STRINGSTRING
COMP COMP PTCH1 PTCH1 ITGB4 ITGB4 CREBBP CREBBP MBNL1 MBNL1 BAK1 BAK1 ECE2 ECE2 ACD ACD GRHL2 GRHL2 RDH10 RDH10 BMP7 BMP7 CHD7 CHD7 SFRP2 SFRP2 BBS7 BBS7 TBX2 TBX2 TP63 TP63 IFT140 IFT140 GDF5 GDF5 NOG NOG FGF10 FGF10 IFT52 IFT52 COL2A1 COL2A1 HNF1A HNF1A PSEN1 PSEN1 RSPO2 RSPO2 SMOC1 SMOC1 EN1 EN1 BAX BAX NIPBL NIPBL ATRX ATRX ZIC3 ZIC3 PCSK5 PCSK5 FGF4 FGF4 IMPAD1 IMPAD1 TULP3 TULP3 KRT84 KRT84 OSR1 OSR1 LOC104680386 LOC104680386 DYNC2H1 DYNC2H1 BMPR2 BMPR2 MEGF8 MEGF8 TBX4 TBX4 MAP3K20 MAP3K20 HOXA11 HOXA11 FERMT2 FERMT2 TMEM107 TMEM107 RECK RECK ALX4 ALX4 KAT2B KAT2B RNF165 RNF165 SKI SKI LOC104666521 LOC104666521 SLC7A11 SLC7A11 HAND2 HAND2 CRABP2 CRABP2 HDAC1 HDAC1 INTU INTU WNT5A WNT5A EXT1 EXT1 SHH SHH HOXD9 HOXD9 DLX5 DLX5 PIAS4 PIAS4 FGFR2 FGFR2 HDAC2 HDAC2 KREMEN1 KREMEN1 RARA RARA PBX1 PBX1 SHOX2 SHOX2 IRF6 IRF6 ENSRROP00000019238 ENSRROP00000019238 ENSRROP00000019405 ENSRROP00000019405 FZD6 FZD6 TFAP2A TFAP2A AFF3 AFF3 MYH3 MYH3 FGF9 FGF9 SP8 SP8 DLX6 DLX6 PRRX1 PRRX1 COL3A1 COL3A1 MED31 MED31 RARG RARG GLI3 GLI3 RSPO4 RSPO4 PITX1 PITX1 MEOX2 MEOX2 HOXA10 HOXA10 SALL1 SALL1 IFT80 IFT80 BMPR1A BMPR1A RAX RAX HOXD10 HOXD10 ZNF358 ZNF358 ITGA6 ITGA6 LRP5 LRP5 C2CD3 C2CD3 TFAP2B TFAP2B PLXNA2 PLXNA2 SALL4 SALL4 FLVCR1 FLVCR1 ZBTB16 ZBTB16 IQCE IQCE DKK1 DKK1 PBX2 PBX2 RUNX2 RUNX2 FRAS1 FRAS1 SLC39A1 SLC39A1 KAT2A KAT2A NOTCH2 NOTCH2 BCL2L11 BCL2L11 CACNA1C CACNA1C PAM PAM WNT3 WNT3 LOC104677352 LOC104677352 FBXW4 FBXW4 ALDH1A2 ALDH1A2 TBX3 TBX3 FREM2 FREM2 ZNF219 ZNF219 MED1 MED1 CTNNB1 CTNNB1 HOXC13 HOXC13 FGF8 FGF8 FOXN1 FOXN1 TBC1D32 TBC1D32 LRP4 LRP4 OSR2 OSR2 TGFB2 TGFB2 WDR19 WDR19 RARB RARB LEF1 LEF1 MSX1 MSX1 HOXA13 HOXA13 LMBR1 LMBR1 ALX3 ALX3 HOXD13 HOXD13 TBX5 TBX5 ECE1 ECE1 CYP26B1 CYP26B1 PRKAB1 PRKAB1 PKDCC PKDCC BMP4 BMP4 PITX2 PITX2 LOC104663799 LOC104663799 MKS1 MKS1 IFT172 IFT172 KDF1 KDF1 CPLANE2 CPLANE2 ASPH ASPH RPGRIP1L RPGRIP1L HOXC10 HOXC10 ENSRROP00000039666 ENSRROP00000039666 KREMEN2 KREMEN2 ENSRROP00000039864 ENSRROP00000039864 HOXD12 HOXD12 IHH IHH NOTCH1 NOTCH1 RC3H2 RC3H2 TAF10 TAF10 SEMA3C SEMA3C IFT122 IFT122 CPLANE1 CPLANE1 WNT7A WNT7A GNA12 GNA12 EVX2 EVX2 SMAD4 SMAD4 FMN1 FMN1 FBN2 FBN2 WDPCP WDPCP HOXC11 HOXC11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
COMPCartilage oligomeric matrix protein. (757 aa)
PTCH1Patched 1. (1448 aa)
ITGB4Integrin beta. (1823 aa)
CREBBPCREB binding protein. (2442 aa)
MBNL1Muscleblind like splicing regulator 1. (399 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
ECE2EEF1AKMT4-ECE2 readthrough. (883 aa)
ACDACD shelterin complex subunit and telomerase recruitment factor. (527 aa)
GRHL2Grainyhead like transcription factor 2. (633 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2998 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
BBS7Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. (715 aa)
TBX2T-box transcription factor 2. (712 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (659 aa)
IFT140Intraflagellar transport 140. (1466 aa)
GDF5Growth differentiation factor 5. (499 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
IFT52Intraflagellar transport 52. (437 aa)
COL2A1Collagen type II alpha 1 chain. (1487 aa)
HNF1AHNF1 homeobox A. (662 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (465 aa)
RSPO2R-spondin 2. (243 aa)
SMOC1SPARC related modular calcium binding 1. (502 aa)
EN1Homeobox protein engrailed-like. (355 aa)
BAXBCL2 associated X, apoptosis regulator. (197 aa)
NIPBLNipped-B protein. (2804 aa)
ATRXUncharacterized protein. (164 aa)
ZIC3Zic family member 3. (466 aa)
PCSK5Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. (1786 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
IMPAD1Inositol monophosphatase domain containing 1. (373 aa)
TULP3TUB like protein 3; Belongs to the TUB family. (482 aa)
KRT84Keratin 84; Belongs to the intermediate filament family. (600 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
LOC104680386Uncharacterized protein. (503 aa)
DYNC2H1Dynein cytoplasmic 2 heavy chain 1. (4150 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1002 aa)
MEGF8Multiple EGF like domains 8. (2834 aa)
TBX4T-box transcription factor 4. (584 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase 20. (800 aa)
HOXA11Homeobox A11. (313 aa)
FERMT2Fermitin family member 2. (695 aa)
TMEM107Transmembrane protein 107. (140 aa)
RECKReversion inducing cysteine rich protein with kazal motifs. (958 aa)
ALX4ALX homeobox 4. (409 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (832 aa)
RNF165Ring finger protein 165. (346 aa)
SKISKI proto-oncogene. (770 aa)
LOC104666521FH2 domain-containing protein. (704 aa)
SLC7A11Solute carrier family 7 member 11. (501 aa)
HAND2Heart and neural crest derivatives expressed 2. (287 aa)
CRABP2Cellular retinoic acid binding protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (138 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (477 aa)
INTUInturned planar cell polarity protein. (942 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
SHHHH_signal domain-containing protein. (141 aa)
HOXD9Homeobox D9. (348 aa)
DLX5Distal-less homeobox 5. (289 aa)
PIAS4Protein inhibitor of activated STAT 4. (529 aa)
FGFR2Fibroblast growth factor receptor. (837 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
KREMEN1Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (484 aa)
RARARetinoic acid receptor alpha. (478 aa)
PBX1PBX homeobox 1. (430 aa)
SHOX2Short stature homeobox 2. (355 aa)
IRF6Interferon regulatory factor 6. (467 aa)
ENSRROP00000019238Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (785 aa)
ENSRROP00000019405Hist_deacetyl domain-containing protein. (352 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
TFAP2ATranscription factor AP-2 alpha. (439 aa)
AFF3AF4/FMR2 family member 3. (1251 aa)
MYH3Myosin heavy chain 3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1904 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
SP8Sp8 transcription factor. (507 aa)
DLX6Distal-less homeobox 6. (276 aa)
PRRX1Paired related homeobox 1. (245 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
MED31Mediator of RNA polymerase II transcription subunit 31; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (131 aa)
RARGRetinoic acid receptor gamma. (456 aa)
GLI3GLI family zinc finger 3. (1580 aa)
RSPO4R-spondin 4. (234 aa)
PITX1Homeobox protein. (314 aa)
MEOX2Mesenchyme homeobox 2. (304 aa)
HOXA10Homeobox A10. (410 aa)
SALL1Spalt like transcription factor 1. (1304 aa)
IFT80Intraflagellar transport 80. (777 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
RAXRetina and anterior neural fold homeobox. (281 aa)
HOXD10Homeobox D10. (340 aa)
ZNF358Zinc finger protein 358. (556 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1130 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1611 aa)
C2CD3C2 domain containing 3 centriole elongation regulator. (2353 aa)
TFAP2BTranscription factor AP-2 beta. (460 aa)
PLXNA2Plexin A2. (1909 aa)
SALL4Spalt like transcription factor 4. (1053 aa)
FLVCR1Feline leukemia virus subgroup C cellular receptor 1. (555 aa)
ZBTB16Zinc finger and BTB domain containing 16. (673 aa)
IQCEIQ motif containing E. (761 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (266 aa)
PBX2PBX homeobox 2. (430 aa)
RUNX2RUNX family transcription factor 2. (541 aa)
FRAS1Fraser extracellular matrix complex subunit 1. (4011 aa)
SLC39A1Solute carrier family 39 member 1. (325 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (806 aa)
NOTCH2Notch receptor 2. (2471 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
CACNA1CCa_chan_IQ domain-containing protein. (829 aa)
PAMPeptidylglycine alpha-amidating monooxygenase. (975 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
LOC104677352Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (484 aa)
FBXW4F-box and WD repeat domain containing 4. (411 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
TBX3T-box transcription factor 3. (743 aa)
FREM2FRAS1 related extracellular matrix 2. (3170 aa)
ZNF219Zinc finger protein 219. (724 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1582 aa)
CTNNB1Catenin beta 1. (781 aa)
HOXC13Homeobox C13. (330 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
FOXN1Forkhead box N1. (648 aa)
TBC1D32TBC1 domain family member 32. (857 aa)
LRP4LDL receptor related protein 4. (1903 aa)
OSR2Odd-skipped related transciption factor 2. (423 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
WDR19WD repeat domain 19. (1342 aa)
RARBRetinoic acid receptor beta. (448 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
MSX1Msh homeobox 1. (261 aa)
HOXA13Homeobox A13. (219 aa)
LMBR1Limb development membrane protein 1; Belongs to the LIMR family. (529 aa)
ALX3ALX homeobox 3. (343 aa)
HOXD13Homeobox D13. (300 aa)
TBX5T-box transcription factor 5. (518 aa)
ECE1Endothelin converting enzyme 1. (858 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
PKDCCProtein kinase domain containing, cytoplasmic. (277 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
PITX2Homeobox protein. (325 aa)
LOC104663799Uncharacterized protein. (246 aa)
MKS1MKS transition zone complex subunit 1. (559 aa)
IFT172Intraflagellar transport 172. (1753 aa)
KDF1Keratinocyte differentiation factor 1. (398 aa)
CPLANE2Ciliogenesis and planar polarity effector 2. (258 aa)
ASPHAspartate beta-hydroxylase. (762 aa)
RPGRIP1LRPGRIP1 like. (1314 aa)
HOXC10Homeobox C10. (342 aa)
ENSRROP00000039666Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (483 aa)
KREMEN2Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (462 aa)
ENSRROP00000039864Homeobox domain-containing protein. (142 aa)
HOXD12Homeobox D12. (270 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
NOTCH1Notch receptor 1. (2560 aa)
RC3H2Ring finger and CCCH-type domains 2. (1229 aa)
TAF10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (218 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (751 aa)
IFT122Intraflagellar transport 122. (1238 aa)
CPLANE1Ciliogenesis and planar polarity effector 1. (3201 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
GNA12G protein subunit alpha 12. (381 aa)
EVX2Even-skipped homeobox 2. (465 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
FMN1Uncharacterized protein. (659 aa)
FBN2Fibrillin 2. (2912 aa)
WDPCPWD repeat containing planar cell polarity effector. (608 aa)
HOXC11Homeobox C11. (304 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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