STRINGSTRING
FGF18 FGF18 GATA4 GATA4 CCL24 CCL24 FLT1 FLT1 VEGFA VEGFA HSPB6 HSPB6 RLN2 RLN2 JAK1 JAK1 PTGIS PTGIS EMILIN2 EMILIN2 GATA2 GATA2 ZNF304 ZNF304 PTK2B PTK2B ADM2 ADM2 SMAD1 SMAD1 RUNX1 RUNX1 FGF2 FGF2 HMOX1 HMOX1 LOC104680991 LOC104680991 ENSRROP00000036642 ENSRROP00000036642 LRG1 LRG1 MYDGF MYDGF ENSRROP00000035956 ENSRROP00000035956 ANGPT4 ANGPT4 VASH2 VASH2 IL1B IL1B TIE1 TIE1 TNFSF12 TNFSF12 PAK4 PAK4 BRCA1 BRCA1 ADM ADM MDK MDK HSPB1 HSPB1 TMIGD2 TMIGD2 KLF4 KLF4 PKM PKM CX3CR1 CX3CR1 LOC104682820 LOC104682820 NINJ1 NINJ1 NODAL NODAL TJP1 TJP1 CXCR3 CXCR3 C5 C5 LOC104669094 LOC104669094 ZC3H12A ZC3H12A TNN TNN SMOC2 SMOC2 NRP1 NRP1 CD40 CD40 SEMA5A SEMA5A PLCG1 PLCG1 KDR KDR LOC104679892 LOC104679892 ENSRROP00000024190 ENSRROP00000024190 JUP JUP ITGB3 ITGB3 GHSR GHSR XBP1 XBP1 PRKD2 PRKD2 BTG1 BTG1 HPSE HPSE C5AR1 C5AR1 AKT3 AKT3 NOS3 NOS3 SIRT1 SIRT1 PRKCB PRKCB STIM1 STIM1 PGF PGF CHRNA7 CHRNA7 FGF1 FGF1 CCR3 CCR3 ADAM12 ADAM12 CHI3L1 CHI3L1 STAT3 STAT3 WARS2 WARS2 ACVRL1 ACVRL1 EMC10 EMC10 JMJD8 JMJD8 TERT TERT MTDH MTDH HMGA2 HMGA2 ABL1 ABL1 WNT5A WNT5A SPHK1 SPHK1 CYBB CYBB RAPGEF3 RAPGEF3 ANXA3 ANXA3 BMPER BMPER PRKD1 PRKD1 HYAL1 HYAL1 HK2 HK2 CELA1 CELA1 NTRK1 NTRK1 PIK3CD PIK3CD DLL1 DLL1 CCBE1 CCBE1 EPHA1 EPHA1 ECM1 ECM1 GAB1 GAB1 PIK3R6 PIK3R6 JCAD JCAD ENG ENG SASH1 SASH1 VEGFD VEGFD ANGPTL4 ANGPTL4 VEGFC VEGFC SP1 SP1 HIPK2 HIPK2 EMILIN1 EMILIN1 ISL1 ISL1 TEK TEK ITGAX ITGAX SERPINE1 SERPINE1 APELA APELA HGF HGF F3 F3 CYP1B1 CYP1B1 RHOB RHOB CTSH CTSH APLNR APLNR RTN4 RTN4 RRAS RRAS ENSRROP00000004791 ENSRROP00000004791 ANGPTL3 ANGPTL3 ETS1 ETS1 ERAP1 ERAP1 GDF2 GDF2 GRN GRN TGFBR2 TGFBR2 CD34 CD34 PDPK1 PDPK1 GHRL GHRL HIPK1 HIPK1 DDAH1 DDAH1 SFRP2 SFRP2 TLR3 TLR3 LOC104655302 LOC104655302 FOXC2 FOXC2 GATA6 GATA6 AGO2 AGO2 CYSLTR1 CYSLTR1 ITGB8 ITGB8 HIF1A HIF1A AQP1 AQP1 SIRT6 SIRT6 VEGFB VEGFB ENSRROP00000000053 ENSRROP00000000053 TBXA2R TBXA2R RAMP2 RAMP2 PRKCA PRKCA ANGPT2 ANGPT2 C3 C3 ITGB2 ITGB2 IL10 IL10 THBS1 THBS1 NR2E1 NR2E1 CDH5 CDH5 EMP2 EMP2 CXCL8 CXCL8 NFE2L2 NFE2L2 ITGA5 ITGA5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
GATA4GATA binding protein 4. (417 aa)
CCL24C-C motif chemokine ligand 24. (111 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1337 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
HSPB6Heat shock protein family B (small) member 6; Belongs to the small heat shock protein (HSP20) family. (189 aa)
RLN2Relaxin 2. (185 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
PTGISProstacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. (500 aa)
EMILIN2Elastin microfibril interfacer 2. (982 aa)
GATA2GATA binding protein 2. (480 aa)
ZNF304Zinc finger protein 304. (707 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1058 aa)
ADM2Adrenomedullin 2. (148 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (482 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (263 aa)
HMOX1Heme oxygenase 1. (303 aa)
LOC104680991Uncharacterized protein. (173 aa)
ENSRROP00000036642Phorbol-ester/DAG-type domain-containing protein. (57 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (347 aa)
MYDGFMyeloid derived growth factor. (174 aa)
ENSRROP00000035956Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (184 aa)
ANGPT4Angiopoietin 4. (503 aa)
VASH2Vasohibin 2. (355 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1138 aa)
TNFSF12TNF superfamily member 12; Belongs to the tumor necrosis factor family. (249 aa)
PAK4Non-specific serine/threonine protein kinase. (655 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1836 aa)
ADMAdrenomedullin. (184 aa)
MDKUncharacterized protein. (143 aa)
HSPB1SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (205 aa)
TMIGD2Transmembrane and immunoglobulin domain containing 2. (275 aa)
KLF4Kruppel like factor 4. (479 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (556 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (375 aa)
LOC104682820Uncharacterized protein. (143 aa)
NINJ1Ninjurin 1. (152 aa)
NODALNodal growth differentiation factor. (347 aa)
TJP1Tight junction protein 1; Belongs to the MAGUK family. (1756 aa)
CXCR3C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (368 aa)
C5Complement C5. (950 aa)
LOC104669094Pyruvate kinase; Belongs to the pyruvate kinase family. (448 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (601 aa)
TNNTenascin N. (1299 aa)
SMOC2SPARC related modular calcium binding 2. (457 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
CD40CD40 molecule. (278 aa)
SEMA5ASemaphorin 5A. (1056 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1303 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
LOC104679892BRCT domain-containing protein. (96 aa)
ENSRROP00000024190Protein kinase domain-containing protein. (137 aa)
JUPJunction plakoglobin. (760 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (788 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
XBP1BZIP domain-containing protein. (380 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
BTG1BTG anti-proliferation factor 1. (171 aa)
HPSEHeparanase. (545 aa)
C5AR1Complement C5a receptor 1; Belongs to the G-protein coupled receptor 1 family. (350 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
SIRT1Sirtuin 1. (746 aa)
PRKCBNon-specific serine/threonine protein kinase. (590 aa)
STIM1Stromal interaction molecule 1. (785 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
CHRNA7Uncharacterized protein. (531 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
CCR3C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (376 aa)
ADAM12ADAM metallopeptidase domain 12. (909 aa)
CHI3L1Chitinase 3 like 1; Belongs to the glycosyl hydrolase 18 family. (405 aa)
STAT3Signal transducer and activator of transcription. (802 aa)
WARS2Tryptophanyl tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. (244 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
EMC10ER membrane protein complex subunit 10. (346 aa)
JMJD8Jumonji domain containing 8. (285 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1132 aa)
MTDHMetadherin. (582 aa)
HMGA2High mobility group AT-hook 2. (147 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
SPHK1Sphingosine kinase 1. (472 aa)
CYBBCytochrome b-245 beta chain. (570 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (923 aa)
ANXA3Annexin. (323 aa)
BMPERBMP binding endothelial regulator. (685 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (895 aa)
HYAL1Hyaluronidase. (435 aa)
HK2Hexokinase 2. (917 aa)
CELA1Chymotrypsin like elastase 1; Belongs to the peptidase S1 family. (225 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (748 aa)
CCBE1Collagen and calcium binding EGF domains 1. (428 aa)
EPHA1EPH receptor A1. (976 aa)
ECM1Extracellular matrix protein 1. (540 aa)
GAB1GRB2 associated binding protein 1. (724 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (464 aa)
JCADJunctional cadherin 5 associated. (1357 aa)
ENGEndoglin. (658 aa)
SASH1SAM and SH3 domain containing 1. (1230 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
ANGPTL4Angiopoietin like 4. (406 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
SP1Sp1 transcription factor. (786 aa)
HIPK2Homeodomain interacting protein kinase 2. (1197 aa)
EMILIN1Elastin microfibril interfacer 1. (1016 aa)
ISL1ISL LIM homeobox 1. (349 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
ITGAXIntegrin subunit alpha X; Belongs to the integrin alpha chain family. (1154 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (444 aa)
APELAApelin receptor early endogenous ligand. (54 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
F3Coagulation factor III, tissue factor. (296 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (543 aa)
RHOBRas homolog family member B. (196 aa)
CTSHCathepsin H; Belongs to the peptidase C1 family. (335 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
RTN4Reticulon. (1138 aa)
RRASRAS related. (218 aa)
ENSRROP00000004791Uncharacterized protein. (65 aa)
ANGPTL3Angiopoietin like 3. (460 aa)
ETS1ETS proto-oncogene 1, transcription factor. (485 aa)
ERAP1Aminopeptidase. (941 aa)
GDF2Growth differentiation factor 2. (429 aa)
GRNGranulin precursor. (593 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
CD34CD34 molecule. (385 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (356 aa)
GHRLGhrelin and obestatin prepropeptide. (136 aa)
HIPK1Homeodomain interacting protein kinase 1. (1210 aa)
DDAH1Dimethylarginine dimethylaminohydrolase 1. (285 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
LOC104655302SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (205 aa)
FOXC2Forkhead box C2. (501 aa)
GATA6GATA binding protein 6. (548 aa)
AGO2Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (865 aa)
CYSLTR1Cysteinyl leukotriene receptor 1. (337 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (769 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
AQP1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa)
SIRT6Sirtuin 6. (355 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
ENSRROP00000000053Pyruvate kinase; Belongs to the pyruvate kinase family. (542 aa)
TBXA2RThromboxane A2 receptor. (384 aa)
RAMP2Receptor activity modifying protein 2. (175 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
ANGPT2Angiopoietin 2. (510 aa)
C3Complement C3. (1663 aa)
ITGB2Integrin beta. (769 aa)
IL10Interleukin 10. (178 aa)
THBS1Thrombospondin 1. (1170 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (421 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (784 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (606 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1098 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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