CCL19 CCL19 NFKBIL1 NFKBIL1 MYD88 MYD88 HAVCR2 HAVCR2 ADIPOQ ADIPOQ LOC104675310 LOC104675310 AKAP8 AKAP8 LILRB4 LILRB4 CYBB CYBB PTPN11 PTPN11 DICER1 DICER1 WNT5A WNT5A PF4 PF4 IL37 IL37 TREM2 TREM2 LOC104676775 LOC104676775 CACTIN CACTIN ARHGEF2 ARHGEF2 TLR4 TLR4 IFIH1 IFIH1 HDAC2 HDAC2 RARA RARA LEP LEP STAT3 STAT3 CHRNA7 CHRNA7 BTK BTK DDTL DDTL SYK SYK ACP5 ACP5 DDT DDT ARG2 ARG2 ENSRROP00000021422 ENSRROP00000021422 PIK3R1 PIK3R1 SPON2 SPON2 CD33 CD33 PTPRC PTPRC IFNGR1 IFNGR1 RIPK1 RIPK1 ERRFI1 ERRFI1 GHSR GHSR IL33 IL33 TRIM27 TRIM27 AGER AGER SPHK2 SPHK2 EPHB2 EPHB2 ENSRROP00000024628 ENSRROP00000024628 TMEM106A TMEM106A LY96 LY96 TICAM1 TICAM1 IL27RA IL27RA IGF1 IGF1 ZC3H12A ZC3H12A CARD9 CARD9 CIDEA CIDEA AXL AXL MMP8 MMP8 SIRPA SIRPA CD14 CD14 SLAMF1 SLAMF1 NLRC3 NLRC3 PTPN6 PTPN6 MAPKAPK2 MAPKAPK2 AKAP12 AKAP12 CX3CR1 CX3CR1 BPI BPI FOXP3 FOXP3 ABCC8 ABCC8 SELENOS SELENOS ILRUN ILRUN HSPB1 HSPB1 LOC104674799 LOC104674799 LILRA1 LILRA1 GAS6 GAS6 APP APP NR1H4 NR1H4 IL17A IL17A TSPO TSPO VSIR VSIR SYT11 SYT11 CLU CLU TNFRSF8 TNFRSF8 FADD FADD OAS2 OAS2 DEFB114 DEFB114 ENSRROP00000036200 ENSRROP00000036200 TNFAIP3 TNFAIP3 CYBA CYBA LRRK2 LRRK2 CX3CL1 CX3CL1 LPL LPL ZFP36 ZFP36 ORM1 ORM1 BCL3 BCL3 HLA-E HLA-E GPNMB GPNMB ARFGEF2 ARFGEF2 PYCARD PYCARD AZU1 AZU1 JAK2 JAK2 OAS3 OAS3 ZBTB20 ZBTB20 ENSRROP00000011759 ENSRROP00000011759 PTPN22 PTPN22 PTPRJ PTPRJ MAVS MAVS TUBB3 TUBB3 SETD4 SETD4 ANGPT1 ANGPT1 ENSRROP00000042123 ENSRROP00000042123 OAS1 OAS1 IL18 IL18 FRMD8 FRMD8 IL10 IL10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
THBS1Thrombospondin 1. (1170 aa)
UBE2J1Ubiquitin conjugating enzyme E2 J1. (318 aa)
DHX9DExH-box helicase 9. (1275 aa)
FOXP1Forkhead box P1. (694 aa)
CLEC7AC-type lectin domain containing 7A. (247 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
TIRAPTIR domain containing adaptor protein. (219 aa)
IL6Interleukin 6. (214 aa)
LOC104655302SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (205 aa)
MIFUncharacterized protein. (115 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
GPR18G protein-coupled receptor 18; Belongs to the G-protein coupled receptor 1 family. (331 aa)
GHRLGhrelin and obestatin prepropeptide. (136 aa)
IRAK3Interleukin 1 receptor associated kinase 3. (596 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
CD34CD34 molecule. (385 aa)
LILRA5Leukocyte immunoglobulin like receptor A5. (299 aa)
NFATC4Nuclear factor of activated T cells 4. (914 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (465 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1040 aa)
CD2CD2 molecule. (351 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
GSTP1Glutathione S-transferase pi 1; Belongs to the GST superfamily. (210 aa)
LBPLipopolysaccharide binding protein. (484 aa)
ENSRROP00000045771C1q domain-containing protein. (100 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
POMCProopiomelanocortin. (251 aa)
RASGRP1RAS guanyl releasing protein 1. (841 aa)
ARID5AAT-rich interaction domain 5A. (594 aa)
CD84CD84 molecule. (339 aa)
ENSRROP00000010437Uncharacterized protein. (235 aa)
SASH3SAM and SH3 domain containing 3. (380 aa)
DDX58DExD/H-box helicase 58. (925 aa)
ISL1ISL LIM homeobox 1. (349 aa)
LTFLactotransferrin; Belongs to the transferrin family. (732 aa)
CLEC4AC-type lectin domain family 4 member A. (239 aa)
CCL19C-C motif chemokine. (98 aa)
NFKBIL1NFKB inhibitor like 1. (381 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (293 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
LOC104675310Uncharacterized protein. (484 aa)
AKAP8A-kinase anchoring protein 8; Belongs to the AKAP95 family. (690 aa)
LILRB4Leukocyte immunoglobulin like receptor B4. (471 aa)
CYBBCytochrome b-245 beta chain. (570 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
DICER1Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1920 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
PF4C-X-C motif chemokine. (101 aa)
IL37Interleukin-1. (218 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
LOC104676775Ig-like domain-containing protein; Belongs to the MHC class I family. (391 aa)
CACTINCactin, spliceosome C complex subunit. (724 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1174 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
IFIH1Interferon induced with helicase C domain 1. (1025 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
RARARetinoic acid receptor alpha. (478 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
STAT3Signal transducer and activator of transcription. (802 aa)
CHRNA7Uncharacterized protein. (531 aa)
BTKTyrosine-protein kinase. (690 aa)
DDTLD-dopachrome tautomerase like. (121 aa)
SYKTyrosine-protein kinase. (635 aa)
ACP5Tartrate-resistant acid phosphatase type 5. (325 aa)
DDTUncharacterized protein. (159 aa)
ARG2Arginase. (354 aa)
ENSRROP00000021422Uncharacterized protein. (534 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
SPON2Spondin 2. (355 aa)
CD33CD33 molecule. (360 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1311 aa)
IFNGR1Interferon gamma receptor 1. (489 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
ERRFI1ERBB receptor feedback inhibitor 1. (462 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
IL33Interleukin 33. (270 aa)
TRIM27Tripartite motif containing 27. (513 aa)
AGERAdvanced glycosylation end-product specific receptor. (403 aa)
SPHK2Sphingosine kinase 2. (665 aa)
EPHB2EPH receptor B2. (1058 aa)
ENSRROP00000024628Ig-like domain-containing protein. (351 aa)
TMEM106ATransmembrane protein 106A. (262 aa)
LY96Lymphocyte antigen 96. (160 aa)
TICAM1Toll like receptor adaptor molecule 1. (522 aa)
IL27RAInterleukin 27 receptor subunit alpha. (636 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (208 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (601 aa)
CARD9Caspase recruitment domain family member 9. (536 aa)
CIDEACell death inducing DFFA like effector a. (219 aa)
AXLAXL receptor tyrosine kinase. (894 aa)
MMP8Matrix metallopeptidase 8. (467 aa)
SIRPAUncharacterized protein. (507 aa)
CD14CD14 molecule. (384 aa)
SLAMF1Signaling lymphocytic activation molecule family member 1. (357 aa)
NLRC3NLR family CARD domain containing 3. (1066 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
MAPKAPK2MAPK activated protein kinase 2. (322 aa)
AKAP12A-kinase anchoring protein 12. (1783 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (375 aa)
BPIBactericidal permeability increasing protein. (487 aa)
FOXP3Forkhead box P3. (454 aa)
ABCC8ATP binding cassette subfamily C member 8. (1585 aa)
SELENOSSelenoprotein S. (210 aa)
ILRUNInflammation and lipid regulator with UBA-like and NBR1-like domains. (298 aa)
HSPB1SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (205 aa)
LOC104674799Uncharacterized protein. (97 aa)
LILRA1Uncharacterized protein. (492 aa)
GAS6Growth arrest specific 6. (701 aa)
APPAmyloid beta precursor protein. (770 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (486 aa)
IL17AInterleukin 17A. (155 aa)
TSPOTranslocator protein. (169 aa)
VSIRV-set immunoregulatory receptor. (359 aa)
SYT11Synaptotagmin 11. (431 aa)
CLUClusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. (449 aa)
TNFRSF8TNF receptor superfamily member 8. (595 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
OAS22'-5'-oligoadenylate synthetase 2. (687 aa)
DEFB114Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (69 aa)
ENSRROP00000036200Uncharacterized protein. (491 aa)
TNFAIP3TNF alpha induced protein 3. (790 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (194 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (407 aa)
LPLLipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (475 aa)
ZFP36ZFP36 ring finger protein. (332 aa)
ORM1Orosomucoid 1. (213 aa)
BCL3BCL3 transcription coactivator. (454 aa)
HLA-EMajor histocompatibility complex, class I, E; Belongs to the MHC class I family. (364 aa)
GPNMBGlycoprotein nmb. (561 aa)
ARFGEF2ADP ribosylation factor guanine nucleotide exchange factor 2. (1785 aa)
PYCARDPYD and CARD domain containing. (195 aa)
AZU1Azurocidin 1. (250 aa)
JAK2Tyrosine-protein kinase. (1094 aa)
OAS32'-5'-oligoadenylate synthetase 3. (1092 aa)
ZBTB20Zinc finger and BTB domain containing 20. (741 aa)
ENSRROP00000011759Uncharacterized protein. (274 aa)
PTPN22Protein tyrosine phosphatase non-receptor type 22. (813 aa)
PTPRJProtein tyrosine phosphatase receptor type J. (1337 aa)
MAVSCARD_2 domain-containing protein. (545 aa)
TUBB3G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the tubulin family. (791 aa)
SETD4SET domain containing 4. (440 aa)
ANGPT1Angiopoietin 1. (498 aa)
ENSRROP00000042123Uncharacterized protein. (251 aa)
OAS12'-5'-oligoadenylate synthetase 1. (415 aa)
IL18Interleukin 18. (211 aa)
FRMD8FERM domain containing 8. (464 aa)
IL10Interleukin 10. (178 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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