STRINGSTRING
CTNNB1 CTNNB1 PTCH1 PTCH1 SEMA4C SEMA4C HIF1A HIF1A DAB2IP DAB2IP STK3 STK3 GRHL2 GRHL2 BMP7 BMP7 LUZP1 LUZP1 EDA-2 EDA-2 SUFU SUFU SFRP2 SFRP2 BBS4 BBS4 BRD2 BRD2 HECTD1 HECTD1 WNT6 WNT6 CEP290 CEP290 HAND1 HAND1 NOG NOG ENSRROP00000004259 ENSRROP00000004259 FGF10 FGF10 IFT52 IFT52 DLC1 DLC1 LOC104657591 LOC104657591 PRKACB PRKACB COBL COBL MIB1 MIB1 IRX1 IRX1 TULP3 TULP3 EDA EDA OSR1 OSR1 IRX2 IRX2 SETD2 SETD2 CLUAP1 CLUAP1 TBXT TBXT STIL STIL HS2ST1 HS2ST1 MTHFD1L MTHFD1L TCAP TCAP CTHRC1 CTHRC1 GRHL3 GRHL3 SCRIB SCRIB ATOH8 ATOH8 SKI SKI SDCCAG8 SDCCAG8 LMO4 LMO4 GLMN GLMN WNT5A WNT5A SHH SHH GDF7 GDF7 HESX1 HESX1 PROX1 PROX1 LOC104681596 LOC104681596 ABL1 ABL1 OPA1 OPA1 SPINT1 SPINT1 FGFR2 FGFR2 WNT9B WNT9B RARA RARA EDAR EDAR SHANK3 SHANK3 LOC104674202 LOC104674202 IRX3 IRX3 FZD6 FZD6 DVL2 DVL2 RGMA RGMA CC2D2A CC2D2A DVL3 DVL3 SIX1 SIX1 RARG RARG BCAS3 BCAS3 APAF1 APAF1 TGM2 TGM2 GATA3 GATA3 MED12 MED12 ENSRROP00000023796 ENSRROP00000023796 SEC24B SEC24B LRP2 LRP2 ARHGAP35 ARHGAP35 PODXL PODXL WNT4 WNT4 FZD2 FZD2 PAX2 PAX2 ENSRROP00000025671 ENSRROP00000025671 SALL4 SALL4 SOX9 SOX9 LHX2 LHX2 ENSRROP00000027231 ENSRROP00000027231 KAT2A KAT2A FUZ FUZ BCL2L11 BCL2L11 NODAL NODAL IFT57 IFT57 CECR2 CECR2 SOX8 SOX8 FGF8 FGF8 OVOL2 OVOL2 RALA RALA NFIB NFIB CITED2 CITED2 TEAD2 TEAD2 LRRC1 LRRC1 TGFB2 TGFB2 ADM ADM RPS7 RPS7 PRICKLE1 PRICKLE1 TSC1 TSC1 RET RET ENSRROP00000034704 ENSRROP00000034704 PHACTR4 PHACTR4 BMP4 BMP4 SFRP1 SFRP1 TMED2 TMED2 FOLR1 FOLR1 MKS1 MKS1 IFT172 IFT172 FZD3 FZD3 HOXA1 HOXA1 TRAF6 TRAF6 PTK7 PTK7 CELSR1 CELSR1 LIAS LIAS TGFB1 TGFB1 TRIM71 TRIM71 ST14 ST14 TSC2 TSC2 NOTCH1 NOTCH1 VEGFA VEGFA ITGB1BP1 ITGB1BP1 GDNF GDNF IFT122 IFT122 BCL10 BCL10 SDC4 SDC4 SHROOM3 SHROOM3 VASP VASP KDM2B KDM2B DEAF1 DEAF1 KIF20B KIF20B MTHFD1 MTHFD1 MTHFR MTHFR BMP5 BMP5 VANGL2 VANGL2 PLXNB2 PLXNB2 TCTN1 TCTN1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CTNNB1Catenin beta 1. (781 aa)
PTCH1Patched 1. (1448 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (833 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
DAB2IPDAB2 interacting protein. (1189 aa)
STK3Serine/threonine kinase 3. (519 aa)
GRHL2Grainyhead like transcription factor 2. (633 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
LUZP1Leucine zipper protein 1. (1076 aa)
EDA-2Uncharacterized protein. (147 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (514 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
BBS4Bardet-Biedl syndrome 4. (347 aa)
BRD2Uncharacterized protein. (836 aa)
HECTD1HECT domain E3 ubiquitin protein ligase 1. (2610 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa)
CEP290Centrosomal protein 290. (2480 aa)
HAND1Heart and neural crest derivatives expressed 1. (215 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
ENSRROP00000004259TNF receptor-associated factor. (466 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
IFT52Intraflagellar transport 52. (437 aa)
DLC1DLC1 Rho GTPase activating protein. (1528 aa)
LOC10465759140S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (194 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
COBLCordon-bleu WH2 repeat protein. (1308 aa)
MIB1Mindbomb E3 ubiquitin protein ligase 1. (1006 aa)
IRX1Iroquois homeobox 1. (480 aa)
TULP3TUB like protein 3; Belongs to the TUB family. (482 aa)
EDAEctodysplasin A; Belongs to the tumor necrosis factor family. (223 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
IRX2Iroquois homeobox 2. (453 aa)
SETD2SET domain containing 2, histone lysine methyltransferase. (2563 aa)
CLUAP1Clusterin associated protein 1. (433 aa)
TBXTT-box transcription factor T. (435 aa)
STILSTIL centriolar assembly protein. (1288 aa)
HS2ST1Heparan sulfate 2-O-sulfotransferase 1. (356 aa)
MTHFD1LMethylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (980 aa)
TCAPTitin-cap. (167 aa)
CTHRC1Collagen triple helix repeat containing 1. (243 aa)
GRHL3Grainyhead like transcription factor 3. (608 aa)
SCRIBScribble planar cell polarity protein. (1660 aa)
ATOH8Atonal bHLH transcription factor 8. (364 aa)
SKISKI proto-oncogene. (770 aa)
SDCCAG8Serologically defined colon cancer antigen 8. (712 aa)
LMO4LIM domain only 4. (165 aa)
GLMNGlomulin, FKBP associated protein. (594 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
SHHHH_signal domain-containing protein. (141 aa)
GDF7Growth differentiation factor 7. (450 aa)
HESX1HESX homeobox 1. (185 aa)
PROX1Prospero homeobox 1. (737 aa)
LOC10468159640S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (179 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
OPA1OPA1 mitochondrial dynamin like GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (1015 aa)
SPINT1Serine peptidase inhibitor, Kunitz type 1. (531 aa)
FGFR2Fibroblast growth factor receptor. (837 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
RARARetinoic acid receptor alpha. (478 aa)
EDAREctodysplasin A receptor. (480 aa)
SHANK3SH3 and multiple ankyrin repeat domains 3. (1576 aa)
LOC104674202PID domain-containing protein. (184 aa)
IRX3Iroquois homeobox 3. (501 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
RGMARepulsive guidance molecule BMP co-receptor a. (458 aa)
CC2D2ACoiled-coil and C2 domain containing 2A. (1620 aa)
DVL3Dishevelled segment polarity protein 3. (718 aa)
SIX1SIX homeobox 1. (284 aa)
RARGRetinoic acid receptor gamma. (456 aa)
BCAS3BCAS3 microtubule associated cell migration factor. (950 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
TGM2Transglutaminase 2. (731 aa)
GATA3GATA binding protein 3. (444 aa)
MED12Med12-PQL domain-containing protein. (323 aa)
ENSRROP00000023796Uncharacterized protein. (778 aa)
SEC24BSEC24 homolog B, COPII coat complex component. (690 aa)
LRP2LDL receptor related protein 2. (4655 aa)
ARHGAP35Rho GTPase activating protein 35. (1499 aa)
PODXLPodocalyxin; Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Belongs to the podocalyxin family. (520 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (345 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (571 aa)
PAX2Paired box 2. (417 aa)
ENSRROP0000002567140S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (184 aa)
SALL4Spalt like transcription factor 4. (1053 aa)
SOX9SRY-box transcription factor 9. (509 aa)
LHX2LIM homeobox 2. (406 aa)
ENSRROP00000027231THF_DHG_CYH_C domain-containing protein. (885 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (806 aa)
FUZFuzzy planar cell polarity protein. (418 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
NODALNodal growth differentiation factor. (347 aa)
IFT57Intraflagellar transport 57. (428 aa)
CECR2CECR2 histone acetyl-lysine reader. (1419 aa)
SOX8SRY-box transcription factor 8. (425 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
OVOL2Ovo like zinc finger 2. (275 aa)
RALARAS like proto-oncogene A. (206 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (561 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (275 aa)
TEAD2TEA domain transcription factor 2. (451 aa)
LRRC1Leucine rich repeat containing 1. (524 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
ADMAdrenomedullin. (184 aa)
RPS740S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (194 aa)
PRICKLE1Prickle planar cell polarity protein 1. (831 aa)
TSC1TSC complex subunit 1. (1163 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1094 aa)
ENSRROP00000034704GOLD domain-containing protein. (105 aa)
PHACTR4Phosphatase and actin regulator. (734 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
TMED2Transmembrane p24 trafficking protein 2. (208 aa)
FOLR1Folate receptor alpha. (257 aa)
MKS1MKS transition zone complex subunit 1. (559 aa)
IFT172Intraflagellar transport 172. (1753 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
HOXA1Homeobox A1. (335 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1078 aa)
CELSR1Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (2856 aa)
LIASLipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (372 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
TRIM71Tripartite motif containing 71. (732 aa)
ST14Suppression of tumorigenicity 14. (888 aa)
TSC2TSC complex subunit 2. (1807 aa)
NOTCH1Notch receptor 1. (2560 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
ITGB1BP1PID domain-containing protein. (154 aa)
GDNFGlial cell derived neurotrophic factor. (228 aa)
IFT122Intraflagellar transport 122. (1238 aa)
BCL10BCL10 immune signaling adaptor. (316 aa)
SDC4Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (201 aa)
SHROOM3Shroom family member 3. (1990 aa)
VASPVasodilator stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (380 aa)
KDM2BLysine demethylase 2B. (1330 aa)
DEAF1DEAF1 transcription factor. (565 aa)
KIF20BKinesin family member 20B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1822 aa)
MTHFD1Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1. (984 aa)
MTHFRMethylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (697 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
VANGL2Vang-like protein. (547 aa)
PLXNB2Plexin B2. (1833 aa)
TCTN1Tectonic family member 1. (587 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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