STRINGSTRING
SMAD7 SMAD7 TGFB1 TGFB1 SMAD6 SMAD6 LRG1 LRG1 SMAD2 SMAD2 FERMT2 FERMT2 ENG ENG TGFBR2 TGFBR2 TGFB3 TGFB3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMAD7MH2 domain-containing protein. (211 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
SMAD6MH2 domain-containing protein. (226 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (347 aa)
SMAD2Mothers against decapentaplegic homolog. (392 aa)
FERMT2Fermitin family member 2. (695 aa)
ENGEndoglin. (658 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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