(25 nodes) Cell fate commitment involved in formation of primary germ layer network (Rhinopithecus roxellana)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LEO1	LEO1 homolog, Paf1/RNA polymerase II complex component. (666 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	NODAL	Nodal growth differentiation factor. (347 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	KLF4	Kruppel like factor 4. (479 aa)
	ETS2	Protein C-ets-2; Transcription factor; Belongs to the ETS family. (469 aa)
	EYA1	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	SIX2	SIX homeobox 2. (290 aa)
	ENSRROP00000039864	Homeobox domain-containing protein. (142 aa)
	RTF1	RTF1 homolog, Paf1/RNA polymerase II complex component. (710 aa)
	SMAD1	Mothers against decapentaplegic homolog. (465 aa)
	GATA6	GATA binding protein 6. (548 aa)
	ETV2	ETS variant 2. (342 aa)
	FOXC2	Forkhead box C2. (501 aa)
	SFRP2	Secreted frizzled related protein 2. (295 aa)
	CDC73	Cell division cycle 73. (531 aa)
	PAF1	PAF1 homolog, Paf1/RNA polymerase II complex component. (557 aa)
	EYA2	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (538 aa)
	HOXA11	Homeobox A11. (313 aa)
	TBX6	T-box transcription factor 6. (436 aa)
	SOX17	SRY-box transcription factor 17. (412 aa)
	CTR9	CTR9 homolog, Paf1/RNA polymerase II complex component. (1173 aa)
	EOMES	Eomesodermin. (706 aa)
	PAX2	Paired box 2. (417 aa)

Your Current Organism:

Rhinopithecus roxellana

NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	CTNNB1	ENSRROP00000036929	ENSRROP00000030288	Bone morphogenetic protein 4.	Catenin beta 1.	0.421
BMP4	SMAD1	ENSRROP00000036929	ENSRROP00000038071	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.684
BMP4	SOX17	ENSRROP00000036929	ENSRROP00000014953	Bone morphogenetic protein 4.	SRY-box transcription factor 17.	0.407
BMP4	WNT3A	ENSRROP00000036929	ENSRROP00000027863	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.493
CDC73	CTNNB1	ENSRROP00000002755	ENSRROP00000030288	Cell division cycle 73.	Catenin beta 1.	0.848
CDC73	CTR9	ENSRROP00000002755	ENSRROP00000020471	Cell division cycle 73.	CTR9 homolog, Paf1/RNA polymerase II complex component.	0.999
CDC73	LEO1	ENSRROP00000002755	ENSRROP00000025224	Cell division cycle 73.	LEO1 homolog, Paf1/RNA polymerase II complex component.	0.999
CDC73	PAF1	ENSRROP00000002755	ENSRROP00000006247	Cell division cycle 73.	PAF1 homolog, Paf1/RNA polymerase II complex component.	0.999
CDC73	RTF1	ENSRROP00000002755	ENSRROP00000039557	Cell division cycle 73.	RTF1 homolog, Paf1/RNA polymerase II complex component.	0.996
CTNNB1	BMP4	ENSRROP00000030288	ENSRROP00000036929	Catenin beta 1.	Bone morphogenetic protein 4.	0.421
CTNNB1	CDC73	ENSRROP00000030288	ENSRROP00000002755	Catenin beta 1.	Cell division cycle 73.	0.848
CTNNB1	EOMES	ENSRROP00000030288	ENSRROP00000021146	Catenin beta 1.	Eomesodermin.	0.505
CTNNB1	FOXC2	ENSRROP00000030288	ENSRROP00000001363	Catenin beta 1.	Forkhead box C2.	0.423
CTNNB1	KLF4	ENSRROP00000030288	ENSRROP00000031223	Catenin beta 1.	Kruppel like factor 4.	0.743
CTNNB1	LEO1	ENSRROP00000030288	ENSRROP00000025224	Catenin beta 1.	LEO1 homolog, Paf1/RNA polymerase II complex component.	0.941
CTNNB1	SFRP2	ENSRROP00000030288	ENSRROP00000002446	Catenin beta 1.	Secreted frizzled related protein 2.	0.580
CTNNB1	SMAD1	ENSRROP00000030288	ENSRROP00000038071	Catenin beta 1.	Mothers against decapentaplegic homolog.	0.592
CTNNB1	SOX17	ENSRROP00000030288	ENSRROP00000014953	Catenin beta 1.	SRY-box transcription factor 17.	0.804
CTNNB1	WNT3A	ENSRROP00000030288	ENSRROP00000027863	Catenin beta 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.745
CTR9	CDC73	ENSRROP00000020471	ENSRROP00000002755	CTR9 homolog, Paf1/RNA polymerase II complex component.	Cell division cycle 73.	0.999