95 items (Rhinopithecus roxellana) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	IL6	Interleukin 6. (214 aa)
	LOC104655302	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (205 aa)
	MIF	Uncharacterized protein. (115 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
	NOD1	Nucleotide binding oligomerization domain containing 1. (953 aa)
	FZD5	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
	LILRA5	Leukocyte immunoglobulin like receptor A5. (299 aa)
	NFATC4	Nuclear factor of activated T cells 4. (914 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (465 aa)
	NOD2	Nucleotide binding oligomerization domain containing 2. (1040 aa)
	CD2	CD2 molecule. (351 aa)
	CD36	CD36 molecule; Belongs to the CD36 family. (472 aa)
	LBP	Lipopolysaccharide binding protein. (484 aa)
	HAVCR2	Hepatitis A virus cellular receptor 2. (293 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
	CCL19	C-C motif chemokine. (98 aa)
	ISL1	ISL LIM homeobox 1. (349 aa)
	DDX58	DExD/H-box helicase 58. (925 aa)
	SASH3	SAM and SH3 domain containing 3. (380 aa)
	ENSRROP00000010437	Uncharacterized protein. (235 aa)
	CD84	CD84 molecule. (339 aa)
	ARID5A	AT-rich interaction domain 5A. (594 aa)
	JAK2	Tyrosine-protein kinase. (1094 aa)
	OAS3	2'-5'-oligoadenylate synthetase 3. (1092 aa)
	ZBTB20	Zinc finger and BTB domain containing 20. (741 aa)
	ENSRROP00000011759	Uncharacterized protein. (274 aa)
	PTPRJ	Protein tyrosine phosphatase receptor type J. (1337 aa)
	MAVS	CARD_2 domain-containing protein. (545 aa)
	IFIH1	Interferon induced with helicase C domain 1. (1025 aa)
	LOC104675310	Uncharacterized protein. (484 aa)
	CYBB	Cytochrome b-245 beta chain. (570 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	PF4	C-X-C motif chemokine. (101 aa)
	LOC104676775	Ig-like domain-containing protein; Belongs to the MHC class I family. (391 aa)
	ARHGEF2	Rho/Rac guanine nucleotide exchange factor 2. (1174 aa)
	TLR4	Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
	HDAC2	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
	STAT3	Signal transducer and activator of transcription. (802 aa)
	BTK	Tyrosine-protein kinase. (690 aa)
	DDTL	D-dopachrome tautomerase like. (121 aa)
	SYK	Tyrosine-protein kinase. (635 aa)
	DDT	Uncharacterized protein. (159 aa)
	ENSRROP00000021422	Uncharacterized protein. (534 aa)
	SPON2	Spondin 2. (355 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (1311 aa)
	IFNGR1	Interferon gamma receptor 1. (489 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (671 aa)
	IL33	Interleukin 33. (270 aa)
	AGER	Advanced glycosylation end-product specific receptor. (403 aa)
	SPHK2	Sphingosine kinase 2. (665 aa)
	EPHB2	EPH receptor B2. (1058 aa)
	TMEM106A	Transmembrane protein 106A. (262 aa)
	LY96	Lymphocyte antigen 96. (160 aa)
	TICAM1	Toll like receptor adaptor molecule 1. (522 aa)
	CARD9	Caspase recruitment domain family member 9. (536 aa)
	MMP8	Matrix metallopeptidase 8. (467 aa)
	CD14	CD14 molecule. (384 aa)
	MAPKAPK2	MAPK activated protein kinase 2. (322 aa)
	AKAP12	A-kinase anchoring protein 12. (1783 aa)
	ABCC8	ATP binding cassette subfamily C member 8. (1585 aa)
	HSPB1	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (205 aa)
	LOC104674799	Uncharacterized protein. (97 aa)
	LILRA1	Uncharacterized protein. (492 aa)
	APP	Amyloid beta precursor protein. (770 aa)
	IL17A	Interleukin 17A. (155 aa)
	CLU	Clusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. (449 aa)
	TNFRSF8	TNF receptor superfamily member 8. (595 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
	OAS2	2'-5'-oligoadenylate synthetase 2. (687 aa)
	ENSRROP00000036200	Uncharacterized protein. (491 aa)
	CYBA	Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (194 aa)
	LRRK2	Leucine rich repeat kinase 2. (2527 aa)
	LPL	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (475 aa)
	ORM1	Orosomucoid 1. (213 aa)
	HLA-E	Major histocompatibility complex, class I, E; Belongs to the MHC class I family. (364 aa)
	ARFGEF2	ADP ribosylation factor guanine nucleotide exchange factor 2. (1785 aa)
	PYCARD	PYD and CARD domain containing. (195 aa)
	AZU1	Azurocidin 1. (250 aa)
	SETD4	SET domain containing 4. (440 aa)
	ENSRROP00000042123	Uncharacterized protein. (251 aa)
	OAS1	2'-5'-oligoadenylate synthetase 1. (415 aa)
	IL18	Interleukin 18. (211 aa)
	FRMD8	FERM domain containing 8. (464 aa)
	THBS1	Thrombospondin 1. (1170 aa)
	DHX9	DExH-box helicase 9. (1275 aa)
	CLEC7A	C-type lectin domain containing 7A. (247 aa)
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
	TIRAP	TIR domain containing adaptor protein. (219 aa)
	RASGRP1	RAS guanyl releasing protein 1. (841 aa)
	IL23A	Interleukin 23 subunit alpha. (189 aa)
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
	ENSRROP00000045771	C1q domain-containing protein. (100 aa)

Your Current Organism:

Rhinopithecus roxellana

NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGER	APP	ENSRROP00000023644	ENSRROP00000033171	Advanced glycosylation end-product specific receptor.	Amyloid beta precursor protein.	0.644
AGER	CD36	ENSRROP00000023644	ENSRROP00000005762	Advanced glycosylation end-product specific receptor.	CD36 molecule; Belongs to the CD36 family.	0.420
AGER	CYBB	ENSRROP00000023644	ENSRROP00000014891	Advanced glycosylation end-product specific receptor.	Cytochrome b-245 beta chain.	0.912
AGER	JAK2	ENSRROP00000023644	ENSRROP00000011033	Advanced glycosylation end-product specific receptor.	Tyrosine-protein kinase.	0.905
AGER	TLR4	ENSRROP00000023644	ENSRROP00000017430	Advanced glycosylation end-product specific receptor.	Toll like receptor 4; Belongs to the Toll-like receptor family.	0.466
APP	AGER	ENSRROP00000033171	ENSRROP00000023644	Amyloid beta precursor protein.	Advanced glycosylation end-product specific receptor.	0.644
APP	BTK	ENSRROP00000033171	ENSRROP00000019847	Amyloid beta precursor protein.	Tyrosine-protein kinase.	0.462
APP	CD36	ENSRROP00000033171	ENSRROP00000005762	Amyloid beta precursor protein.	CD36 molecule; Belongs to the CD36 family.	0.487
APP	CLU	ENSRROP00000033171	ENSRROP00000034568	Amyloid beta precursor protein.	Clusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins.	0.885
APP	IL6	ENSRROP00000033171	ENSRROP00000001399	Amyloid beta precursor protein.	Interleukin 6.	0.428
APP	ORM1	ENSRROP00000033171	ENSRROP00000038596	Amyloid beta precursor protein.	Orosomucoid 1.	0.400
APP	PSEN1	ENSRROP00000033171	ENSRROP00000005600	Amyloid beta precursor protein.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.963
APP	STAT3	ENSRROP00000033171	ENSRROP00000018412	Amyloid beta precursor protein.	Signal transducer and activator of transcription.	0.400
AZU1	LBP	ENSRROP00000040676	ENSRROP00000007779	Azurocidin 1.	Lipopolysaccharide binding protein.	0.406
BTK	APP	ENSRROP00000019847	ENSRROP00000033171	Tyrosine-protein kinase.	Amyloid beta precursor protein.	0.462
BTK	MYD88	ENSRROP00000019847	ENSRROP00000009021	Tyrosine-protein kinase.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.716
BTK	PIK3R1	ENSRROP00000019847	ENSRROP00000021473	Tyrosine-protein kinase.	Phosphoinositide-3-kinase regulatory subunit 1.	0.943
BTK	PLCG2	ENSRROP00000019847	ENSRROP00000044220	Tyrosine-protein kinase.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.987
BTK	PTPRC	ENSRROP00000019847	ENSRROP00000022085	Tyrosine-protein kinase.	Protein tyrosine phosphatase receptor type C.	0.405
BTK	SASH3	ENSRROP00000019847	ENSRROP00000010322	Tyrosine-protein kinase.	SAM and SH3 domain containing 3.	0.419