STRINGSTRING
ENSRROP00000039638 ENSRROP00000039638 SIRT6 SIRT6 PASD1 PASD1 ID2 ID2 MC3R MC3R PPARGC1A PPARGC1A CAVIN3 CAVIN3 PML PML MTA1 MTA1 ENSRROP00000005469 ENSRROP00000005469 NR1D1 NR1D1 ID3 ID3 HDAC3 HDAC3 KDM8 KDM8 ENSRROP00000007230 ENSRROP00000007230 NRIP1 NRIP1 ATF4 ATF4 PRMT5 PRMT5 OGT OGT ARNTL2 ARNTL2 HUWE1 HUWE1 PER2 PER2 MYCBP2 MYCBP2 RELB RELB CIART CIART CRY2 CRY2 PPARA PPARA HDAC1 HDAC1 NOCT NOCT PER1 PER1 NGFR NGFR RBM4 RBM4 RBM4B RBM4B HDAC2 HDAC2 GFPT1 GFPT1 ID1 ID1 ENSRROP00000019405 ENSRROP00000019405 SIRT1 SIRT1 CRY1 CRY1 NAMPT NAMPT CLOCK CLOCK ARNTL ARNTL NPAS2 NPAS2 RAI1 RAI1 PPP1CB PPP1CB BHLHE41 BHLHE41 LOC104677352 LOC104677352 ENSRROP00000030430 ENSRROP00000030430 MYBBP1A MYBBP1A BHLHE40 BHLHE40 PPP1CA PPP1CA ZFHX3 ZFHX3 CSNK1E CSNK1E MAGED1 MAGED1 NCOA2 NCOA2 RORC RORC NUDT12 NUDT12 ID4 ID4 CARTPT CARTPT USP2 USP2 HNRNPU HNRNPU CSNK1D CSNK1D NR0B2 NR0B2 TOP1 TOP1 KDM5A KDM5A PER3 PER3 PPP1CC PPP1CC LGR4 LGR4 DRD2 DRD2 RORA RORA EGR1 EGR1 ZPBP2 ZPBP2 KDM2A KDM2A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSRROP00000039638Endo/exonuclease/phosphatase domain-containing protein. (403 aa)
SIRT6Sirtuin 6. (355 aa)
PASD1PAS domain containing repressor 1. (687 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
MC3RMelanocortin 3 receptor. (323 aa)
PPARGC1APPARG coactivator 1 alpha. (798 aa)
CAVIN3Caveolae associated protein 3. (293 aa)
PMLPromyelocytic leukemia. (882 aa)
MTA1Metastasis associated 1. (697 aa)
ENSRROP00000005469Uncharacterized protein. (53 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (613 aa)
ID3Inhibitor of DNA binding 3, HLH protein. (119 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
KDM8Lysine demethylase 8. (454 aa)
ENSRROP00000007230Uncharacterized protein. (193 aa)
NRIP1Nuclear receptor interacting protein 1. (1155 aa)
ATF4Activating transcription factor 4. (351 aa)
PRMT5Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (637 aa)
OGTO-linked N-acetylglucosamine (GlcNAc) transferase. (1046 aa)
ARNTL2Aryl hydrocarbon receptor nuclear translocator like 2. (622 aa)
HUWE1HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1. (4423 aa)
PER2Period circadian regulator 2. (1253 aa)
MYCBP2MYC binding protein 2. (4751 aa)
RELBRELB proto-oncogene, NF-kB subunit. (541 aa)
CIARTCircadian associated repressor of transcription. (385 aa)
CRY2Cryptochrome circadian regulator 2. (614 aa)
PPARAPeroxisome proliferator activated receptor alpha. (398 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (477 aa)
NOCTEndo/exonuclease/phosphatase domain-containing protein. (431 aa)
PER1Period circadian regulator 1. (1292 aa)
NGFRNerve growth factor receptor. (427 aa)
RBM4Uncharacterized protein. (193 aa)
RBM4BRNA binding motif protein 4B. (359 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
GFPT1Glutamine--fructose-6-phosphate transaminase 1. (699 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (154 aa)
ENSRROP00000019405Hist_deacetyl domain-containing protein. (352 aa)
SIRT1Sirtuin 1. (746 aa)
CRY1Cryptochrome circadian regulator 1. (586 aa)
NAMPTNicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (499 aa)
CLOCKClock circadian regulator. (847 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator like. (626 aa)
NPAS2Neuronal PAS domain protein 2. (824 aa)
RAI1Retinoic acid induced 1. (1910 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (373 aa)
BHLHE41Uncharacterized protein. (334 aa)
LOC104677352Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (484 aa)
ENSRROP00000030430Uncharacterized protein. (297 aa)
MYBBP1AMYB binding protein 1a. (1340 aa)
BHLHE40Basic helix-loop-helix family member e40. (412 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (367 aa)
ZFHX3Zinc finger homeobox 3. (3704 aa)
CSNK1EProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (416 aa)
MAGED1MAGE family member D1. (834 aa)
NCOA2Nuclear receptor coactivator. (1475 aa)
RORCRAR related orphan receptor C. (519 aa)
NUDT12Nudix hydrolase 12. (462 aa)
ID4Inhibitor of DNA binding 4, HLH protein. (153 aa)
CARTPTCART prepropeptide. (116 aa)
USP2Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (635 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (806 aa)
CSNK1DCasein kinase 1 delta. (406 aa)
NR0B2Nuclear receptor subfamily 0 group B member 2. (257 aa)
TOP1DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (767 aa)
KDM5ALysine demethylase 5A. (1690 aa)
PER3Period circadian regulator 3. (1178 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (951 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
RORARAR related orphan receptor A. (555 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (541 aa)
ZPBP2Zona pellucida binding protein 2. (337 aa)
KDM2ALysine demethylase 2A. (1162 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.