STRINGSTRING
STAT3 STAT3 NRAS NRAS ID1 ID1 FGFR2 FGFR2 AR AR B4GALT1 B4GALT1 TGM1 TGM1 VEGFB VEGFB SIRT6 SIRT6 HIF1A HIF1A ZBED9 ZBED9 PDGFB PDGFB STAT5A STAT5A AKT1 AKT1 NRARP NRARP GHRL GHRL PDPK1 PDPK1 ITGA4 ITGA4 TACR1 TACR1 TP63 TP63 GRN GRN WNT2 WNT2 GDF2 GDF2 JAML JAML NOG NOG PTN PTN GPBAR1 GPBAR1 FGF10 FGF10 AGAP2 AGAP2 NOD2 NOD2 ENSRROP00000005676 ENSRROP00000005676 CRNN CRNN RTN4 RTN4 LAMC1 LAMC1 APLNR APLNR ZNF580 ZNF580 MST1 MST1 F3 F3 NR4A1 NR4A1 TCF7L2 TCF7L2 APELA APELA ST8SIA1 ST8SIA1 OSR1 OSR1 TEK TEK IGF2 IGF2 SP1 SP1 VEGFC VEGFC VEGFD VEGFD BMPR2 BMPR2 WDR48 WDR48 SCN5A SCN5A JCAD JCAD SRSF6 SRSF6 BMP2 BMP2 ECM1 ECM1 SMO SMO ODAM ODAM ATP7A ATP7A PIK3CD PIK3CD LACRT LACRT SPINK1 SPINK1 AGTR1 AGTR1 HYAL1 HYAL1 PRKD1 PRKD1 LOC104668178 LOC104668178 WNT5A WNT5A SHH SHH FGF7 FGF7 MYC MYC BMP6 BMP6 PROX1 PROX1 DLX5 DLX5 EPGN EPGN ARNT ARNT HPN HPN KDM5B KDM5B EMC10 EMC10 ACVRL1 ACVRL1 CCND1 CCND1 IRS2 IRS2 ERBB2 ERBB2 IQGAP3 IQGAP3 APLN APLN IL10 IL10 WNT7A WNT7A ZNF703 ZNF703 PRKCA PRKCA IL18 IL18 NF1 NF1 CCL24 CCL24 VEGFA VEGFA MAP2K5 MAP2K5 NR4A3 NR4A3 NOTCH1 NOTCH1 IHH IHH AREG AREG NKX2-5 NKX2-5 TGFB1 TGFB1 ENSRROP00000039666 ENSRROP00000039666 GATA2 GATA2 ZNF304 ZNF304 CDH3 CDH3 STXBP4 STXBP4 TGFA TGFA HSF4 HSF4 FGF2 FGF2 ENSRROP00000037464 ENSRROP00000037464 SFRP1 SFRP1 HMOX1 HMOX1 BMP4 BMP4 LOC104680991 LOC104680991 EGFR EGFR NKX2-6 NKX2-6 LRG1 LRG1 CYBA CYBA TNFAIP3 TNFAIP3 THBS4 THBS4 MYDGF MYDGF EYA1 EYA1 CLDN1 CLDN1 HRAS HRAS CXCL12 CXCL12 REG3A REG3A VASH2 VASH2 NRP2 NRP2 TNFSF12 TNFSF12 MDK MDK OSR2 OSR2 PLXNB3 PLXNB3 RREB1 RREB1 HTR2B HTR2B CYP7B1 CYP7B1 RESP18 RESP18 HTRA1 HTRA1 EGR3 EGR3 CTNNB1 CTNNB1 PDX1 PDX1 MED1 MED1 HMX2 HMX2 ADAM17 ADAM17 PTPRN PTPRN LOC104682820 LOC104682820 NODAL NODAL NOTCH2 NOTCH2 WNT3A WNT3A RPTOR RPTOR ESRP2 ESRP2 RICTOR RICTOR RUNX2 RUNX2 ENSRROP00000027148 ENSRROP00000027148 SOX9 SOX9 BMP5 BMP5 NRP1 NRP1 IGF1 IGF1 FGFR1 FGFR1 PAX2 PAX2 SEMA5A SEMA5A PPP1R16B PPP1R16B FLT4 FLT4 PLCG1 PLCG1 KDR KDR TGFBR1 TGFBR1 FZD7 FZD7 PKHD1 PKHD1 SAAL1 SAAL1 BMPR1A BMPR1A ENSRROP00000024190 ENSRROP00000024190 CCL26 CCL26 EGF EGF ITGB3 ITGB3 GHSR GHSR REG3G REG3G ENSRROP00000022699 ENSRROP00000022699 XBP1 XBP1 VIP VIP ARG1 ARG1 PRKD2 PRKD2 HLX HLX ENSRROP00000021453 ENSRROP00000021453 C5AR1 C5AR1 AKT3 AKT3 SIRT1 SIRT1 PROK1 PROK1 PGF PGF DLX6 DLX6 FGF9 FGF9 MTA3 MTA3 BAD BAD YAP1 YAP1 BTK BTK FGF1 FGF1 HAS2 HAS2 CCR3 CCR3 MMP12 MMP12
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STAT3Signal transducer and activator of transcription. (802 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (154 aa)
FGFR2Fibroblast growth factor receptor. (837 aa)
ARUncharacterized protein. (523 aa)
B4GALT1Beta-1,4-galactosyltransferase 1. (398 aa)
TGM1Transglutaminase 1. (808 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
SIRT6Sirtuin 6. (355 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
ZBED9Zinc finger BED-type containing 9. (1325 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
STAT5ASignal transducer and activator of transcription. (905 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
NRARPANK_REP_REGION domain-containing protein. (110 aa)
GHRLGhrelin and obestatin prepropeptide. (136 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (356 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
TACR1Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (659 aa)
GRNGranulin precursor. (593 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
GDF2Growth differentiation factor 2. (429 aa)
JAMLUncharacterized protein. (418 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
PTNPleiotrophin. (167 aa)
GPBAR1G protein-coupled bile acid receptor 1. (330 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1196 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1040 aa)
ENSRROP00000005676Nucleoside diphosphate kinase. (152 aa)
CRNNCornulin. (554 aa)
RTN4Reticulon. (1138 aa)
LAMC1Laminin subunit gamma 1. (1608 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
ZNF580Zinc finger protein 580. (172 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. (752 aa)
F3Coagulation factor III, tissue factor. (296 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (670 aa)
TCF7L2Transcription factor 7 like 2. (555 aa)
APELAApelin receptor early endogenous ligand. (54 aa)
ST8SIA1ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (356 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
IGF2Insulin like growth factor 2. (236 aa)
SP1Sp1 transcription factor. (786 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1002 aa)
WDR48WD repeat domain 48. (700 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2016 aa)
JCADJunctional cadherin 5 associated. (1357 aa)
SRSF6Serine and arginine rich splicing factor 6. (343 aa)
BMP2Bone morphogenetic protein 2. (470 aa)
ECM1Extracellular matrix protein 1. (540 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
ODAMOdontogenic, ameloblast associated. (279 aa)
ATP7AUncharacterized protein. (475 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
LACRTLacritin. (137 aa)
SPINK1Serine peptidase inhibitor, Kazal type 1. (79 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (394 aa)
HYAL1Hyaluronidase. (435 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (895 aa)
LOC104668178Uncharacterized protein. (392 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
SHHHH_signal domain-containing protein. (141 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
BMP6Bone morphogenetic protein 6. (439 aa)
PROX1Prospero homeobox 1. (737 aa)
DLX5Distal-less homeobox 5. (289 aa)
EPGNEpithelial mitogen. (154 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (844 aa)
HPNHepsin; Belongs to the peptidase S1 family. (417 aa)
KDM5BLysine demethylase 5B. (1580 aa)
EMC10ER membrane protein complex subunit 10. (346 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (253 aa)
IRS2Insulin receptor substrate 2. (1006 aa)
ERBB2Receptor protein-tyrosine kinase. (1352 aa)
IQGAP3IQ motif containing GTPase activating protein 3. (1632 aa)
APLNApelin. (77 aa)
IL10Interleukin 10. (178 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
ZNF703Zinc finger protein 703. (585 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
IL18Interleukin 18. (211 aa)
NF1Neurofibromin 1. (2821 aa)
CCL24C-C motif chemokine ligand 24. (111 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (637 aa)
NOTCH1Notch receptor 1. (2560 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
AREGAmphiregulin. (274 aa)
NKX2-5NK2 homeobox 5. (325 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
ENSRROP00000039666Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (483 aa)
GATA2GATA binding protein 2. (480 aa)
ZNF304Zinc finger protein 304. (707 aa)
CDH3Cadherin 3; Cadherins are calcium-dependent cell adhesion proteins. (902 aa)
STXBP4Syntaxin binding protein 4. (554 aa)
TGFATransforming growth factor alpha. (166 aa)
HSF4Heat shock transcription factor 4. (492 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (263 aa)
ENSRROP00000037464Uncharacterized protein. (301 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
HMOX1Heme oxygenase 1. (303 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
LOC104680991Uncharacterized protein. (173 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
NKX2-6NK2 homeobox 6. (301 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (347 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (194 aa)
TNFAIP3TNF alpha induced protein 3. (790 aa)
THBS4Thrombospondin 4. (961 aa)
MYDGFMyeloid derived growth factor. (174 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (140 aa)
REG3ARegenerating family member 3 alpha. (175 aa)
VASH2Vasohibin 2. (355 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (930 aa)
TNFSF12TNF superfamily member 12; Belongs to the tumor necrosis factor family. (249 aa)
MDKUncharacterized protein. (143 aa)
OSR2Odd-skipped related transciption factor 2. (423 aa)
PLXNB3Plexin B3. (1919 aa)
RREB1Ras responsive element binding protein 1. (1738 aa)
HTR2B5-hydroxytryptamine receptor 2B. (481 aa)
CYP7B1Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (505 aa)
RESP18Regulated endocrine specific protein 18. (221 aa)
HTRA1HtrA serine peptidase 1. (477 aa)
EGR3Early growth response 3. (387 aa)
CTNNB1Catenin beta 1. (781 aa)
PDX1Pancreatic and duodenal homeobox 1. (283 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1582 aa)
HMX2H6 family homeobox 2. (273 aa)
ADAM17ADAM metallopeptidase domain 17. (824 aa)
PTPRNProtein tyrosine phosphatase receptor type N. (979 aa)
LOC104682820Uncharacterized protein. (143 aa)
NODALNodal growth differentiation factor. (347 aa)
NOTCH2Notch receptor 2. (2471 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1335 aa)
ESRP2Epithelial splicing regulatory protein 2. (711 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1695 aa)
RUNX2RUNX family transcription factor 2. (541 aa)
ENSRROP00000027148Cyclin N-terminal domain-containing protein. (74 aa)
SOX9SRY-box transcription factor 9. (509 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (208 aa)
FGFR1Fibroblast growth factor receptor. (872 aa)
PAX2Paired box 2. (417 aa)
SEMA5ASemaphorin 5A. (1056 aa)
PPP1R16BProtein phosphatase 1 regulatory subunit 16B. (567 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1365 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1303 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (498 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (575 aa)
PKHD1PKHD1 ciliary IPT domain containing fibrocystin/polyductin. (4093 aa)
SAAL1Serum amyloid A like 1. (473 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
ENSRROP00000024190Protein kinase domain-containing protein. (137 aa)
CCL26C-C motif chemokine. (94 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1233 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (788 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
REG3GRegenerating family member 3 gamma. (174 aa)
ENSRROP00000022699Uncharacterized protein. (356 aa)
XBP1BZIP domain-containing protein. (380 aa)
VIPVasoactive intestinal peptide. (170 aa)
ARG1Arginase. (322 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
HLXH2.0 like homeobox. (494 aa)
ENSRROP00000021453Nucleoside diphosphate kinase. (172 aa)
C5AR1Complement C5a receptor 1; Belongs to the G-protein coupled receptor 1 family. (350 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
SIRT1Sirtuin 1. (746 aa)
PROK1Prokineticin 1. (105 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
DLX6Distal-less homeobox 6. (276 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
MTA3Metastasis associated 1 family member 3. (594 aa)
BADBCL2 associated agonist of cell death. (167 aa)
YAP1Yes associated protein 1. (508 aa)
BTKTyrosine-protein kinase. (690 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
HAS2Hyaluronan synthase 2. (460 aa)
CCR3C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (376 aa)
MMP12Matrix metallopeptidase 12. (470 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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