STRINGSTRING
LOC104663113 LOC104663113 SHMT1 SHMT1 DHFR DHFR MDH1 MDH1 SLC46A1 SLC46A1 ENSRROP00000026108 ENSRROP00000026108 ENSRROP00000026864 ENSRROP00000026864 ENSRROP00000027231 ENSRROP00000027231 ENSRROP00000027491 ENSRROP00000027491 LOC104662045 LOC104662045 ALDH18A1 ALDH18A1 KMO KMO SDHA SDHA ENSRROP00000028963 ENSRROP00000028963 GLUD1 GLUD1 ENSRROP00000030966 ENSRROP00000030966 GCLC GCLC ENSRROP00000032048 ENSRROP00000032048 AASDHPPT AASDHPPT PCK1 PCK1 GOT2 GOT2 ENSRROP00000034780 ENSRROP00000034780 ADHFE1 ADHFE1 PHYH PHYH SDHB SDHB ENSRROP00000036750 ENSRROP00000036750 ENSRROP00000036753 ENSRROP00000036753 GLS GLS FOLR1 FOLR1 ALDH4A1 ALDH4A1 GPT2 GPT2 ACSF3 ACSF3 GCLM GCLM FPGS FPGS FH FH ENSRROP00000040164 ENSRROP00000040164 NIT2 NIT2 NAGS NAGS LOC104657056 LOC104657056 PRODH2 PRODH2 GAD1 GAD1 DGLUCY DGLUCY LOC104675180 LOC104675180 FTCD FTCD GOT1 GOT1 ALDH1L1 ALDH1L1 MTHFD1 MTHFD1 DLST DLST ACLY ACLY SHMT2 SHMT2 LIPF LIPF ENSRROP00000045302 ENSRROP00000045302 UROC1 UROC1 LOC104671997 LOC104671997 PCK2 PCK2 MDH1B MDH1B MTRR MTRR ENSRROP00000003271 ENSRROP00000003271 KYNU KYNU ASPA ASPA DHFR2 DHFR2 ASS1 ASS1 ENSRROP00000004722 ENSRROP00000004722 ENSRROP00000005654 ENSRROP00000005654 LOC104670790 LOC104670790 ALDH5A1 ALDH5A1 ENSRROP00000006531 ENSRROP00000006531 ENSRROP00000007048 ENSRROP00000007048 ENSRROP00000007257 ENSRROP00000007257 HAAO HAAO ACOT8 ACOT8 QPRT QPRT ENSRROP00000007768 ENSRROP00000007768 ENSRROP00000008157 ENSRROP00000008157 LOC104665044 LOC104665044 AMDHD1 AMDHD1 ENSRROP00000009222 ENSRROP00000009222 MTHFD2 MTHFD2 ME2 ME2 ME3 ME3 SDHAF3 SDHAF3 MTHFD1L MTHFD1L D2HGDH D2HGDH MDH2 MDH2 ENSRROP00000013258 ENSRROP00000013258 ENSRROP00000013527 ENSRROP00000013527 ST20-MTHFS ST20-MTHFS GRHPR GRHPR LOC104658281 LOC104658281 ENSRROP00000015266 ENSRROP00000015266 ENSRROP00000015323 ENSRROP00000015323 OAT OAT L2HGDH L2HGDH MTHFD2L MTHFD2L OGDH OGDH GLUD2 GLUD2 LOC104677180 LOC104677180 SLC19A1 SLC19A1 ENSRROP00000018274 ENSRROP00000018274 ME1 ME1 IDH1 IDH1 KYAT3 KYAT3 ENSRROP00000019132 ENSRROP00000019132 IDH2 IDH2 ALDH1L2 ALDH1L2 HAL HAL LOC104679638 LOC104679638 GOT1L1 GOT1L1 AADAT AADAT GLS2 GLS2 TAT TAT OGDHL OGDHL DDO DDO
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC104663113Uncharacterized protein. (392 aa)
SHMT1Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (483 aa)
DHFRDHFR domain-containing protein; Belongs to the dihydrofolate reductase family. (187 aa)
MDH1Malate dehydrogenase. (352 aa)
SLC46A1Solute carrier family 46 member 1. (459 aa)
ENSRROP00000026108Uncharacterized protein. (358 aa)
ENSRROP00000026864Aspartate aminotransferase. (389 aa)
ENSRROP00000027231THF_DHG_CYH_C domain-containing protein. (885 aa)
ENSRROP00000027491Uncharacterized protein. (94 aa)
LOC104662045Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (568 aa)
ALDH18A1Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. (795 aa)
KMOKynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. (477 aa)
SDHAUncharacterized protein. (557 aa)
ENSRROP00000028963Lyase_1 domain-containing protein. (196 aa)
GLUD1ELFV_dehydrog domain-containing protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (562 aa)
ENSRROP00000030966Uncharacterized protein. (103 aa)
GCLCGlutamate-cysteine ligase catalytic subunit. (637 aa)
ENSRROP00000032048Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (434 aa)
AASDHPPTAminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase. (309 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
GOT2Aspartate aminotransferase. (430 aa)
ENSRROP00000034780Uncharacterized protein. (97 aa)
ADHFE1Fe-ADH domain-containing protein. (467 aa)
PHYHPhytanoyl-CoA 2-hydroxylase. (338 aa)
SDHBSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (280 aa)
ENSRROP00000036750Uncharacterized protein. (190 aa)
ENSRROP00000036753ELFV_dehydrog domain-containing protein. (150 aa)
GLSGlutaminase. (669 aa)
FOLR1Folate receptor alpha. (257 aa)
ALDH4A1Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (563 aa)
GPT2Glutamic--pyruvic transaminase 2. (523 aa)
ACSF3Acyl-CoA synthetase family member 3. (576 aa)
GCLMGlutamate-cysteine ligase modifier subunit. (302 aa)
FPGSFolylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (588 aa)
FHFumarate hydratase. (510 aa)
ENSRROP00000040164Aminotran_1_2 domain-containing protein. (363 aa)
NIT2Nitrilase family member 2. (326 aa)
NAGSN-acetylglutamate synthase. (534 aa)
LOC104657056Uncharacterized protein. (451 aa)
PRODH2Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (484 aa)
GAD1Glutamate decarboxylase 1. (594 aa)
DGLUCYD-glutamate cyclase. (621 aa)
LOC104675180DHFR domain-containing protein; Belongs to the dihydrofolate reductase family. (180 aa)
FTCDFormimidoyltransferase cyclodeaminase. (530 aa)
GOT1Aspartate aminotransferase. (413 aa)
ALDH1L1Aldehyde dehydrogenase 1 family member L1; Belongs to the aldehyde dehydrogenase family. (937 aa)
MTHFD1Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1. (984 aa)
DLSTDihydrolipoamide S-succinyltransferase. (454 aa)
ACLYATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. (1148 aa)
SHMT2Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (506 aa)
LIPFLipase; Belongs to the AB hydrolase superfamily. Lipase family. (408 aa)
ENSRROP00000045302Uncharacterized protein. (112 aa)
UROC1Urocanate hydratase 1. (736 aa)
LOC104671997Malate dehydrogenase. (338 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (640 aa)
MDH1BUncharacterized protein. (517 aa)
MTRR5-methyltetrahydrofolate-homocysteine methyltransferase reductase. (698 aa)
ENSRROP00000003271SHMT domain-containing protein. (414 aa)
KYNUKynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. (465 aa)
ASPAAspartoacylase. (313 aa)
DHFR2Dihydrofolate reductase 2; Belongs to the dihydrofolate reductase family. (175 aa)
ASS1Uncharacterized protein. (412 aa)
ENSRROP00000004722Uncharacterized protein. (334 aa)
ENSRROP00000005654Uncharacterized protein. (103 aa)
LOC104670790DHFR domain-containing protein. (181 aa)
ALDH5A1Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (535 aa)
ENSRROP00000006531Uncharacterized protein. (411 aa)
ENSRROP00000007048Uncharacterized protein. (129 aa)
ENSRROP00000007257Uncharacterized protein. (66 aa)
HAAO3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family. (286 aa)
ACOT8Acyl-CoA thioesterase 8. (328 aa)
QPRTNicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (305 aa)
ENSRROP00000007768Uncharacterized protein. (371 aa)
ENSRROP00000008157Uncharacterized protein. (413 aa)
LOC104665044Uncharacterized protein. (455 aa)
AMDHD1Amidohydrolase domain containing 1. (426 aa)
ENSRROP00000009222DHFR domain-containing protein. (152 aa)
MTHFD2Uncharacterized protein. (350 aa)
ME2Malic enzyme. (584 aa)
ME3Malic enzyme. (604 aa)
SDHAF3Uncharacterized protein. (125 aa)
MTHFD1LMethylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (980 aa)
D2HGDHD-2-hydroxyglutarate dehydrogenase. (526 aa)
MDH2Malate dehydrogenase. (338 aa)
ENSRROP00000013258DHFR domain-containing protein; Belongs to the dihydrofolate reductase family. (170 aa)
ENSRROP00000013527Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (354 aa)
ST20-MTHFS5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (232 aa)
GRHPRGlyoxylate and hydroxypyruvate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (393 aa)
LOC104658281Uncharacterized protein. (580 aa)
ENSRROP00000015266Malate dehydrogenase. (282 aa)
ENSRROP00000015323DHFR domain-containing protein. (145 aa)
OATOrnithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (439 aa)
L2HGDHL-2-hydroxyglutarate dehydrogenase. (463 aa)
MTHFD2LMethylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like. (310 aa)
OGDHOxoglutarate dehydrogenase. (1038 aa)
GLUD2Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (537 aa)
LOC104677180Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (353 aa)
SLC19A1Solute carrier family 19 member 1. (586 aa)
ENSRROP00000018274CN hydrolase domain-containing protein. (92 aa)
ME1Malic enzyme. (572 aa)
IDH1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (414 aa)
KYAT3Kynurenine aminotransferase 3. (454 aa)
ENSRROP00000019132Uncharacterized protein. (340 aa)
IDH2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (449 aa)
ALDH1L210-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (923 aa)
HALHistidine ammonia-lyase; Belongs to the PAL/histidase family. (657 aa)
LOC104679638Glutamate decarboxylase 2. (305 aa)
GOT1L1Glutamic-oxaloacetic transaminase 1 like 1. (415 aa)
AADATAminoadipate aminotransferase. (425 aa)
GLS2Glutaminase 2. (602 aa)
TATTyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (454 aa)
OGDHLOxoglutarate dehydrogenase like. (1016 aa)
DDOD-aspartate oxidase. (369 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
Server load: low (20%) [HD]