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CX3CL1 | C-X3-C motif chemokine ligand 1. (407 aa) | ||||
TRADD | TNFRSF1A associated via death domain. (353 aa) | ||||
CCDC22 | Coiled-coil domain containing 22. (627 aa) | ||||
DAB2IP | DAB2 interacting protein. (1189 aa) | ||||
TRIM6 | Tripartite motif containing 6. (498 aa) | ||||
USP10 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (802 aa) | ||||
LOC104655302 | SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (205 aa) | ||||
TLR3 | Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa) | ||||
ATP2C1 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (983 aa) | ||||
IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa) | ||||
EDA-2 | Uncharacterized protein. (147 aa) | ||||
NOD1 | Nucleotide binding oligomerization domain containing 1. (953 aa) | ||||
UBD | Ubiquitin D. (165 aa) | ||||
GOLT1B | Golgi transport 1B. (138 aa) | ||||
PDPK1 | 3-phosphoinositide dependent protein kinase 1. (356 aa) | ||||
OTUD7B | OTU deubiquitinase 7B. (843 aa) | ||||
LIME1 | Uncharacterized protein. (292 aa) | ||||
RELA | RELA proto-oncogene, NF-kB subunit. (551 aa) | ||||
ENSRROP00000004259 | TNF receptor-associated factor. (466 aa) | ||||
WDR83 | WD repeat domain 83. (346 aa) | ||||
S100A13 | S100 calcium binding protein A13; Belongs to the S-100 family. (98 aa) | ||||
ENSRROP00000004615 | PB1 domain-containing protein. (147 aa) | ||||
ASH1L | ASH1 like histone lysine methyltransferase. (2916 aa) | ||||
RHOH | Ras homolog family member H. (191 aa) | ||||
ENSRROP00000005569 | Uncharacterized protein. (601 aa) | ||||
ENSRROP00000005613 | LITAF domain-containing protein. (162 aa) | ||||
NR1D1 | Nuclear receptor subfamily 1 group D member 1. (613 aa) | ||||
NOD2 | Nucleotide binding oligomerization domain containing 2. (1040 aa) | ||||
CD36 | CD36 molecule; Belongs to the CD36 family. (472 aa) | ||||
TRIM32 | Tripartite motif containing 32. (653 aa) | ||||
ENSRROP00000005829 | Uncharacterized protein. (90 aa) | ||||
LOC104665503 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) | ||||
ENSRROP00000006347 | Uncharacterized protein. (76 aa) | ||||
TIFA | TRAF interacting protein with forkhead associated domain. (185 aa) | ||||
PPP5C | Serine/threonine-protein phosphatase. (499 aa) | ||||
REL | REL proto-oncogene, NF-kB subunit. (602 aa) | ||||
CD4 | CD4 molecule. (458 aa) | ||||
TNFSF10 | Tumor necrosis factor ligand superfamily member. (281 aa) | ||||
TFRC | Transferrin receptor. (760 aa) | ||||
TNFSF11 | Tumor necrosis factor ligand superfamily member. (317 aa) | ||||
MUL1 | Mitochondrial E3 ubiquitin protein ligase 1. (352 aa) | ||||
MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa) | ||||
TAB2 | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa) | ||||
TNFRSF1A | TNF receptor superfamily member 1A. (455 aa) | ||||
PRKCE | Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa) | ||||
TRAF4 | TNF receptor-associated factor. (469 aa) | ||||
CCL19 | C-C motif chemokine. (98 aa) | ||||
PPM1N | Protein phosphatase, Mg2+/Mn2+ dependent 1N (putative). (430 aa) | ||||
TLE1 | TLE family member 1, transcriptional corepressor. (770 aa) | ||||
EDA | Ectodysplasin A; Belongs to the tumor necrosis factor family. (223 aa) | ||||
ANKRD17 | Ankyrin repeat domain 17. (2603 aa) | ||||
LTF | Lactotransferrin; Belongs to the transferrin family. (732 aa) | ||||
TRIM38 | Tripartite motif containing 38. (465 aa) | ||||
PRKN | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa) | ||||
LOC104662518 | RING-type domain-containing protein. (377 aa) | ||||
S100B | S_100 domain-containing protein; Belongs to the S-100 family. (94 aa) | ||||
PELI2 | E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (407 aa) | ||||
ENSRROP00000011088 | G_PROTEIN_RECEP_F1_2 domain-containing protein. (349 aa) | ||||
ECM1 | Extracellular matrix protein 1. (540 aa) | ||||
LOC104657019 | Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (396 aa) | ||||
BTRC | Beta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa) | ||||
NUP62 | Nucleoporin 62. (442 aa) | ||||
NKIRAS2 | NFKB inhibitor interacting Ras like 2. (231 aa) | ||||
TRIM8 | Tripartite motif containing 8. (551 aa) | ||||
GAPDH | Glyceraldehyde-3-phosphate dehydrogenase. (335 aa) | ||||
TRIM14 | Tripartite motif containing 14. (433 aa) | ||||
TRIM62 | Tripartite motif containing 62. (470 aa) | ||||
TMEM101 | Transmembrane protein 101. (257 aa) | ||||
CASP8 | Caspase 8; Belongs to the peptidase C14A family. (542 aa) | ||||
MAVS | CARD_2 domain-containing protein. (545 aa) | ||||
TRAF3IP2 | TRAF3 interacting protein 2. (572 aa) | ||||
ADIPOQ | Adiponectin, C1Q and collagen domain containing. (244 aa) | ||||
DDX1 | DEAD-box helicase 1. (740 aa) | ||||
PRKD1 | Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (895 aa) | ||||
TFG | Trafficking from ER to golgi regulator. (400 aa) | ||||
NFKBIB | NFKB inhibitor beta. (356 aa) | ||||
LILRB4 | Leukocyte immunoglobulin like receptor B4. (471 aa) | ||||
NLRP6 | NLR family pyrin domain containing 6. (1041 aa) | ||||
MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (616 aa) | ||||
CARD19 | Caspase recruitment domain family member 19. (183 aa) | ||||
RHOA | Ras homolog family member A. (193 aa) | ||||
HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (477 aa) | ||||
ENSRROP00000015516 | Helicase C-terminal domain-containing protein. (319 aa) | ||||
TSPAN6 | Tetraspanin. (245 aa) | ||||
WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa) | ||||
DDX50 | DExD-box helicase 50. (737 aa) | ||||
TREM2 | Triggering receptor expressed on myeloid cells 2. (230 aa) | ||||
S100A4 | Protein S100; Belongs to the S-100 family. (101 aa) | ||||
ENSRROP00000016384 | Uncharacterized protein. (170 aa) | ||||
ABL1 | Tyrosine-protein kinase. (1149 aa) | ||||
CACTIN | Cactin, spliceosome C complex subunit. (724 aa) | ||||
MTDH | Metadherin. (582 aa) | ||||
JMJD8 | Jumonji domain containing 8. (285 aa) | ||||
MID2 | Midline 2. (735 aa) | ||||
PER1 | Period circadian regulator 1. (1292 aa) | ||||
TLR4 | Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa) | ||||
TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (519 aa) | ||||
EDAR | Ectodysplasin A receptor. (480 aa) | ||||
DDX21 | DExD-box helicase 21. (783 aa) | ||||
FYN | Tyrosine-protein kinase. (537 aa) | ||||
CCL21 | C-C motif chemokine ligand 21. (131 aa) | ||||
ZMYND11 | Zinc finger MYND-type containing 11. (635 aa) | ||||
IRF3 | IRF tryptophan pentad repeat domain-containing protein. (426 aa) | ||||
ENSRROP00000019405 | Hist_deacetyl domain-containing protein. (352 aa) | ||||
ALPK1 | Alpha kinase 1. (1244 aa) | ||||
LPAR1 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (366 aa) | ||||
CLEC6A | C-type lectin domain containing 6A. (209 aa) | ||||
CD74 | CD74 molecule. (294 aa) | ||||
PRKCB | Non-specific serine/threonine protein kinase. (590 aa) | ||||
TRIM13 | Tripartite motif containing 13. (410 aa) | ||||
SIRT1 | Sirtuin 1. (746 aa) | ||||
CARD11 | Caspase recruitment domain family member 11. (1154 aa) | ||||
MAP3K14 | Mitogen-activated protein kinase kinase kinase 14. (947 aa) | ||||
PELI1 | E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa) | ||||
NLRX1 | NLR family member X1. (972 aa) | ||||
TRAF5 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa) | ||||
RIPK1 | Receptor interacting serine/threonine kinase 1. (671 aa) | ||||
OTUD7A | OTU deubiquitinase 7A. (733 aa) | ||||
ENSRROP00000023000 | CCHC NOA-type domain-containing protein. (352 aa) | ||||
PIM2 | Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (311 aa) | ||||
RHOC | Ras homolog family member C. (193 aa) | ||||
ECT2 | Uncharacterized protein. (571 aa) | ||||
SECTM1 | Secreted and transmembrane 1. (242 aa) | ||||
TRIM27 | Tripartite motif containing 27. (513 aa) | ||||
TRIM21 | Tripartite motif containing 21. (475 aa) | ||||
DNAJA3 | DnaJ heat shock protein family (Hsp40) member A3. (480 aa) | ||||
TNIP3 | TNFAIP3 interacting protein 3. (377 aa) | ||||
IKBKE | Inhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa) | ||||
SPHK2 | Sphingosine kinase 2. (665 aa) | ||||
TRIM22 | Tripartite motif containing 22. (498 aa) | ||||
ENSRROP00000024190 | Protein kinase domain-containing protein. (137 aa) | ||||
INAVA | Innate immunity activator. (663 aa) | ||||
LGALS1 | Galectin. (135 aa) | ||||
F2R | Coagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (425 aa) | ||||
SQSTM1 | Sequestosome 1. (451 aa) | ||||
TMEM106A | Transmembrane protein 106A. (262 aa) | ||||
IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (789 aa) | ||||
ENSRROP00000025234 | Uncharacterized protein. (106 aa) | ||||
TICAM1 | Toll like receptor adaptor molecule 1. (522 aa) | ||||
CD40 | CD40 molecule. (278 aa) | ||||
TNIP1 | TNFAIP3 interacting protein 1. (637 aa) | ||||
DHX36 | DEAH-box helicase 36. (1008 aa) | ||||
ENSRROP00000025491 | Gp_dh_N domain-containing protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (263 aa) | ||||
TRIM39 | Tripartite motif containing 39. (518 aa) | ||||
IRAK4 | Interleukin 1 receptor associated kinase 4. (460 aa) | ||||
ENSRROP00000025981 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (140 aa) | ||||
LOC104678031 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) | ||||
TRIM5 | Uncharacterized protein. (495 aa) | ||||
TRIM25 | Tripartite motif containing 25. (630 aa) | ||||
PLEKHG5 | Pleckstrin homology and RhoGEF domain containing G5. (1083 aa) | ||||
ZC3H12A | Zinc finger CCCH-type containing 12A. (601 aa) | ||||
ENSRROP00000027324 | Uncharacterized protein. (417 aa) | ||||
CARD9 | Caspase recruitment domain family member 9. (536 aa) | ||||
LOC104680738 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) | ||||
RBCK1 | RANBP2-type and C3HC4-type zinc finger containing 1. (510 aa) | ||||
MALT1 | MALT1 paracaspase. (774 aa) | ||||
TRIM34 | Uncharacterized protein. (488 aa) | ||||
TRIML1 | Tripartite motif family like 1. (468 aa) | ||||
NLRC3 | NLR family CARD domain containing 3. (1066 aa) | ||||
LOC104677352 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (484 aa) | ||||
UBE2N | Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) | ||||
MAPKBP1 | Mitogen-activated protein kinase binding protein 1. (1514 aa) | ||||
CCR7 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (378 aa) | ||||
CTNNB1 | Catenin beta 1. (781 aa) | ||||
DHX15 | DEAH-box helicase 15. (795 aa) | ||||
HTR2B | 5-hydroxytryptamine receptor 2B. (481 aa) | ||||
PINK1 | PTEN induced kinase 1. (581 aa) | ||||
LOC104665273 | Uncharacterized protein; Belongs to the peptidase C14A family. (406 aa) | ||||
BIRC3 | Baculoviral IAP repeat containing 3. (638 aa) | ||||
CAPN3 | Calpain 3; Belongs to the peptidase C2 family. (826 aa) | ||||
HSPB1 | SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (205 aa) | ||||
BIRC2 | Baculoviral IAP repeat containing 2. (618 aa) | ||||
ZDHHC17 | Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (632 aa) | ||||
NDFIP2 | Nedd4 family interacting protein 2. (336 aa) | ||||
TRIML2 | Tripartite motif family like 2. (247 aa) | ||||
LOC104673998 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (154 aa) | ||||
AJUBA | Ajuba LIM protein. (538 aa) | ||||
ROR1 | Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (925 aa) | ||||
TMEM9B | TMEM9 domain family member B. (198 aa) | ||||
STAT1 | Signal transducer and activator of transcription. (787 aa) | ||||
NR1H4 | Nuclear receptor subfamily 1 group H member 4. (486 aa) | ||||
MAP3K3 | Mitogen-activated protein kinase kinase kinase 3. (647 aa) | ||||
TERF2IP | TERF2 interacting protein. (400 aa) | ||||
LOC104660903 | IRF-3 domain-containing protein. (342 aa) | ||||
ECT2-2 | Uncharacterized protein. (182 aa) | ||||
IL1B | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa) | ||||
NEK6 | NIMA related kinase 6. (369 aa) | ||||
FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa) | ||||
UFL1 | UFM1 specific ligase 1. (469 aa) | ||||
LITAF | LITAF domain-containing protein. (161 aa) | ||||
SHARPIN | SHANK associated RH domain interactor. (384 aa) | ||||
TMED4 | Transmembrane p24 trafficking protein 4. (227 aa) | ||||
FASLG | Fas ligand; Belongs to the tumor necrosis factor family. (280 aa) | ||||
NDFIP1 | Nedd4 family interacting protein 1. (221 aa) | ||||
FLNA | Filamin A. (2647 aa) | ||||
TNFAIP3 | TNF alpha induced protein 3. (790 aa) | ||||
ENSRROP00000036403 | PPM-type phosphatase domain-containing protein. (342 aa) | ||||
CTH | Cystathionine gamma-lyase. (405 aa) | ||||
ENSRROP00000036642 | Phorbol-ester/DAG-type domain-containing protein. (57 aa) | ||||
LTBR | Lymphotoxin beta receptor. (461 aa) | ||||
LOC104656834 | Uncharacterized protein. (76 aa) | ||||
BST2 | Bone marrow stromal cell antigen 2. (182 aa) | ||||
EDA2R | Ectodysplasin A2 receptor. (289 aa) | ||||
TANK | TRAF family member associated NFKB activator. (457 aa) | ||||
TAB3 | TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (712 aa) | ||||
CASP1 | Caspase 1; Belongs to the peptidase C14A family. (404 aa) | ||||
ZC3HAV1 | Zinc finger CCCH-type containing, antiviral 1. (904 aa) | ||||
TRIM68 | Uncharacterized protein. (485 aa) | ||||
CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa) | ||||
OPTN | Optineurin. (570 aa) | ||||
PPM1A | Protein phosphatase, Mg2+/Mn2+ dependent 1A. (455 aa) | ||||
TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa) | ||||
S100A12 | S100 calcium binding protein A12. (76 aa) | ||||
IRAK1 | Interleukin 1 receptor associated kinase 1. (707 aa) | ||||
ENSRROP00000039739 | Uncharacterized protein. (89 aa) | ||||
TNFRSF19 | TNF receptor superfamily member 19. (416 aa) | ||||
PYCARD | PYD and CARD domain containing. (195 aa) | ||||
TBK1 | TANK binding kinase 1. (729 aa) | ||||
CANT1 | Calcium activated nucleotidase 1. (401 aa) | ||||
LOC104662867 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (112 aa) | ||||
CC2D1A | Coiled-coil and C2 domain containing 1A. (999 aa) | ||||
CLEC4D | C-type lectin domain family 4 member D. (215 aa) | ||||
LURAP1L | Leucine rich adaptor protein 1 like. (226 aa) | ||||
GPRC5B | G protein-coupled receptor class C group 5 member B. (549 aa) | ||||
UBE2I | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. (231 aa) | ||||
ANGPT1 | Angiopoietin 1. (498 aa) | ||||
MIB2 | Mindbomb E3 ubiquitin protein ligase 2. (1034 aa) | ||||
BCL10 | BCL10 immune signaling adaptor. (316 aa) | ||||
RORA | RAR related orphan receptor A. (555 aa) | ||||
LAMTOR5 | Uncharacterized protein. (169 aa) | ||||
TRIM59 | Uncharacterized protein. (323 aa) | ||||
AKAP13 | A-kinase anchoring protein 13. (2874 aa) | ||||
TRIM52 | Tripartite motif containing 52. (280 aa) | ||||
TRAF1 | TNF receptor-associated factor. (416 aa) | ||||
UNC5CL | Unc-5 family C-terminal like. (518 aa) | ||||
CASP10 | Caspase 10; Belongs to the peptidase C14A family. (522 aa) | ||||
CLEC7A | C-type lectin domain containing 7A. (247 aa) | ||||
RNF31 | Uncharacterized protein. (1072 aa) | ||||
LOC104678360 | Nuclear receptor domain-containing protein. (231 aa) | ||||
TRAF3 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa) | ||||
PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa) | ||||
PPM1B | Protein phosphatase, Mg2+/Mn2+ dependent 1B. (479 aa) | ||||
TIRAP | TIR domain containing adaptor protein. (219 aa) | ||||
NLRP12 | NLR family pyrin domain containing 12. (1004 aa) | ||||
TNIP2 | TNFAIP3 interacting protein 2. (366 aa) | ||||
BRD4 | Bromodomain containing 4. (1314 aa) | ||||
PIDD1 | P53-induced death domain protein 1. (910 aa) | ||||
LURAP1 | Leucine rich adaptor protein 1. (237 aa) | ||||
RIOK3 | Serine/threonine-protein kinase RIO3; Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. (598 aa) | ||||
RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa) |