STRINGSTRING
TOM1L2 TOM1L2 FAF2 FAF2 ENSRROP00000000820 ENSRROP00000000820 CKS1B CKS1B LOC104655302 LOC104655302 TSG101 TSG101 IKBKG IKBKG UBAP1L UBAP1L NEDD4 NEDD4 NPLOC4 NPLOC4 UBXN11 UBXN11 ADRM1 ADRM1 GGA1 GGA1 MARCHF7 MARCHF7 TRIM32 TRIM32 LOC104665503 LOC104665503 SMAD3 SMAD3 LOC104660852 LOC104660852 DNAJB2 DNAJB2 UBE2L6 UBE2L6 TAB2 TAB2 PRKN PRKN TEPSIN TEPSIN NUP62 NUP62 STAM2 STAM2 MVB12A MVB12A WDR92 WDR92 RNF185 RNF185 N4BP2L1 N4BP2L1 FBXO7 FBXO7 TOM1L1 TOM1L1 OTUB2 OTUB2 ARMC9 ARMC9 NBR1 NBR1 AUP1 AUP1 GGA3 GGA3 TOP2A TOP2A SMARCAD1 SMARCAD1 CCDC197 CCDC197 FAF1 FAF1 USP25 USP25 SQSTM1 SQSTM1 UBXN2A UBXN2A STAM STAM UBXN10 UBXN10 ENSRROP00000025981 ENSRROP00000025981 LOC104678031 LOC104678031 UBXN8 UBXN8 PLAA PLAA N4BP1 N4BP1 VPS28 VPS28 LOC104680738 LOC104680738 FAAP20 FAAP20 RBCK1 RBCK1 ZFAND2B ZFAND2B ENSRROP00000029707 ENSRROP00000029707 RNF19B RNF19B UBE2N UBE2N ASCC2 ASCC2 USP16 USP16 ILRUN ILRUN HSPB1 HSPB1 BIRC2 BIRC2 CKS2 CKS2 LOC104673998 LOC104673998 UBXN2B UBXN2B RAD23A RAD23A TOM1 TOM1 TP53INP2 TP53INP2 ENSRROP00000033818 ENSRROP00000033818 N4BP2 N4BP2 TOLLIP TOLLIP UBXN1 UBXN1 UBR5 UBR5 ENSRROP00000034976 ENSRROP00000034976 HGS HGS UBAP1 UBAP1 SHARPIN SHARPIN UCHL3 UCHL3 FBXW9 FBXW9 TNFAIP3 TNFAIP3 OTUB1 OTUB1 TAB3 TAB3 GGA2 GGA2 UBXN7 UBXN7 RNF8 RNF8 MARK4 MARK4 RNFT1 RNFT1 JARID2 JARID2 ENSRROP00000039709 ENSRROP00000039709 CUEDC1 CUEDC1 LOC104662867 LOC104662867 UEVLD UEVLD VPS36 VPS36 SPRTN SPRTN HDAC6 HDAC6 RNF168 RNF168 USP5 USP5 BUB3 BUB3 RAD23B RAD23B CUEDC2 CUEDC2 RNF31 RNF31 AMFR AMFR USP13 USP13 FBXW7 FBXW7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TOM1L2Target of myb1 like 2 membrane trafficking protein; Belongs to the TOM1 family. (536 aa)
FAF2Fas associated factor family member 2. (445 aa)
ENSRROP00000000820Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (77 aa)
CKS1BCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
LOC104655302SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (205 aa)
TSG101Tumor susceptibility 101. (390 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa)
UBAP1LUbiquitin associated protein 1 like. (340 aa)
NEDD4NEDD4 E3 ubiquitin protein ligase. (1083 aa)
NPLOC4NPL4 homolog, ubiquitin recognition factor. (616 aa)
UBXN11UBX domain protein 11. (496 aa)
ADRM1Adhesion regulating molecule 1. (445 aa)
GGA1Golgi associated, gamma adaptin ear containing, ARF binding protein 1. (735 aa)
MARCHF7Membrane associated ring-CH-type finger 7. (704 aa)
TRIM32Tripartite motif containing 32. (653 aa)
LOC104665503UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
SMAD3Mothers against decapentaplegic homolog. (480 aa)
LOC104660852Cyclin-dependent kinases regulatory subunit 1. (79 aa)
DNAJB2DnaJ heat shock protein family (Hsp40) member B2. (324 aa)
UBE2L6Ubiquitin conjugating enzyme E2 L6; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
TEPSINTEPSIN adaptor related protein complex 4 accessory protein. (595 aa)
NUP62Nucleoporin 62. (442 aa)
STAM2Signal transducing adaptor molecule 2. (525 aa)
MVB12AMultivesicular body subunit 12A. (273 aa)
WDR92WD repeat domain 92. (357 aa)
RNF185Ring finger protein 185. (192 aa)
N4BP2L1NEDD4 binding protein 2 like 1. (246 aa)
FBXO7F-box protein 7. (522 aa)
TOM1L1Target of myb1 like 1 membrane trafficking protein; Belongs to the TOM1 family. (440 aa)
OTUB2OTU deubiquitinase, ubiquitin aldehyde binding 2. (235 aa)
ARMC9Armadillo repeat containing 9. (818 aa)
NBR1NBR1 autophagy cargo receptor. (986 aa)
AUP1AUP1 lipid droplet regulating VLDL assembly factor. (410 aa)
GGA3Golgi associated, gamma adaptin ear containing, ARF binding protein 3. (723 aa)
TOP2ADNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1531 aa)
SMARCAD1Uncharacterized protein. (1026 aa)
CCDC197Coiled-coil domain containing 197. (274 aa)
FAF1Fas associated factor 1. (635 aa)
USP25Ubiquitin specific peptidase 25; Belongs to the peptidase C19 family. (1125 aa)
SQSTM1Sequestosome 1. (451 aa)
UBXN2AUBX domain protein 2A. (260 aa)
STAMSignal transducing adaptor molecule. (540 aa)
UBXN10UBX domain protein 10. (204 aa)
ENSRROP00000025981UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (140 aa)
LOC104678031UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
UBXN8UBX domain protein 8. (269 aa)
PLAAPhospholipase A2 activating protein. (795 aa)
N4BP1NEDD4 binding protein 1. (896 aa)
VPS28Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. (231 aa)
LOC104680738UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
FAAP20Uncharacterized protein. (178 aa)
RBCK1RANBP2-type and C3HC4-type zinc finger containing 1. (510 aa)
ZFAND2BZinc finger AN1-type containing 2B. (257 aa)
ENSRROP00000029707Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (64 aa)
RNF19BRBR-type E3 ubiquitin transferase. (533 aa)
UBE2NUbiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
ASCC2Activating signal cointegrator 1 complex subunit 2. (782 aa)
USP16Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. (826 aa)
ILRUNInflammation and lipid regulator with UBA-like and NBR1-like domains. (298 aa)
HSPB1SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (205 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
CKS2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
LOC104673998UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
UBXN2BUBX domain protein 2B. (331 aa)
RAD23ARAD23 homolog A, nucleotide excision repair protein. (369 aa)
TOM1Target of myb1 membrane trafficking protein; Belongs to the TOM1 family. (510 aa)
TP53INP2Tumor protein p53 inducible nuclear protein 2. (220 aa)
ENSRROP00000033818E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (446 aa)
N4BP2NEDD4 binding protein 2. (1770 aa)
TOLLIPToll interacting protein. (282 aa)
UBXN1UBX domain protein 1. (310 aa)
UBR5Ubiquitin protein ligase E3 component n-recognin 5. (2794 aa)
ENSRROP00000034976Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (121 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (796 aa)
UBAP1Ubiquitin associated protein 1. (566 aa)
SHARPINSHANK associated RH domain interactor. (384 aa)
UCHL3Ubiquitin carboxyl-terminal hydrolase. (230 aa)
FBXW9F-box and WD repeat domain containing 9. (485 aa)
TNFAIP3TNF alpha induced protein 3. (790 aa)
OTUB1OTU deubiquitinase, ubiquitin aldehyde binding 1. (286 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (712 aa)
GGA2Golgi associated, gamma adaptin ear containing, ARF binding protein 2. (615 aa)
UBXN7UBX domain protein 7. (519 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (486 aa)
MARK4Non-specific serine/threonine protein kinase. (782 aa)
RNFT1Ring finger protein, transmembrane 1. (435 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1246 aa)
ENSRROP00000039709Uncharacterized protein. (304 aa)
CUEDC1CUE domain containing 1. (390 aa)
LOC104662867UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (112 aa)
UEVLDUEV and lactate/malate dehyrogenase domains. (470 aa)
VPS36Vacuolar protein sorting 36 homolog. (386 aa)
SPRTNSprT-like N-terminal domain. (488 aa)
HDAC6Histone deacetylase 6. (1258 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (571 aa)
USP5Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (858 aa)
BUB3WD_REPEATS_REGION domain-containing protein. (328 aa)
RAD23BRAD23 homolog B, nucleotide excision repair protein. (409 aa)
CUEDC2CUE domain containing 2. (287 aa)
RNF31Uncharacterized protein. (1072 aa)
AMFRAutocrine motility factor receptor. (643 aa)
USP13Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (863 aa)
FBXW7F-box and WD repeat domain containing 7. (707 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
Server load: low (16%) [HD]