STRINGSTRING
PAM PAM FOS FOS MMP2 MMP2 EPN1 EPN1 PSG9 PSG9 MED1 MED1 AVPR1A AVPR1A ABCC8 ABCC8 P2RX1 P2RX1 PMP22 PMP22 TAC1 TAC1 CSMD2 CSMD2 LAMB1 LAMB1 CITED2 CITED2 HMX3 HMX3 FUT7 FUT7 STS STS CORIN CORIN ADM ADM ITGB4 ITGB4 LIF LIF RGS2 RGS2 IGFBP2 IGFBP2 DSG1 DSG1 TGFB3 TGFB3 LDOC1 LDOC1 AKT1 AKT1 GHRL GHRL TGFBR2 TGFBR2 DDR1 DDR1 TACR1 TACR1 FOSB FOSB ACVR2A ACVR2A EPYC EPYC HPGD HPGD PTN PTN TLE6 TLE6 ADRA2B ADRA2B PRDM14 PRDM14 NPPA NPPA PPARD PPARD CRHBP CRHBP HAVCR2 HAVCR2 LNPEP LNPEP PRLR PRLR PCSK5 PCSK5 HSD11B2 HSD11B2 MST1 MST1 LOC104681458 LOC104681458 CRH CRH JUNB JUNB PRLHR PRLHR CLDN4 CLDN4 CYP27B1 CYP27B1 LOC104663618 LOC104663618 ASH1L ASH1L VMP1 VMP1 ACOD1 ACOD1 BMPR2 BMPR2 LOC104676314 LOC104676314 GIP GIP ENSRROP00000011040 ENSRROP00000011040 TEAD4 TEAD4 ATP7A ATP7A STAT5B STAT5B RECK RECK OXT OXT PTGFR PTGFR KLK14 KLK14 NR2F2 NR2F2 ITGA5 ITGA5 EPO EPO KALRN KALRN EMP2 EMP2 LOC104678360 LOC104678360 FOSL1 FOSL1 IDO1 IDO1 ANGPT2 ANGPT2 SOD1 SOD1 ITGA3 ITGA3 TAC3 TAC3 AGRP AGRP TEAD3 TEAD3 CLIC5 CLIC5 IHH IHH ADCYAP1 ADCYAP1 AMBP AMBP TGFB1 TGFB1 EPOR EPOR MAFF MAFF GNAS GNAS OXTR OXTR STC1 STC1 LOC104654344 LOC104654344 ITGA2 ITGA2 PLA2G4C PLA2G4C TMED2 TMED2 MAGED2 MAGED2 ADCY7 ADCY7 ENSRROP00000035956 ENSRROP00000035956 KLF1 KLF1 A1CF A1CF COL16A1 COL16A1 BCL2 BCL2 ENSRROP00000034704 ENSRROP00000034704 TRIM28 TRIM28 SERPINE2 SERPINE2 FBLN1 FBLN1 PTGS2 PTGS2 CSMD1 CSMD1 LOC104668178 LOC104668178 SLC38A3 SLC38A3 BSG BSG MMP9 MMP9 PRL PRL SLC19A1 SLC19A1 PRDM1 PRDM1 RARA RARA PAPPA PAPPA FKBP4 FKBP4 ENSRROP00000019944 ENSRROP00000019944 IGFBP5 IGFBP5 IGFBP7 IGFBP7 PGF PGF PNOC PNOC ARG1 ARG1 STOX2 STOX2 PLA2G6 PLA2G6 TCF23 TCF23 GHSR GHSR ITGB3 ITGB3 DDO DDO TRO TRO SPHK2 SPHK2 SP3 SP3 WNT4 WNT4 TPPP3 TPPP3 ACSL4 ACSL4 MEN1 MEN1 AR AR DEDD DEDD ENDOU ENDOU DAZAP1 DAZAP1 EDDM3B EDDM3B SLC2A1 SLC2A1 LOC104676315 LOC104676315 PLA2G4B PLA2G4B NODAL NODAL SPP1 SPP1 VDR VDR CALCA CALCA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PAMPeptidylglycine alpha-amidating monooxygenase. (975 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
MMP2Matrix metallopeptidase 2. (660 aa)
EPN1Epsin 1. (662 aa)
PSG9IGv domain-containing protein. (143 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1582 aa)
AVPR1AVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (421 aa)
ABCC8ATP binding cassette subfamily C member 8. (1585 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
PMP22Peripheral myelin protein 22; Might be involved in growth regulation, and in myelinization in the peripheral nervous system; Belongs to the PMP-22/EMP/MP20 family. (160 aa)
TAC1Tachykinin precursor 1. (129 aa)
CSMD2CUB and Sushi multiple domains 2. (3484 aa)
LAMB1Laminin subunit beta 1. (1836 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (275 aa)
HMX3H6 family homeobox 3. (318 aa)
FUT7Fucosyltransferase 7. (342 aa)
STSSteroid sulfatase. (590 aa)
CORINCorin, serine peptidase. (1021 aa)
ADMAdrenomedullin. (184 aa)
ITGB4Integrin beta. (1823 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
RGS2Regulator of G protein signaling 2. (211 aa)
IGFBP2Insulin like growth factor binding protein 2. (325 aa)
DSG1Desmoglein 1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1049 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
LDOC1LDOC1 regulator of NFKB signaling. (146 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
GHRLGhrelin and obestatin prepropeptide. (136 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
DDR1Discoidin domain receptor tyrosine kinase 1. (996 aa)
TACR1Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
EPYCEpiphycan. (322 aa)
HPGD15-hydroxyprostaglandin dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (266 aa)
PTNPleiotrophin. (167 aa)
TLE6TLE family member 6, subcortical maternal complex member. (572 aa)
ADRA2BAdrenoceptor alpha 2B. (448 aa)
PRDM14PR/SET domain 14. (580 aa)
NPPANatriuretic peptide A. (153 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
CRHBPCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (323 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (293 aa)
LNPEPLeucyl and cystinyl aminopeptidase. (1027 aa)
PRLRProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (619 aa)
PCSK5Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. (1786 aa)
HSD11B2Hydroxysteroid 11-beta dehydrogenase 2. (384 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. (752 aa)
LOC104681458DUF4939 domain-containing protein. (113 aa)
CRHCorticotropin releasing hormone. (196 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
PRLHRProlactin releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family. (370 aa)
CLDN4Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
CYP27B1Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
LOC104663618DUF4939 domain-containing protein. (113 aa)
ASH1LASH1 like histone lysine methyltransferase. (2916 aa)
VMP1Vacuole membrane protein 1. (406 aa)
ACOD1Aconitate decarboxylase 1. (480 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1002 aa)
LOC104676314Uncharacterized protein. (337 aa)
GIPGastric inhibitory polypeptide. (153 aa)
ENSRROP00000011040Uncharacterized protein. (409 aa)
TEAD4TEA domain transcription factor 4. (412 aa)
ATP7AUncharacterized protein. (475 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
RECKReversion inducing cysteine rich protein with kazal motifs. (958 aa)
OXTOxytocin/neurophysin I prepropeptide; Belongs to the vasopressin/oxytocin family. (125 aa)
PTGFRProstaglandin F receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
KLK14Kallikrein related peptidase 14; Belongs to the peptidase S1 family. (267 aa)
NR2F2Nuclear receptor subfamily 2 group F member 2. (414 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1098 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (192 aa)
KALRNKalirin RhoGEF kinase. (2980 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
LOC104678360Nuclear receptor domain-containing protein. (231 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (271 aa)
IDO1Indoleamine 2,3-dioxygenase 1. (402 aa)
ANGPT2Angiopoietin 2. (510 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (154 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1064 aa)
TAC3Tachykinin 3. (121 aa)
AGRPAgouti related neuropeptide. (132 aa)
TEAD3Transcriptional enhancer factor TEF-5; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (431 aa)
CLIC5Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (407 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
ADCYAP1Adenylate cyclase activating polypeptide 1. (176 aa)
AMBPAlpha-1-microglobulin/bikunin precursor. (352 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
EPORErythropoietin receptor; Receptor for erythropoietin. (508 aa)
MAFFMAF bZIP transcription factor F. (164 aa)
GNASGNAS complex locus. (1041 aa)
OXTROxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (389 aa)
STC1Stanniocalcin 1. (247 aa)
LOC104654344Uncharacterized protein. (354 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1151 aa)
PLA2G4CPhospholipase A2 group IVC. (551 aa)
TMED2Transmembrane p24 trafficking protein 2. (208 aa)
MAGED2MAGE family member D2. (606 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1095 aa)
ENSRROP00000035956Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (184 aa)
KLF1Kruppel like factor 1. (362 aa)
A1CFAPOBEC1 complementation factor. (592 aa)
COL16A1Collagen type XVI alpha 1 chain. (1604 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
ENSRROP00000034704GOLD domain-containing protein. (105 aa)
TRIM28Tripartite motif containing 28. (806 aa)
SERPINE2Serpin family E member 2; Belongs to the serpin family. (413 aa)
FBLN1Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (710 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
CSMD1CUB and Sushi multiple domains 1. (3281 aa)
LOC104668178Uncharacterized protein. (392 aa)
SLC38A3Solute carrier family 38 member 3. (520 aa)
BSGBasigin (Ok blood group). (362 aa)
MMP9Matrix metallopeptidase 9. (703 aa)
PRLProlactin. (228 aa)
SLC19A1Solute carrier family 19 member 1. (586 aa)
PRDM1PR/SET domain 1. (825 aa)
RARARetinoic acid receptor alpha. (478 aa)
PAPPAPappalysin 1. (1669 aa)
FKBP4Peptidylprolyl isomerase. (459 aa)
ENSRROP00000019944Uncharacterized protein. (291 aa)
IGFBP5Insulin like growth factor binding protein 5. (272 aa)
IGFBP7Insulin like growth factor binding protein 7. (282 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
PNOCPrepronociceptin. (176 aa)
ARG1Arginase. (322 aa)
STOX2Storkhead box 2. (925 aa)
PLA2G6Phospholipase A2 group VI. (806 aa)
TCF23Transcription factor 23. (214 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (788 aa)
DDOD-aspartate oxidase. (369 aa)
TROTrophinin. (1426 aa)
SPHK2Sphingosine kinase 2. (665 aa)
SP3Sp3 transcription factor. (735 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (345 aa)
TPPP3Tubulin polymerization promoting protein family member 3. (176 aa)
ACSL4Acyl-CoA synthetase long chain family member 4. (711 aa)
MEN1Menin 1. (610 aa)
ARUncharacterized protein. (523 aa)
DEDDDeath effector domain containing. (347 aa)
ENDOUEndonuclease, poly(U) specific. (411 aa)
DAZAP1DAZ associated protein 1. (418 aa)
EDDM3BEpididymal protein 3B. (147 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (506 aa)
LOC104676315Uncharacterized protein. (333 aa)
PLA2G4BPhospholipase A2. (798 aa)
NODALNodal growth differentiation factor. (347 aa)
SPP1Secreted phosphoprotein 1. (324 aa)
VDRVitamin D receptor. (477 aa)
CALCACalcitonin related polypeptide alpha. (140 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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