STRINGSTRING
TESC TESC LIF LIF HIF1A HIF1A HSF1 HSF1 ACIN1 ACIN1 ANKRD54 ANKRD54 SLC9B2 SLC9B2 ENSRROP00000003001 ENSRROP00000003001 KLF10 KLF10 RAB7B RAB7B GPR68 GPR68 ETS1 ETS1 ACVR2A ACVR2A ENSRROP00000004259 ENSRROP00000004259 ROR2 ROR2 CTNNBIP1 CTNNBIP1 NCKAP1L NCKAP1L ENSRROP00000006428 ENSRROP00000006428 HOXA5 HOXA5 CD4 CD4 TRIB1 TRIB1 TNFSF11 TNFSF11 PPARGC1B PPARGC1B POU4F1 POU4F1 INPP5D INPP5D STAT5B STAT5B CCR1 CCR1 CSF3 CSF3 CASP8 CASP8 SCIN SCIN JAG1 JAG1 DCSTAMP DCSTAMP PITHD1 PITHD1 CD101 CD101 POU4F2 POU4F2 LOC104665116 LOC104665116 LEF1 LEF1 ISG15 ISG15 TMEM64 TMEM64 STAT1 STAT1 IL17A IL17A ZFP36L1 ZFP36L1 ZNF16 ZNF16 FADD FADD FES FES LOC104663279 LOC104663279 RUNX1 RUNX1 LOC104663799 LOC104663799 HCLS1 HCLS1 TRAF6 TRAF6 GATA2 GATA2 TGFB1 TGFB1 IL23R IL23R MTURN MTURN PRKCA PRKCA THPO THPO MPL MPL HAX1 HAX1 SMAP1 SMAP1 PLA2G3 PLA2G3 IL20 IL20 PRKDC PRKDC IL23A IL23A PPP3CA PPP3CA PF4 PF4 TREM2 TREM2 ARNT ARNT BRD1 BRD1 IFNG IFNG FAXDC2 FAXDC2 STAT3 STAT3 RHEX RHEX RCOR1 RCOR1 ACVR1B ACVR1B CD74 CD74 IL34 IL34 INHBA INHBA CSF1 CSF1 GATA1 GATA1 RIPK1 RIPK1 CREB1 CREB1 ENSRROP00000023133 ENSRROP00000023133 RB1 RB1 KAT7 KAT7 KITLG KITLG ABCB10 ABCB10 FAM210B FAM210B MAPK14 MAPK14 OCSTAMP OCSTAMP LOC104659466 LOC104659466 NOTCH2 NOTCH2 NEDD9 NEDD9 NINJ1 NINJ1 CALCA CALCA FOS FOS MED1 MED1 TAL1 TAL1 PRMT1 PRMT1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TESCTescalcin. (214 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
HSF1Heat shock transcription factor 1. (557 aa)
ACIN1Apoptotic chromatin condensation inducer 1. (1341 aa)
ANKRD54Ankyrin repeat domain 54. (299 aa)
SLC9B2Solute carrier family 9 member B2. (537 aa)
ENSRROP00000003001Uncharacterized protein. (93 aa)
KLF10Kruppel like factor 10. (480 aa)
RAB7BRAB7B, member RAS oncogene family. (199 aa)
GPR68G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (375 aa)
ETS1ETS proto-oncogene 1, transcription factor. (485 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
ENSRROP00000004259TNF receptor-associated factor. (466 aa)
ROR2Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (942 aa)
CTNNBIP1Catenin beta interacting protein 1. (81 aa)
NCKAP1LNCK associated protein 1 like. (1134 aa)
ENSRROP00000006428Uncharacterized protein. (70 aa)
HOXA5Homeobox A5. (270 aa)
CD4CD4 molecule. (458 aa)
TRIB1Tribbles pseudokinase 1. (372 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (317 aa)
PPARGC1BPPARG coactivator 1 beta. (1024 aa)
POU4F1POU domain protein. (286 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1188 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
CCR1C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (367 aa)
CSF3Colony stimulating factor 3. (204 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (542 aa)
SCINScinderin. (715 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
DCSTAMPDendrocyte expressed seven transmembrane protein. (470 aa)
PITHD1PITH domain containing 1. (211 aa)
CD101CD101 molecule. (1021 aa)
POU4F2POU domain protein. (408 aa)
LOC104665116Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (255 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
ISG15ISG15 ubiquitin like modifier. (167 aa)
TMEM64Transmembrane protein 64. (326 aa)
STAT1Signal transducer and activator of transcription. (787 aa)
IL17AInterleukin 17A. (155 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
ZNF16Uncharacterized protein. (708 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
LOC104663279HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (254 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (482 aa)
LOC104663799Uncharacterized protein. (246 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (516 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
GATA2GATA binding protein 2. (480 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
IL23RInterleukin 23 receptor. (629 aa)
MTURNMaturin, neural progenitor differentiation regulator homolog. (111 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
THPOThrombopoietin. (353 aa)
MPLMPL proto-oncogene, thrombopoietin receptor. (635 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (279 aa)
SMAP1Small ArfGAP 1. (468 aa)
PLA2G3Phospholipase A2 group III. (506 aa)
IL20Interleukin 20. (176 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4159 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
PPP3CASerine/threonine-protein phosphatase. (417 aa)
PF4C-X-C motif chemokine. (101 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (844 aa)
BRD1Bromodomain containing 1. (1189 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
FAXDC2Fatty acid hydroxylase domain containing 2; Belongs to the sterol desaturase family. (333 aa)
STAT3Signal transducer and activator of transcription. (802 aa)
RHEXRegulator of hemoglobinization and erythroid cell expansion. (172 aa)
RCOR1REST corepressor 1. (486 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
CD74CD74 molecule. (294 aa)
IL34Interleukin 34. (242 aa)
INHBAInhibin subunit beta A. (492 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (555 aa)
GATA1GATA binding protein 1. (413 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
ENSRROP00000023133Uncharacterized protein. (235 aa)
RB1RB transcriptional corepressor 1. (929 aa)
KAT7Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (506 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
ABCB10ATP binding cassette subfamily B member 10. (738 aa)
FAM210BFamily with sequence similarity 210 member B. (192 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
OCSTAMPOsteoclast stimulatory transmembrane protein. (552 aa)
LOC104659466Uncharacterized protein. (682 aa)
NOTCH2Notch receptor 2. (2471 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (834 aa)
NINJ1Ninjurin 1. (152 aa)
CALCACalcitonin related polypeptide alpha. (140 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1582 aa)
TAL1TAL bHLH transcription factor 1, erythroid differentiation factor. (286 aa)
PRMT1Methyltransf_25 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (371 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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