(34 nodes) Spleen development network (Rhinopithecus roxellana)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

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co-expression

protein homology

Your Input:
	BARX1	BARX homeobox 1. (252 aa)
	CTC1	CST telomere replication complex component 1. (1217 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	SAMD9	Sterile alpha motif domain containing 9. (1525 aa)
	CDH17	Cadherin 17. (832 aa)
	POLB	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa)
	TRAF3IP2	TRAF3 interacting protein 2. (572 aa)
	BCL2L11	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
	NKX3-2	NK3 homeobox 2. (333 aa)
	TCF21	Transcription factor 21. (179 aa)
	NKX2-3	NK2 homeobox 3. (240 aa)
	CDKN2B	Cyclin dependent kinase inhibitor 2B. (138 aa)
	EPB42	Erythrocyte membrane protein band 4.2. (721 aa)
	FLVCR1	Feline leukemia virus subgroup C cellular receptor 1. (555 aa)
	RC3H1	Ring finger and CCCH-type domains 1. (1133 aa)
	NFKB2	Nuclear factor kappa B subunit 2. (899 aa)
	PBX1	PBX homeobox 1. (430 aa)
	ABL1	Tyrosine-protein kinase. (1149 aa)
	SLC40A1	Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (573 aa)
	PKN1	Protein kinase N1. (965 aa)
	RBM15	RNA binding motif protein 15. (977 aa)
	RIPK3	Receptor interacting serine/threonine kinase 3. (518 aa)
	CACNB4	Calcium voltage-gated channel auxiliary subunit beta 4. (520 aa)
	RC3H2	Ring finger and CCCH-type domains 2. (1229 aa)
	NKX2-5	NK2 homeobox 5. (325 aa)
	JARID2	Jumonji and AT-rich interaction domain containing 2. (1246 aa)
	BCL3	BCL3 transcription coactivator. (454 aa)
	PITX2	Homeobox protein. (325 aa)
	BCL2	BCL2 apoptosis regulator. (239 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
	PCID2	PCI domain containing 2. (399 aa)
	PPP2R3C	Protein phosphatase 2 regulatory subunit B''gamma. (453 aa)
	CITED2	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (275 aa)
	ADAM17	ADAM metallopeptidase domain 17. (824 aa)

Your Current Organism:

Rhinopithecus roxellana

NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BARX1	NKX3-2	ENSRROP00000001158	ENSRROP00000016125	BARX homeobox 1.	NK3 homeobox 2.	0.561
BCL2	BCL2L11	ENSRROP00000035252	ENSRROP00000028595	BCL2 apoptosis regulator.	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	0.997
BCL2	FADD	ENSRROP00000035252	ENSRROP00000035006	BCL2 apoptosis regulator.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.492
BCL2	PPP2R3C	ENSRROP00000035252	ENSRROP00000032036	BCL2 apoptosis regulator.	Protein phosphatase 2 regulatory subunit B''gamma.	0.900
BCL2L11	BCL2	ENSRROP00000028595	ENSRROP00000035252	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	BCL2 apoptosis regulator.	0.997
BCL3	NFKB2	ENSRROP00000039119	ENSRROP00000020490	BCL3 transcription coactivator.	Nuclear factor kappa B subunit 2.	0.918
CACNB4	PPP2R3C	ENSRROP00000042013	ENSRROP00000032036	Calcium voltage-gated channel auxiliary subunit beta 4.	Protein phosphatase 2 regulatory subunit B''gamma.	0.654
FADD	BCL2	ENSRROP00000035006	ENSRROP00000035252	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	BCL2 apoptosis regulator.	0.492
FADD	RIPK3	ENSRROP00000035006	ENSRROP00000042191	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Receptor interacting serine/threonine kinase 3.	0.987
NFKB2	BCL3	ENSRROP00000020490	ENSRROP00000039119	Nuclear factor kappa B subunit 2.	BCL3 transcription coactivator.	0.918
NKX2-5	TCF21	ENSRROP00000040051	ENSRROP00000016015	NK2 homeobox 5.	Transcription factor 21.	0.460
NKX3-2	BARX1	ENSRROP00000016125	ENSRROP00000001158	NK3 homeobox 2.	BARX homeobox 1.	0.561
NKX3-2	TCF21	ENSRROP00000016125	ENSRROP00000016015	NK3 homeobox 2.	Transcription factor 21.	0.482
PPP2R3C	BCL2	ENSRROP00000032036	ENSRROP00000035252	Protein phosphatase 2 regulatory subunit B''gamma.	BCL2 apoptosis regulator.	0.900
PPP2R3C	CACNB4	ENSRROP00000032036	ENSRROP00000042013	Protein phosphatase 2 regulatory subunit B''gamma.	Calcium voltage-gated channel auxiliary subunit beta 4.	0.654
RC3H1	RC3H2	ENSRROP00000025606	ENSRROP00000041189	Ring finger and CCCH-type domains 1.	Ring finger and CCCH-type domains 2.	0.588
RC3H2	RC3H1	ENSRROP00000041189	ENSRROP00000025606	Ring finger and CCCH-type domains 2.	Ring finger and CCCH-type domains 1.	0.588
RIPK3	FADD	ENSRROP00000042191	ENSRROP00000035006	Receptor interacting serine/threonine kinase 3.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.987
TCF21	NKX2-5	ENSRROP00000016015	ENSRROP00000040051	Transcription factor 21.	NK2 homeobox 5.	0.460
TCF21	NKX3-2	ENSRROP00000016015	ENSRROP00000016125	Transcription factor 21.	NK3 homeobox 2.	0.482