STRINGSTRING
MAPK8IP1 MAPK8IP1 IGFBP2 IGFBP2 IL21 IL21 LOC104671192 LOC104671192 IL6 IL6 CD80 CD80 RPS3 RPS3 ENSRROP00000003001 ENSRROP00000003001 TGFBR2 TGFBR2 SH3RF1 SH3RF1 ENSRROP00000004259 ENSRROP00000004259 PLA2G2F PLA2G2F JAK3 JAK3 MARCHF7 MARCHF7 NCKAP1L NCKAP1L BCL6 BCL6 ENSRROP00000006428 ENSRROP00000006428 IL12RB1 IL12RB1 ZP4 ZP4 NCK2 NCK2 CTLA4 CTLA4 TFRC TFRC ENSRROP00000008301 ENSRROP00000008301 CD86 CD86 LRRC32 LRRC32 TNFSF8 TNFSF8 CD55 CD55 HAVCR2 HAVCR2 VCAM1 VCAM1 IL2 IL2 CCL19 CCL19 LMO1 LMO1 DLG5 DLG5 CD24 CD24 IGF2 IGF2 SASH3 SASH3 GPAM GPAM JAK2 JAK2 PTPN22 PTPN22 STAT5B STAT5B ITCH ITCH CRTAM CRTAM TYK2 TYK2 CD3E CD3E RASAL3 RASAL3 DLG1 DLG1 SOS1 SOS1 SCRIB SCRIB PTEN PTEN EFNB1 EFNB1 LILRB4 LILRB4 PNP PNP GLMN GLMN SHH SHH AIF1 AIF1 CD276 CD276 LOC104676775 LOC104676775 ZBTB7B ZBTB7B CD274 CD274 ENSRROP00000017558 ENSRROP00000017558 ENSRROP00000017761 ENSRROP00000017761 TNFRSF21 TNFRSF21 LEP LEP CLECL1 CLECL1 VSIG4 VSIG4 HHLA2 HHLA2 SYK SYK VTCN1 VTCN1 ARG2 ARG2 CARD11 CARD11 PELI1 PELI1 IL15 IL15 PTPRC PTPRC ARG1 ARG1 PRKCQ PRKCQ AGER AGER BID BID DNAJA3 DNAJA3 LGALS7 LGALS7 SLC7A1 SLC7A1 KITLG KITLG PDCD1LG2 PDCD1LG2 HLA-DPB1 HLA-DPB1 IL27RA IL27RA TSPAN32 TSPAN32 IGF1 IGF1 RC3H1 RC3H1 ICOSLG ICOSLG LOC104668202 LOC104668202 TNFRSF14 TNFRSF14 SOS2 SOS2 ENSRROP00000026782 ENSRROP00000026782 HLA-DPA1 HLA-DPA1 SPTA1 SPTA1 PRNP PRNP SLAMF1 SLAMF1 PTPN6 PTPN6 PDE5A PDE5A TNFRSF1B TNFRSF1B IL4I1 IL4I1 FOXP3 FOXP3 IL12RB2 IL12RB2 CTNNB1 CTNNB1 TNFSF4 TNFSF4 CD1D CD1D TMIGD2 TMIGD2 TNFSF13B TNFSF13B LOC104668444 LOC104668444 TNFSF18 TNFSF18 LRRC1 LRRC1 ENSRROP00000032658 ENSRROP00000032658 IL6ST IL6ST PLA2G2D PLA2G2D DHPS DHPS VSIR VSIR CD70 CD70 IL1B IL1B ZAP70 ZAP70 FADD FADD TNFRSF9 TNFRSF9 LOC104655335 LOC104655335 CD40LG CD40LG TMEM131L TMEM131L NDFIP1 NDFIP1 LGALS3 LGALS3 CD209 CD209 IRF1 IRF1 FOXJ1 FOXJ1 BMP4 BMP4 LOC104672488 LOC104672488 CORO1A CORO1A TNFRSF13C TNFRSF13C ANXA1 ANXA1 CLEC4G CLEC4G TRAF6 TRAF6 HLA-E HLA-E GPNMB GPNMB RAC2 RAC2 PYCARD PYCARD TGFB1 TGFB1 IHH IHH TNFSF9 TNFSF9 CD81 CD81 CBLB CBLB IL23R IL23R CD28 CD28 MAD1L1 MAD1L1 RIPK3 RIPK3 IL18 IL18 IL20RB IL20RB IDO1 IDO1 SDC4 SDC4 NCK1 NCK1 ENSRROP00000043101 ENSRROP00000043101 IL27 IL27 PAWR PAWR ERBB2 ERBB2 CCDC88B CCDC88B CD6 CD6 LOC104663345 LOC104663345 IL23A IL23A PPP3CA PPP3CA TWSG1 TWSG1 RIPK2 RIPK2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK8IP1Mitogen-activated protein kinase 8 interacting protein 1. (735 aa)
IGFBP2Insulin like growth factor binding protein 2. (325 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
LOC104671192Galectin. (248 aa)
IL6Interleukin 6. (214 aa)
CD80CD80 molecule. (288 aa)
RPS3Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
ENSRROP00000003001Uncharacterized protein. (93 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
SH3RF1SH3 domain containing ring finger 1. (890 aa)
ENSRROP00000004259TNF receptor-associated factor. (466 aa)
PLA2G2FPhospholipase A(2). (210 aa)
JAK3Tyrosine-protein kinase. (1124 aa)
MARCHF7Membrane associated ring-CH-type finger 7. (704 aa)
NCKAP1LNCK associated protein 1 like. (1134 aa)
BCL6BCL6 transcription repressor. (706 aa)
ENSRROP00000006428Uncharacterized protein. (70 aa)
IL12RB1Interleukin 12 receptor subunit beta 1. (661 aa)
ZP4Zona pellucida glycoprotein 4. (539 aa)
NCK2Cytoplasmic protein. (382 aa)
CTLA4Cytotoxic T-lymphocyte associated protein 4. (223 aa)
TFRCTransferrin receptor. (760 aa)
ENSRROP00000008301Galectin. (200 aa)
CD86CD86 molecule. (329 aa)
LRRC32Leucine rich repeat containing 32. (662 aa)
TNFSF8TNF superfamily member 8; Belongs to the tumor necrosis factor family. (234 aa)
CD55CD55 molecule (Cromer blood group). (540 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (293 aa)
VCAM1Vascular cell adhesion molecule 1. (739 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
CCL19C-C motif chemokine. (98 aa)
LMO1LIM domain only 1. (156 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1919 aa)
CD24Uncharacterized protein. (127 aa)
IGF2Insulin like growth factor 2. (236 aa)
SASH3SAM and SH3 domain containing 3. (380 aa)
GPAMGlycerol-3-phosphate acyltransferase 1, mitochondrial. (828 aa)
JAK2Tyrosine-protein kinase. (1094 aa)
PTPN22Protein tyrosine phosphatase non-receptor type 22. (813 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
ITCHE3 ubiquitin-protein ligase. (862 aa)
CRTAMCytotoxic and regulatory T cell molecule. (393 aa)
TYK2Tyrosine-protein kinase. (1187 aa)
CD3ECD3e molecule. (198 aa)
RASAL3RAS protein activator like 3. (1011 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (926 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
SCRIBScribble planar cell polarity protein. (1660 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
EFNB1Ephrin B1; Belongs to the ephrin family. (346 aa)
LILRB4Leukocyte immunoglobulin like receptor B4. (471 aa)
PNPPurine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (289 aa)
GLMNGlomulin, FKBP associated protein. (594 aa)
SHHHH_signal domain-containing protein. (141 aa)
AIF1Allograft inflammatory factor 1. (147 aa)
CD276CD276 molecule. (496 aa)
LOC104676775Ig-like domain-containing protein; Belongs to the MHC class I family. (391 aa)
ZBTB7BZinc finger and BTB domain containing 7B. (573 aa)
CD274CD274 molecule. (290 aa)
ENSRROP00000017558Uncharacterized protein. (78 aa)
ENSRROP00000017761KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (269 aa)
TNFRSF21TNF receptor superfamily member 21. (655 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
CLECL1Uncharacterized protein. (162 aa)
VSIG4V-set and immunoglobulin domain containing 4. (399 aa)
HHLA2HERV-H LTR-associating 2. (419 aa)
SYKTyrosine-protein kinase. (635 aa)
VTCN1V-set domain containing T cell activation inhibitor 1. (285 aa)
ARG2Arginase. (354 aa)
CARD11Caspase recruitment domain family member 11. (1154 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1311 aa)
ARG1Arginase. (322 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (710 aa)
AGERAdvanced glycosylation end-product specific receptor. (403 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (226 aa)
DNAJA3DnaJ heat shock protein family (Hsp40) member A3. (480 aa)
LGALS7Galectin. (110 aa)
SLC7A1Solute carrier family 7 member 1. (629 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
PDCD1LG2Programmed cell death 1 ligand 2. (273 aa)
HLA-DPB1Major histocompatibility complex, class II, DP beta 1. (258 aa)
IL27RAInterleukin 27 receptor subunit alpha. (636 aa)
TSPAN32Tetraspanin 32; Belongs to the tetraspanin (TM4SF) family. (319 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (208 aa)
RC3H1Ring finger and CCCH-type domains 1. (1133 aa)
ICOSLGUncharacterized protein. (275 aa)
LOC104668202Galectin-3. (248 aa)
TNFRSF14TNF receptor superfamily member 14. (283 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
ENSRROP00000026782KH type-2 domain-containing protein. (133 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (305 aa)
SPTA1Spectrin alpha, erythrocytic 1. (2427 aa)
PRNPMajor prion protein; Belongs to the prion family. (230 aa)
SLAMF1Signaling lymphocytic activation molecule family member 1. (357 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
PDE5APhosphodiesterase. (875 aa)
TNFRSF1BTNF receptor superfamily member 1B. (462 aa)
IL4I1Amine oxidase. (579 aa)
FOXP3Forkhead box P3. (454 aa)
IL12RB2Interleukin 12 receptor subunit beta 2. (863 aa)
CTNNB1Catenin beta 1. (781 aa)
TNFSF4TNF superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa)
CD1DCD1d molecule. (337 aa)
TMIGD2Transmembrane and immunoglobulin domain containing 2. (275 aa)
TNFSF13BTNF superfamily member 13b; Belongs to the tumor necrosis factor family. (285 aa)
LOC104668444Ribosomal_S3_C domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (251 aa)
TNFSF18TNF superfamily member 18. (199 aa)
LRRC1Leucine rich repeat containing 1. (524 aa)
ENSRROP00000032658KH type-2 domain-containing protein. (143 aa)
IL6STInterleukin 6 signal transducer. (943 aa)
PLA2G2DPhospholipase A(2). (145 aa)
DHPSUncharacterized protein. (379 aa)
VSIRV-set immunoregulatory receptor. (359 aa)
CD70CD70 molecule; Belongs to the tumor necrosis factor family. (194 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
TNFRSF9TNF receptor superfamily member 9. (254 aa)
LOC104655335Uncharacterized protein. (511 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
TMEM131LTransmembrane 131 like. (1621 aa)
NDFIP1Nedd4 family interacting protein 1. (221 aa)
LGALS3Galectin. (252 aa)
CD209CD209 molecule. (379 aa)
IRF1Interferon regulatory factor. (325 aa)
FOXJ1Forkhead box J1. (386 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
LOC104672488Galectin. (218 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
TNFRSF13CTNF receptor superfamily member 13C. (167 aa)
ANXA1Annexin. (346 aa)
CLEC4GC-type lectin domain family 4 member G. (293 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
HLA-EMajor histocompatibility complex, class I, E; Belongs to the MHC class I family. (364 aa)
GPNMBGlycoprotein nmb. (561 aa)
RAC2Rac family small GTPase 2. (192 aa)
PYCARDPYD and CARD domain containing. (195 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
TNFSF9TNF superfamily member 9; Belongs to the tumor necrosis factor family. (251 aa)
CD81Tetraspanin. (274 aa)
CBLBCbl proto-oncogene B. (982 aa)
IL23RInterleukin 23 receptor. (629 aa)
CD28CD28 molecule. (220 aa)
MAD1L1Mitotic arrest deficient 1 like 1. (718 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (518 aa)
IL18Interleukin 18. (211 aa)
IL20RBInterleukin 20 receptor subunit beta. (311 aa)
IDO1Indoleamine 2,3-dioxygenase 1. (402 aa)
SDC4Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (201 aa)
NCK1Cytoplasmic protein. (377 aa)
ENSRROP00000043101Ig-like domain-containing protein. (244 aa)
IL27Interleukin 27. (245 aa)
PAWRPro-apoptotic WT1 regulator. (340 aa)
ERBB2Receptor protein-tyrosine kinase. (1352 aa)
CCDC88BCoiled-coil domain containing 88B. (1476 aa)
CD6CD6 molecule. (668 aa)
LOC104663345Uncharacterized protein. (518 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
PPP3CASerine/threonine-protein phosphatase. (417 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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