STRINGSTRING
WNT4 WNT4 SIAH1 SIAH1 CAV1 CAV1 BCL9 BCL9 JUP JUP GATA3 GATA3 ENSRROP00000022699 ENSRROP00000022699 LATS2 LATS2 RSPO3 RSPO3 FZD9 FZD9 RARG RARG WNT8B WNT8B CTDNEP1 CTDNEP1 SOSTDC1 SOSTDC1 DVL3 DVL3 FGF9 FGF9 YAP1 YAP1 DVL2 DVL2 SDC1 SDC1 WNT2B WNT2B WNT9B WNT9B HESX1 HESX1 WNT16 WNT16 SHH SHH EXT1 EXT1 WNT5A WNT5A EDNRB EDNRB WNT10A WNT10A PTEN PTEN WNT9A WNT9A WNT11 WNT11 RECK RECK SFRP5 SFRP5 WNT8A WNT8A TCF7L1 TCF7L1 ISL1 ISL1 EDA EDA FRAT1 FRAT1 TCF7L2 TCF7L2 EDNRA EDNRA EDN1 EDN1 DIXDC1 DIXDC1 RSPO2 RSPO2 ENSRROP00000005643 ENSRROP00000005643 WNT2 WNT2 WNT6 WNT6 FZD5 FZD5 SFRP2 SFRP2 FZD8 FZD8 FZD4 FZD4 EDA-2 EDA-2 WNT1 WNT1 STK3 STK3 GSK3B GSK3B PLPP3 PLPP3 LRP6 LRP6 CDH3 CDH3 FZD3 FZD3 TCF7 TCF7 SFRP1 SFRP1 FOXO1 FOXO1 ENSRROP00000034579 ENSRROP00000034579 FZD10 FZD10 CBY1 CBY1 BCL9L BCL9L LEF1 LEF1 SIAH2 SIAH2 PPP1CA PPP1CA KLF4 KLF4 CTNNB1 CTNNB1 WNT3 WNT3 PYGO2 PYGO2 WNT3A WNT3A RYK RYK PYGO1 PYGO1 LGR4 LGR4 DACT3 DACT3 SOST SOST WNT7A WNT7A WNT7B WNT7B WNT10B WNT10B SFRP4 SFRP4 SCYL2 SCYL2 DKK1 DKK1 AXIN1 AXIN1 DISC1 DISC1 LRP5 LRP5 FZD2 FZD2 FZD7 FZD7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (345 aa)
SIAH1E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (313 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (147 aa)
BCL9BCL9 transcription coactivator. (1426 aa)
JUPJunction plakoglobin. (760 aa)
GATA3GATA binding protein 3. (444 aa)
ENSRROP00000022699Uncharacterized protein. (356 aa)
LATS2Non-specific serine/threonine protein kinase. (1083 aa)
RSPO3R-spondin 3. (293 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (510 aa)
RARGRetinoic acid receptor gamma. (456 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
CTDNEP1CTD nuclear envelope phosphatase 1. (244 aa)
SOSTDC1Sclerostin domain containing 1. (230 aa)
DVL3Dishevelled segment polarity protein 3. (718 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
YAP1Yes associated protein 1. (508 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (325 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
HESX1HESX homeobox 1. (185 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
SHHHH_signal domain-containing protein. (141 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (507 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
RECKReversion inducing cysteine rich protein with kazal motifs. (958 aa)
SFRP5Secreted frizzled related protein 5. (319 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
TCF7L1Transcription factor 7 like 1. (562 aa)
ISL1ISL LIM homeobox 1. (349 aa)
EDAEctodysplasin A; Belongs to the tumor necrosis factor family. (223 aa)
FRAT1FRAT regulator of WNT signaling pathway 1. (242 aa)
TCF7L2Transcription factor 7 like 2. (555 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
EDN1Endothelin 1. (211 aa)
DIXDC1DIX domain containing 1. (683 aa)
RSPO2R-spondin 2. (243 aa)
ENSRROP00000005643Uncharacterized protein. (495 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
FZD8Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (444 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
EDA-2Uncharacterized protein. (147 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
STK3Serine/threonine kinase 3. (519 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (309 aa)
PLPP3acidPPc domain-containing protein. (326 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
CDH3Cadherin 3; Cadherins are calcium-dependent cell adhesion proteins. (902 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
TCF7Transcription factor 7. (469 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
FOXO1Forkhead box O1. (585 aa)
ENSRROP00000034579Uncharacterized protein. (367 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (583 aa)
CBY1Chibby family member 1, beta catenin antagonist. (169 aa)
BCL9LBCL9 like. (1500 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
SIAH2E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (358 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (367 aa)
KLF4Kruppel like factor 4. (479 aa)
CTNNB1Catenin beta 1. (781 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
PYGO2Pygopus family PHD finger 2. (405 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
RYKReceptor like tyrosine kinase. (623 aa)
PYGO1Pygopus family PHD finger 1. (432 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (951 aa)
DACT3Dishevelled binding antagonist of beta catenin 3. (571 aa)
SOSTSclerostin. (213 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (348 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
SFRP4Secreted frizzled related protein 4. (368 aa)
SCYL2SCY1 like pseudokinase 2. (933 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (266 aa)
AXIN1Axin 1. (867 aa)
DISC1DISC1 scaffold protein. (709 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1611 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (571 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (575 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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