STRINGSTRING
P2RY6 P2RY6 ID2 ID2 IL6 IL6 ALOX12 ALOX12 S1PR1 S1PR1 MEF2D MEF2D PDGFB PDGFB AKT1 AKT1 SERPINF2 SERPINF2 NPY5R NPY5R TGFBR2 TGFBR2 HTR1B HTR1B ERN1 ERN1 ZNF143 ZNF143 EDN1 EDN1 ELANE ELANE HBEGF HBEGF LOC104657019 LOC104657019 PIK3CA PIK3CA ENSRROP00000013117 ENSRROP00000013117 MAP3K5 MAP3K5 AIF1 AIF1 FOXJ2 FOXJ2 MMP9 MMP9 TERT TERT TLR4 TLR4 MFN2 MFN2 FGFR2 FGFR2 IGF1R IGF1R SRC SRC IGFBP5 IGFBP5 FGF9 FGF9 XBP1 XBP1 ITGB3 ITGB3 CALCRL CALCRL FOXP1 FOXP1 THBS1 THBS1 ENSRROP00000042387 ENSRROP00000042387 IL18 IL18 NOTCH3 NOTCH3 NF1 NF1 CCN4 CCN4 NR4A3 NR4A3 TGFB1 TGFB1 ENSRROP00000039666 ENSRROP00000039666 IRAK1 IRAK1 ITGA2 ITGA2 PDGFRB PDGFRB HMOX1 HMOX1 BMP4 BMP4 CX3CL1 CX3CL1 CYBA CYBA ADAMTS1 ADAMTS1 LDLRAP1 LDLRAP1 RPS6KB1 RPS6KB1 FRS2 FRS2 STAT1 STAT1 PTGS2 PTGS2 DDR2 DDR2 PHB PHB DNMT1 DNMT1 ENSRROP00000029809 ENSRROP00000029809 MMP2 MMP2 ENSRROP00000026787 ENSRROP00000026787 IL6R IL6R IRAK4 IRAK4 NOX1 NOX1 IGF1 IGF1 EREG EREG BMPR1A BMPR1A MNAT1 MNAT1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
P2RY6Pyrimidinergic receptor P2Y6. (328 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
IL6Interleukin 6. (214 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (663 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
MEF2DMyocyte enhancer factor 2D. (521 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
SERPINF2Serpin family F member 2; Belongs to the serpin family. (594 aa)
NPY5RNeuropeptide Y receptor Y5. (445 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
HTR1B5-hydroxytryptamine receptor 1B. (390 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (980 aa)
ZNF143Zinc finger protein 143. (637 aa)
EDN1Endothelin 1. (211 aa)
ELANEElastase, neutrophil expressed; Belongs to the peptidase S1 family. (265 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
LOC104657019Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (396 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ENSRROP00000013117Prohibitin. (179 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1374 aa)
AIF1Allograft inflammatory factor 1. (147 aa)
FOXJ2Forkhead box J2. (574 aa)
MMP9Matrix metallopeptidase 9. (703 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1132 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
MFN2Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (705 aa)
FGFR2Fibroblast growth factor receptor. (837 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
SRCTyrosine-protein kinase. (540 aa)
IGFBP5Insulin like growth factor binding protein 5. (272 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
XBP1BZIP domain-containing protein. (380 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (788 aa)
CALCRLCalcitonin receptor like receptor; Belongs to the G-protein coupled receptor 2 family. (458 aa)
FOXP1Forkhead box P1. (694 aa)
THBS1Thrombospondin 1. (1170 aa)
ENSRROP00000042387BAH domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (691 aa)
IL18Interleukin 18. (211 aa)
NOTCH3Notch receptor 3. (2336 aa)
NF1Neurofibromin 1. (2821 aa)
CCN4Cellular communication network factor 4. (367 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (637 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
ENSRROP00000039666Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (483 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (707 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1151 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
HMOX1Heme oxygenase 1. (303 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (407 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (194 aa)
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif 1. (967 aa)
LDLRAP1Low density lipoprotein receptor adaptor protein 1. (302 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
STAT1Signal transducer and activator of transcription. (787 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (855 aa)
PHBProhibitin. (272 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1665 aa)
ENSRROP00000029809Prohibitin. (264 aa)
MMP2Matrix metallopeptidase 2. (660 aa)
ENSRROP00000026787Prohibitin. (190 aa)
IL6RInterleukin 6 receptor. (468 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
NOX1NADPH oxidase 1. (564 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (208 aa)
EREGEpiregulin. (163 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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