(80 nodes) Regulation of cardiac muscle contraction network (Rhinopithecus roxellana)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	P2RX4	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (404 aa)
	EHD3	EH domain containing 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (544 aa)
	BIN1	Bridging integrator 1. (593 aa)
	CCN2	Cellular communication network factor 2. (387 aa)
	CLIC2	Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (247 aa)
	ASB3	Ankyrin repeat and SOCS box containing 3. (551 aa)
	ATP2A2	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1042 aa)
	GATA4	GATA binding protein 4. (417 aa)
	ENSRROP00000041057	Small ubiquitin-related modifier. (122 aa)
	SMAD7	MH2 domain-containing protein. (211 aa)
	DSG2	Desmoglein 2. (1118 aa)
	NKX2-5	NK2 homeobox 5. (325 aa)
	TMEM38B	Transmembrane protein 38B. (276 aa)
	ASPH	Aspartate beta-hydroxylase. (762 aa)
	KCNQ1	Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (549 aa)
	ANKRD44	Ankyrin repeat domain 44. (985 aa)
	TNNI3	Troponin I3, cardiac type. (211 aa)
	HRC	Histidine rich calcium binding protein. (839 aa)
	ENSRROP00000038566	Rad60-SLD domain-containing protein. (81 aa)
	CALM1	Calmodulin 1. (149 aa)
	STC1	Stanniocalcin 1. (247 aa)
	RYR2	Ryanodine receptor 2. (4938 aa)
	ADRA1A	Adrenoceptor alpha 1A. (455 aa)
	CHGA	Chromogranin A. (453 aa)
	RNF207	Ring finger protein 207. (634 aa)
	BMP10	Bone morphogenetic protein 10. (424 aa)
	TNNI3K	Uncharacterized protein. (901 aa)
	SRI	Sorcin. (198 aa)
	PDE5A	Phosphodiesterase. (875 aa)
	CACNA1C	Ca_chan_IQ domain-containing protein. (829 aa)
	ENSRROP00000028974	Uncharacterized protein. (71 aa)
	DSP	Desmoplakin. (2871 aa)
	ENSRROP00000028305	Uncharacterized protein; Belongs to the calmodulin family. (167 aa)
	LOC104675852	Uncharacterized protein; Belongs to the GST superfamily. (241 aa)
	ZC3H12A	Zinc finger CCCH-type containing 12A. (601 aa)
	ANKRD66	Ankyrin repeat domain 66. (250 aa)
	ENSRROP00000027051	GST C-terminal domain-containing protein. (218 aa)
	ENSRROP00000027041	Uncharacterized protein; Belongs to the calmodulin family. (70 aa)
	DMD	ZZ-type domain-containing protein. (635 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (147 aa)
	JUP	Junction plakoglobin. (760 aa)
	SUMO1	Ubiquitin-like domain-containing protein. (145 aa)
	SLC9A1	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
	ANKRD28	Ankyrin repeat domain 28. (1086 aa)
	ENSRROP00000019822	Uncharacterized protein; Belongs to the calmodulin family. (141 aa)
	ENSRROP00000019711	PDE4_UCR domain-containing protein. (158 aa)
	AKAP9	A-kinase anchoring protein 9. (3861 aa)
	ENSRROP00000019238	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (785 aa)
	CALM3	Calmodulin 1; Belongs to the calmodulin family. (149 aa)
	CALM2	Uncharacterized protein; Belongs to the calmodulin family. (186 aa)
	ADRA1B	Adrenoceptor alpha 1B. (512 aa)
	RANGRF	RAN guanine nucleotide release factor. (186 aa)
	CASQ2	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (400 aa)
	LOC104660236	Uncharacterized protein. (460 aa)
	PIK3CG	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
	GSTO1	Uncharacterized protein; Belongs to the GST superfamily. (241 aa)
	ANK2	Ankyrin 2. (3938 aa)
	DLG1	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (926 aa)
	LOC104671825	Uncharacterized protein. (168 aa)
	FKBP1B	Peptidylprolyl isomerase. (108 aa)
	NOS1	Nitric oxide synthase; Produces nitric oxide (NO). (1184 aa)
	SCN5A	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2016 aa)
	NPPA	Natriuretic peptide A. (153 aa)
	LOC104672524	Uncharacterized protein. (310 aa)
	SLC8A1	Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
	LOC104675649	Uncharacterized protein; Belongs to the GST superfamily. (240 aa)
	GJA5	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
	PDE4D	Phosphodiesterase. (585 aa)
	PLN	Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
	PDE4B	Phosphodiesterase. (564 aa)
	DSC2	Desmocollin 2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (901 aa)
	ENSRROP00000004937	EF-hand domain-containing protein; Belongs to the calmodulin family. (79 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	ATP2A1	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1027 aa)
	ACE2	Angiotensin-converting enzyme. (805 aa)
	SCN10A	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1959 aa)
	TRPM4	Transient receptor potential cation channel subfamily M member 4. (1326 aa)
	PKP2	Plakophilin 2. (882 aa)
	RGS2	Regulator of G protein signaling 2. (211 aa)
	CAMK2D	Calcium/calmodulin dependent protein kinase II delta. (533 aa)

Your Current Organism:

Rhinopithecus roxellana

NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADRA1A	ADRA1B	ENSRROP00000035631	ENSRROP00000019095	Adrenoceptor alpha 1A.	Adrenoceptor alpha 1B.	0.940
ADRA1B	ADRA1A	ENSRROP00000019095	ENSRROP00000035631	Adrenoceptor alpha 1B.	Adrenoceptor alpha 1A.	0.940
AKAP9	CAV3	ENSRROP00000019491	ENSRROP00000004131	A-kinase anchoring protein 9.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.444
AKAP9	KCNQ1	ENSRROP00000019491	ENSRROP00000038955	A-kinase anchoring protein 9.	Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family.	0.908
AKAP9	SCN5A	ENSRROP00000019491	ENSRROP00000010812	A-kinase anchoring protein 9.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.430
ANK2	SCN5A	ENSRROP00000015005	ENSRROP00000010812	Ankyrin 2.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.488
ANKRD28	ANKRD44	ENSRROP00000020098	ENSRROP00000038922	Ankyrin repeat domain 28.	Ankyrin repeat domain 44.	0.634
ANKRD44	ANKRD28	ENSRROP00000038922	ENSRROP00000020098	Ankyrin repeat domain 44.	Ankyrin repeat domain 28.	0.634
ASPH	CASQ2	ENSRROP00000039218	ENSRROP00000016492	Aspartate beta-hydroxylase.	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.972
ASPH	FKBP1B	ENSRROP00000039218	ENSRROP00000012166	Aspartate beta-hydroxylase.	Peptidylprolyl isomerase.	0.692
ASPH	RYR2	ENSRROP00000039218	ENSRROP00000035727	Aspartate beta-hydroxylase.	Ryanodine receptor 2.	0.967
ATP2A1	ATP2A2	ENSRROP00000003799	ENSRROP00000043091	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.907
ATP2A1	PLN	ENSRROP00000003799	ENSRROP00000006245	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.	0.980
ATP2A2	ATP2A1	ENSRROP00000043091	ENSRROP00000003799	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.907
ATP2A2	CASQ2	ENSRROP00000043091	ENSRROP00000016492	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.478
ATP2A2	HRC	ENSRROP00000043091	ENSRROP00000038597	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Histidine rich calcium binding protein.	0.605
ATP2A2	NPPA	ENSRROP00000043091	ENSRROP00000009603	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Natriuretic peptide A.	0.434
ATP2A2	PLN	ENSRROP00000043091	ENSRROP00000006245	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.	0.994
ATP2A2	RYR2	ENSRROP00000043091	ENSRROP00000035727	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Ryanodine receptor 2.	0.628
ATP2A2	SLC8A1	ENSRROP00000043091	ENSRROP00000008051	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	0.471