(42 nodes) Digestive tract morphogenesis network (Rhinopithecus roxellana)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DACT1	Dishevelled binding antagonist of beta catenin 1. (777 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (659 aa)
	BBS7	Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. (715 aa)
	SFRP2	Secreted frizzled related protein 2. (295 aa)
	ID2	Inhibitor of DNA binding 2. (134 aa)
	GLI2	GLI family zinc finger 2. (1586 aa)
	GATA4	GATA binding protein 4. (417 aa)
	HOXA13	Homeobox A13. (219 aa)
	NOTCH1	Notch receptor 1. (2560 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
	SIX2	SIX homeobox 2. (290 aa)
	SFRP1	Secreted frizzled related protein 1. (314 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	STRA6	Stimulated by retinoic acid 6. (706 aa)
	BCL2	BCL2 apoptosis regulator. (239 aa)
	HOXD13	Homeobox D13. (300 aa)
	OVOL2	Ovo like zinc finger 2. (275 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	NODAL	Nodal growth differentiation factor. (347 aa)
	ACVR2B	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (525 aa)
	SMAD2	Mothers against decapentaplegic homolog. (392 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (826 aa)
	GLI1	GLI family zinc finger 1. (1106 aa)
	FGFR2	Fibroblast growth factor receptor. (837 aa)
	SHOX2	Short stature homeobox 2. (355 aa)
	TCF21	Transcription factor 21. (179 aa)
	SHH	HH_signal domain-containing protein. (141 aa)
	HLX	H2.0 like homeobox. (494 aa)
	GLI3	GLI family zinc finger 3. (1580 aa)
	AGR2	Anterior gradient 2, protein disulphide isomerase family member. (175 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	SOX17	SRY-box transcription factor 17. (412 aa)
	NKX2-3	NK2 homeobox 3. (240 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	EPB41L5	Erythrocyte membrane protein band 4.1 like 5. (732 aa)
	SOX10	SRY-box transcription factor 10. (465 aa)
	NIPBL	Nipped-B protein. (2804 aa)
	AHI1	Abelson helper integration site 1. (1196 aa)
	FOXF1	Forkhead box F1. (379 aa)
	SMAD3	Mothers against decapentaplegic homolog. (480 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	EPHB3	EPH receptor B3. (994 aa)

Your Current Organism:

Rhinopithecus roxellana

NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACVR2B	BMP4	ENSRROP00000026676	ENSRROP00000036929	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 4.	0.988
ACVR2B	NODAL	ENSRROP00000026676	ENSRROP00000028644	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Nodal growth differentiation factor.	0.966
ACVR2B	SMAD2	ENSRROP00000026676	ENSRROP00000023441	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic homolog.	0.657
ACVR2B	SMAD3	ENSRROP00000026676	ENSRROP00000006108	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic homolog.	0.611
BCL2	CTNNB1	ENSRROP00000035252	ENSRROP00000030288	BCL2 apoptosis regulator.	Catenin beta 1.	0.493
BCL2	HIF1A	ENSRROP00000035252	ENSRROP00000000494	BCL2 apoptosis regulator.	Hypoxia inducible factor 1 subunit alpha.	0.626
BMP4	ACVR2B	ENSRROP00000036929	ENSRROP00000026676	Bone morphogenetic protein 4.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.988
BMP4	CTNNB1	ENSRROP00000036929	ENSRROP00000030288	Bone morphogenetic protein 4.	Catenin beta 1.	0.421
BMP4	FGF10	ENSRROP00000036929	ENSRROP00000004602	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.568
BMP4	FOXF1	ENSRROP00000036929	ENSRROP00000006271	Bone morphogenetic protein 4.	Forkhead box F1.	0.553
BMP4	GATA4	ENSRROP00000036929	ENSRROP00000041930	Bone morphogenetic protein 4.	GATA binding protein 4.	0.620
BMP4	SHH	ENSRROP00000036929	ENSRROP00000015877	Bone morphogenetic protein 4.	HH_signal domain-containing protein.	0.598
BMP4	SMAD2	ENSRROP00000036929	ENSRROP00000023441	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.634
BMP4	SMAD3	ENSRROP00000036929	ENSRROP00000006108	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.564
BMP4	SOX17	ENSRROP00000036929	ENSRROP00000014953	Bone morphogenetic protein 4.	SRY-box transcription factor 17.	0.407
CTNNB1	BCL2	ENSRROP00000030288	ENSRROP00000035252	Catenin beta 1.	BCL2 apoptosis regulator.	0.493
CTNNB1	BMP4	ENSRROP00000030288	ENSRROP00000036929	Catenin beta 1.	Bone morphogenetic protein 4.	0.421
CTNNB1	DACT1	ENSRROP00000030288	ENSRROP00000004465	Catenin beta 1.	Dishevelled binding antagonist of beta catenin 1.	0.620
CTNNB1	FGFR2	ENSRROP00000030288	ENSRROP00000017546	Catenin beta 1.	Fibroblast growth factor receptor.	0.467
CTNNB1	GLI1	ENSRROP00000030288	ENSRROP00000020996	Catenin beta 1.	GLI family zinc finger 1.	0.524