STRINGSTRING
ATF2 ATF2 ITGAX ITGAX ADGRB1 ADGRB1 SERPINE1 SERPINE1 APELA APELA HGF HGF ALOX5 ALOX5 GATA6 GATA6 PDCD10 PDCD10 FOXC2 FOXC2 FKBPL FKBPL LOC104655302 LOC104655302 TLR3 TLR3 TBC1D31 TBC1D31 SFRP2 SFRP2 COL4A3 COL4A3 DDAH1 DDAH1 HIPK1 HIPK1 ATP2B4 ATP2B4 EGLN1 EGLN1 SYNJ2BP SYNJ2BP IL17F IL17F GHRL GHRL PDPK1 PDPK1 CD34 CD34 CXCL10 CXCL10 SERPINF1 SERPINF1 TGFBR2 TGFBR2 EPN2 EPN2 GRN GRN GDF2 GDF2 ERAP1 ERAP1 ETS1 ETS1 PML PML ANGPTL3 ANGPTL3 ENSRROP00000004791 ENSRROP00000004791 RRAS RRAS GPR4 GPR4 WARS1 WARS1 KRIT1 KRIT1 ENPP2 ENPP2 LOC104657906 LOC104657906 CCM2 CCM2 AGO2 AGO2 CYSLTR1 CYSLTR1 ITGB8 ITGB8 DAB2IP DAB2IP PLXND1 PLXND1 RNH1 RNH1 HIF1A HIF1A AQP1 AQP1 SIRT6 SIRT6 VEGFB VEGFB ENSRROP00000000053 ENSRROP00000000053 ITGA5 ITGA5 ENSRROP00000045221 ENSRROP00000045221 NFE2L2 NFE2L2 CXCL8 CXCL8 SEMA6A SEMA6A EMP2 EMP2 ERBB2 ERBB2 CDH5 CDH5 PIK3CB PIK3CB MECP2 MECP2 NR2E1 NR2E1 THBS1 THBS1 IL10 IL10 AGO1 AGO1 ITGB2 ITGB2 C3 C3 ANGPT2 ANGPT2 PRKCA PRKCA NF1 NF1 RAMP2 RAMP2 TBXA2R TBXA2R FGF18 FGF18 GATA4 GATA4 CCL24 CCL24 FLT1 FLT1 ECSCR ECSCR VEGFA VEGFA EFNA1 EFNA1 HSPB6 HSPB6 MAPK7 MAPK7 ROCK1 ROCK1 ENSRROP00000040954 ENSRROP00000040954 PPP1R15A PPP1R15A RLN2 RLN2 JAK1 JAK1 PTGIS PTGIS HHEX HHEX SEMA4A SEMA4A EMILIN2 EMILIN2 GPNMB GPNMB GATA2 GATA2 ZNF304 ZNF304 PTK2B PTK2B CXCL13 CXCL13 ADM2 ADM2 GLUL GLUL SMAD1 SMAD1 RUNX1 RUNX1 FGF2 FGF2 SFRP1 SFRP1 HMOX1 HMOX1 LOC104680991 LOC104680991 ENSRROP00000036642 ENSRROP00000036642 CREB3L1 CREB3L1 LRG1 LRG1 THBS4 THBS4 ADAMTS1 ADAMTS1 FASLG FASLG MYDGF MYDGF ENSRROP00000035956 ENSRROP00000035956 ANGPT4 ANGPT4 HGS HGS VASH2 VASH2 IL1B IL1B TIE1 TIE1 TNFSF12 TNFSF12 PAK4 PAK4 APOH APOH STAT1 STAT1 YJEFN3 YJEFN3 BRCA1 BRCA1 ADM ADM TGFB2 TGFB2 MDK MDK AMOT AMOT HSPB1 HSPB1 TMIGD2 TMIGD2 CNMD CNMD ADGRB3 ADGRB3 KLF4 KLF4 ENSRROP00000031184 ENSRROP00000031184 HSPG2 HSPG2 HTATIP2 HTATIP2 ABCC8 ABCC8 CTNNB1 CTNNB1 PKM PKM THBS2 THBS2 CX3CR1 CX3CR1 EPN1 EPN1 COL4A2 COL4A2 LOC104682820 LOC104682820 ADGRB2 ADGRB2 ADAMTS9 ADAMTS9 NINJ1 NINJ1 NODAL NODAL TJP1 TJP1 SARS1 SARS1 CXCR3 CXCR3 PTPRM PTPRM C5 C5 KLF2 KLF2 LOC104669094 LOC104669094 TNMD TNMD ZC3H12A ZC3H12A SPRED1 SPRED1 TNN TNN SMOC2 SMOC2 NRP1 NRP1 CD40 CD40 SEMA5A SEMA5A PPP1R16B PPP1R16B PLCG1 PLCG1 KDR KDR F3 F3 RTN4 RTN4 APLNR APLNR ENSRROP00000007515 ENSRROP00000007515 CTSH CTSH HOXA5 HOXA5 RHOB RHOB LOC104679892 LOC104679892 SEMA3E SEMA3E ENSRROP00000024190 ENSRROP00000024190 FOXO4 FOXO4 JUP JUP ITGB3 ITGB3 GHSR GHSR XBP1 XBP1 SPINK5 SPINK5 ROCK2 ROCK2 NIBAN2 NIBAN2 PRKD2 PRKD2 BTG1 BTG1 HPSE HPSE OR10J5 OR10J5 C5AR1 C5AR1 AKT3 AKT3 NOS3 NOS3 SIRT1 SIRT1 GTF2I GTF2I PRKCB PRKCB PROK1 PROK1 STIM1 STIM1 PGF PGF VASH1 VASH1 CLDN5 CLDN5 CHRNA7 CHRNA7 FGF1 FGF1 CCR3 CCR3 ADAM12 ADAM12 CHI3L1 CHI3L1 CD160 CD160 DCN DCN NPR1 NPR1 SPARC SPARC STAT3 STAT3 LEP LEP HRG HRG SLC12A2 SLC12A2 WARS2 WARS2 ACVRL1 ACVRL1 NPPB NPPB EMC10 EMC10 CYP1B1 CYP1B1 JMJD8 JMJD8 TERT TERT MTDH MTDH RHOJ RHOJ GADD45A GADD45A ISM1 ISM1 HMGA2 HMGA2 SPRY2 SPRY2 ABL1 ABL1 STAB1 STAB1 FOXJ2 FOXJ2 PF4 PF4 WNT5A WNT5A NAXE NAXE MINAR1 MINAR1 SP100 SP100 CEACAM1 CEACAM1 SPHK1 SPHK1 CYBB CYBB RAPGEF3 RAPGEF3 SULF1 SULF1 ANXA3 ANXA3 BMPER BMPER PRKD1 PRKD1 HYAL1 HYAL1 HK2 HK2 TSPAN12 TSPAN12 PDE3B PDE3B CELA1 CELA1 NTRK1 NTRK1 PLK2 PLK2 RECK RECK PIK3CD PIK3CD DLL1 DLL1 ADGRA2 ADGRA2 CCBE1 CCBE1 EPHA1 EPHA1 ECM1 ECM1 GAB1 GAB1 PIK3R6 PIK3R6 JCAD JCAD ENG ENG SASH1 SASH1 RGCC RGCC EPHA2 EPHA2 VEGFD VEGFD ANGPTL4 ANGPTL4 VEGFC VEGFC E2F2 E2F2 SP1 SP1 HIPK2 HIPK2 EMILIN1 EMILIN1 ISL1 ISL1 TEK TEK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ITGAXIntegrin subunit alpha X; Belongs to the integrin alpha chain family. (1154 aa)
ADGRB1Adhesion G protein-coupled receptor B1; Belongs to the G-protein coupled receptor 2 family. (1508 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (444 aa)
APELAApelin receptor early endogenous ligand. (54 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
ALOX5Arachidonate 5-lipoxygenase. (646 aa)
GATA6GATA binding protein 6. (548 aa)
PDCD10Uncharacterized protein. (212 aa)
FOXC2Forkhead box C2. (501 aa)
FKBPLFKBP prolyl isomerase like. (349 aa)
LOC104655302SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (205 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
TBC1D31Uncharacterized protein. (1067 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
COL4A3Collagen type IV alpha 3 chain. (1670 aa)
DDAH1Dimethylarginine dimethylaminohydrolase 1. (285 aa)
HIPK1Homeodomain interacting protein kinase 1. (1210 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1205 aa)
EGLN1Fe2OG dioxygenase domain-containing protein. (128 aa)
SYNJ2BPSynaptojanin 2 binding protein. (145 aa)
IL17FInterleukin 17F. (163 aa)
GHRLGhrelin and obestatin prepropeptide. (136 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (356 aa)
CD34CD34 molecule. (385 aa)
CXCL10C-X-C motif chemokine. (98 aa)
SERPINF1Serpin family F member 1; Belongs to the serpin family. (418 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
EPN2Epsin 2. (641 aa)
GRNGranulin precursor. (593 aa)
GDF2Growth differentiation factor 2. (429 aa)
ERAP1Aminopeptidase. (941 aa)
ETS1ETS proto-oncogene 1, transcription factor. (485 aa)
PMLPromyelocytic leukemia. (882 aa)
ANGPTL3Angiopoietin like 3. (460 aa)
ENSRROP00000004791Uncharacterized protein. (65 aa)
RRASRAS related. (218 aa)
GPR4G protein-coupled receptor 4; Belongs to the G-protein coupled receptor 1 family. (362 aa)
WARS1Tryptophanyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (475 aa)
KRIT1Uncharacterized protein. (736 aa)
ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase 2. (940 aa)
LOC104657906NAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. (288 aa)
CCM2CCM2 scaffold protein. (466 aa)
AGO2Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (865 aa)
CYSLTR1Cysteinyl leukotriene receptor 1. (337 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (769 aa)
DAB2IPDAB2 interacting protein. (1189 aa)
PLXND1Plexin D1. (1863 aa)
RNH1Ribonuclease/angiogenin inhibitor 1. (548 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
AQP1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa)
SIRT6Sirtuin 6. (355 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
ENSRROP00000000053Pyruvate kinase; Belongs to the pyruvate kinase family. (542 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1098 aa)
ENSRROP00000045221Uncharacterized protein. (200 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (606 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (1047 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
ERBB2Receptor protein-tyrosine kinase. (1352 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (784 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (498 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (421 aa)
THBS1Thrombospondin 1. (1170 aa)
IL10Interleukin 10. (178 aa)
AGO1Argonaute RISC component 1; Belongs to the argonaute family. (857 aa)
ITGB2Integrin beta. (769 aa)
C3Complement C3. (1663 aa)
ANGPT2Angiopoietin 2. (510 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
NF1Neurofibromin 1. (2821 aa)
RAMP2Receptor activity modifying protein 2. (175 aa)
TBXA2RThromboxane A2 receptor. (384 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
GATA4GATA binding protein 4. (417 aa)
CCL24C-C motif chemokine ligand 24. (111 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1337 aa)
ECSCRUncharacterized protein. (205 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (205 aa)
HSPB6Heat shock protein family B (small) member 6; Belongs to the small heat shock protein (HSP20) family. (189 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
ENSRROP00000040954Gln-synt_C domain-containing protein; Belongs to the glutamine synthetase family. (347 aa)
PPP1R15AProtein phosphatase 1 regulatory subunit 15A. (692 aa)
RLN2Relaxin 2. (185 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
PTGISProstacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. (500 aa)
HHEXHematopoietically expressed homeobox. (266 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (778 aa)
EMILIN2Elastin microfibril interfacer 2. (982 aa)
GPNMBGlycoprotein nmb. (561 aa)
GATA2GATA binding protein 2. (480 aa)
ZNF304Zinc finger protein 304. (707 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1058 aa)
CXCL13C-X-C motif chemokine. (109 aa)
ADM2Adrenomedullin 2. (148 aa)
GLULGlutamine synthetase. (373 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (482 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (263 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
HMOX1Heme oxygenase 1. (303 aa)
LOC104680991Uncharacterized protein. (173 aa)
ENSRROP00000036642Phorbol-ester/DAG-type domain-containing protein. (57 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (347 aa)
THBS4Thrombospondin 4. (961 aa)
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif 1. (967 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (280 aa)
MYDGFMyeloid derived growth factor. (174 aa)
ENSRROP00000035956Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (184 aa)
ANGPT4Angiopoietin 4. (503 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (796 aa)
VASH2Vasohibin 2. (355 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1138 aa)
TNFSF12TNF superfamily member 12; Belongs to the tumor necrosis factor family. (249 aa)
PAK4Non-specific serine/threonine protein kinase. (655 aa)
APOHApolipoprotein H. (345 aa)
STAT1Signal transducer and activator of transcription. (787 aa)
YJEFN3YjeF N-terminal domain containing 3. (293 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1836 aa)
ADMAdrenomedullin. (184 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
MDKUncharacterized protein. (143 aa)
AMOTAngiomotin. (1086 aa)
HSPB1SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (205 aa)
TMIGD2Transmembrane and immunoglobulin domain containing 2. (275 aa)
CNMDChondromodulin. (334 aa)
ADGRB3Adhesion G protein-coupled receptor B3; Belongs to the G-protein coupled receptor 2 family. (1522 aa)
KLF4Kruppel like factor 4. (479 aa)
ENSRROP00000031184Fork-head domain-containing protein. (193 aa)
HSPG2Heparan sulfate proteoglycan 2. (4391 aa)
HTATIP2HIV-1 Tat interactive protein 2. (277 aa)
ABCC8ATP binding cassette subfamily C member 8. (1585 aa)
CTNNB1Catenin beta 1. (781 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (556 aa)
THBS2Thrombospondin 2. (1172 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (375 aa)
EPN1Epsin 1. (662 aa)
COL4A2Collagen type IV alpha 2 chain. (1712 aa)
LOC104682820Uncharacterized protein. (143 aa)
ADGRB2Adhesion G protein-coupled receptor B2; Belongs to the G-protein coupled receptor 2 family. (1587 aa)
ADAMTS9ADAM metallopeptidase with thrombospondin type 1 motif 9. (1935 aa)
NINJ1Ninjurin 1. (152 aa)
NODALNodal growth differentiation factor. (347 aa)
TJP1Tight junction protein 1; Belongs to the MAGUK family. (1756 aa)
SARS1Seryl-tRNA synthetase. (536 aa)
CXCR3C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (368 aa)
PTPRMProtein tyrosine phosphatase receptor type M. (1407 aa)
C5Complement C5. (950 aa)
KLF2Uncharacterized protein. (115 aa)
LOC104669094Pyruvate kinase; Belongs to the pyruvate kinase family. (448 aa)
TNMDTenomodulin. (317 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (601 aa)
SPRED1Sprouty related EVH1 domain containing 1. (444 aa)
TNNTenascin N. (1299 aa)
SMOC2SPARC related modular calcium binding 2. (457 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
CD40CD40 molecule. (278 aa)
SEMA5ASemaphorin 5A. (1056 aa)
PPP1R16BProtein phosphatase 1 regulatory subunit 16B. (567 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1303 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
F3Coagulation factor III, tissue factor. (296 aa)
RTN4Reticulon. (1138 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
ENSRROP00000007515Gln-synt_C domain-containing protein; Belongs to the glutamine synthetase family. (351 aa)
CTSHCathepsin H; Belongs to the peptidase C1 family. (335 aa)
HOXA5Homeobox A5. (270 aa)
RHOBRas homolog family member B. (196 aa)
LOC104679892BRCT domain-containing protein. (96 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (775 aa)
ENSRROP00000024190Protein kinase domain-containing protein. (137 aa)
FOXO4Forkhead box O4. (505 aa)
JUPJunction plakoglobin. (760 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (788 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
XBP1BZIP domain-containing protein. (380 aa)
SPINK5Serine peptidase inhibitor, Kazal type 5. (1087 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1383 aa)
NIBAN2Niban apoptosis regulator 2. (746 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
BTG1BTG anti-proliferation factor 1. (171 aa)
HPSEHeparanase. (545 aa)
OR10J5Olfactory receptor family 10 subfamily J member 5. (226 aa)
C5AR1Complement C5a receptor 1; Belongs to the G-protein coupled receptor 1 family. (350 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
SIRT1Sirtuin 1. (746 aa)
GTF2IGeneral transcription factor IIi. (998 aa)
PRKCBNon-specific serine/threonine protein kinase. (590 aa)
PROK1Prokineticin 1. (105 aa)
STIM1Stromal interaction molecule 1. (785 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
VASH1Vasohibin 1. (365 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (279 aa)
CHRNA7Uncharacterized protein. (531 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
CCR3C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (376 aa)
ADAM12ADAM metallopeptidase domain 12. (909 aa)
CHI3L1Chitinase 3 like 1; Belongs to the glycosyl hydrolase 18 family. (405 aa)
CD160CD160 molecule. (232 aa)
DCNDecorin; May affect the rate of fibrils formation. (359 aa)
NPR1Guanylate cyclase. (1284 aa)
SPARCSecreted protein acidic and cysteine rich. (341 aa)
STAT3Signal transducer and activator of transcription. (802 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
HRGHistidine rich glycoprotein. (526 aa)
SLC12A2Solute carrier family 12 member 2. (1210 aa)
WARS2Tryptophanyl tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. (244 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
NPPBNatriuretic peptide B. (134 aa)
EMC10ER membrane protein complex subunit 10. (346 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (543 aa)
JMJD8Jumonji domain containing 8. (285 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1132 aa)
MTDHMetadherin. (582 aa)
RHOJRas homolog family member J. (214 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
ISM1Isthmin 1. (464 aa)
HMGA2High mobility group AT-hook 2. (147 aa)
SPRY2Sprouty RTK signaling antagonist 2. (338 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
STAB1Stabilin 1. (2568 aa)
FOXJ2Forkhead box J2. (574 aa)
PF4C-X-C motif chemokine. (101 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
NAXENAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. (288 aa)
MINAR1Membrane integral NOTCH2 associated receptor 1. (916 aa)
SP100SP100 nuclear antigen. (797 aa)
CEACAM1Uncharacterized protein. (525 aa)
SPHK1Sphingosine kinase 1. (472 aa)
CYBBCytochrome b-245 beta chain. (570 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (923 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (869 aa)
ANXA3Annexin. (323 aa)
BMPERBMP binding endothelial regulator. (685 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (895 aa)
HYAL1Hyaluronidase. (435 aa)
HK2Hexokinase 2. (917 aa)
TSPAN12Tetraspanin. (305 aa)
PDE3BPhosphodiesterase. (1113 aa)
CELA1Chymotrypsin like elastase 1; Belongs to the peptidase S1 family. (225 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
RECKReversion inducing cysteine rich protein with kazal motifs. (958 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (748 aa)
ADGRA2Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1284 aa)
CCBE1Collagen and calcium binding EGF domains 1. (428 aa)
EPHA1EPH receptor A1. (976 aa)
ECM1Extracellular matrix protein 1. (540 aa)
GAB1GRB2 associated binding protein 1. (724 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (464 aa)
JCADJunctional cadherin 5 associated. (1357 aa)
ENGEndoglin. (658 aa)
SASH1SAM and SH3 domain containing 1. (1230 aa)
RGCCRegulator of cell cycle. (134 aa)
EPHA2EPH receptor A2. (1033 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
ANGPTL4Angiopoietin like 4. (406 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
E2F2E2F transcription factor 2. (437 aa)
SP1Sp1 transcription factor. (786 aa)
HIPK2Homeodomain interacting protein kinase 2. (1197 aa)
EMILIN1Elastin microfibril interfacer 1. (1016 aa)
ISL1ISL LIM homeobox 1. (349 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
Server load: medium (56%) [HD]