STRINGSTRING
CAV1 CAV1 SH2B3 SH2B3 ENSRROP00000011896 ENSRROP00000011896 ENSRROP00000007022 ENSRROP00000007022 PTPN2 PTPN2 VHL VHL SOCS1 SOCS1 NEUROD1 NEUROD1 NF2 NF2 SOCS3 SOCS3 SOCS2 SOCS2 GGNBP2 GGNBP2 BCL3 BCL3 LEPROT LEPROT PARP14 PARP14 HGS HGS PIBF1 PIBF1 PPP2R1A PPP2R1A INPP5F INPP5F ENSRROP00000026852 ENSRROP00000026852 PTPRD PTPRD PPP2CA PPP2CA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (147 aa)
SH2B3SH2B adaptor protein 3. (596 aa)
ENSRROP00000011896Tyrosine-protein phosphatase non-receptor type. (354 aa)
ENSRROP00000007022Uncharacterized protein. (110 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (415 aa)
VHLVon Hippel-Lindau tumor suppressor. (213 aa)
SOCS1Suppressor of cytokine signaling 1. (215 aa)
NEUROD1Neurogenic differentiation factor. (356 aa)
NF2Neurofibromin 2. (595 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
GGNBP2Gametogenetin binding protein 2. (739 aa)
BCL3BCL3 transcription coactivator. (454 aa)
LEPROTLeptin receptor overlapping transcript. (139 aa)
PARP14Poly [ADP-ribose] polymerase. (1800 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (796 aa)
PIBF1Progesterone immunomodulatory binding factor 1. (757 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
INPP5FInositol polyphosphate-5-phosphatase F. (1132 aa)
ENSRROP00000026852Uncharacterized protein. (321 aa)
PTPRDProtein tyrosine phosphatase receptor type D. (1793 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
Server load: low (18%) [HD]