(14 nodes) Atrial septum morphogenesis network (Rhinopithecus roxellana)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NKX2-5	NK2 homeobox 5. (325 aa)
	HEY2	Hes related family bHLH transcription factor with YRPW motif 2. (309 aa)
	ACVR1	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
	CCN1	Cellular communication network factor 1. (381 aa)
	ISL1	ISL LIM homeobox 1. (349 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1002 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
	NSD2	Nuclear receptor binding SET domain protein 2. (1365 aa)
	NOTCH2	Notch receptor 2. (2471 aa)
	TBX20	T-box transcription factor 20. (447 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	TBX5	T-box transcription factor 5. (518 aa)
	GATA4	GATA binding protein 4. (417 aa)
	ZFPM1	Uncharacterized protein. (143 aa)

Your Current Organism:

Rhinopithecus roxellana

NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACVR1	BMPR2	ENSRROP00000006466	ENSRROP00000010422	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.901
ACVR1	TGFB2	ENSRROP00000006466	ENSRROP00000032840	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.472
BMPR2	ACVR1	ENSRROP00000010422	ENSRROP00000006466	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.901
BMPR2	TGFB2	ENSRROP00000010422	ENSRROP00000032840	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.528
GATA4	HEY2	ENSRROP00000041930	ENSRROP00000005187	GATA binding protein 4.	Hes related family bHLH transcription factor with YRPW motif 2.	0.422
GATA4	ISL1	ENSRROP00000041930	ENSRROP00000010129	GATA binding protein 4.	ISL LIM homeobox 1.	0.499
GATA4	NKX2-5	ENSRROP00000041930	ENSRROP00000040051	GATA binding protein 4.	NK2 homeobox 5.	0.932
GATA4	TBX20	ENSRROP00000041930	ENSRROP00000031053	GATA binding protein 4.	T-box transcription factor 20.	0.757
GATA4	TBX5	ENSRROP00000041930	ENSRROP00000033792	GATA binding protein 4.	T-box transcription factor 5.	0.754
GATA4	ZFPM1	ENSRROP00000041930	ENSRROP00000044069	GATA binding protein 4.	Uncharacterized protein.	0.727
HEY2	GATA4	ENSRROP00000005187	ENSRROP00000041930	Hes related family bHLH transcription factor with YRPW motif 2.	GATA binding protein 4.	0.422
HEY2	NOTCH2	ENSRROP00000005187	ENSRROP00000028089	Hes related family bHLH transcription factor with YRPW motif 2.	Notch receptor 2.	0.440
ISL1	GATA4	ENSRROP00000010129	ENSRROP00000041930	ISL LIM homeobox 1.	GATA binding protein 4.	0.499
ISL1	NKX2-5	ENSRROP00000010129	ENSRROP00000040051	ISL LIM homeobox 1.	NK2 homeobox 5.	0.535
ISL1	TBX20	ENSRROP00000010129	ENSRROP00000031053	ISL LIM homeobox 1.	T-box transcription factor 20.	0.419
ISL1	TBX5	ENSRROP00000010129	ENSRROP00000033792	ISL LIM homeobox 1.	T-box transcription factor 5.	0.423
NKX2-5	GATA4	ENSRROP00000040051	ENSRROP00000041930	NK2 homeobox 5.	GATA binding protein 4.	0.932
NKX2-5	ISL1	ENSRROP00000040051	ENSRROP00000010129	NK2 homeobox 5.	ISL LIM homeobox 1.	0.535
NKX2-5	NSD2	ENSRROP00000040051	ENSRROP00000019849	NK2 homeobox 5.	Nuclear receptor binding SET domain protein 2.	0.612
NKX2-5	TBX20	ENSRROP00000040051	ENSRROP00000031053	NK2 homeobox 5.	T-box transcription factor 20.	0.780