(42 nodes) Coronary vasculature development network (Rhinopithecus roxellana)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	PRICKLE1	Prickle planar cell polarity protein 1. (831 aa)
	TBX5	T-box transcription factor 5. (518 aa)
	ARID2	AT-rich interaction domain 2. (1816 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	PDGFRB	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
	ENSRROP00000037464	Uncharacterized protein. (301 aa)
	MMP21	Matrix metallopeptidase 21; Belongs to the peptidase M10A family. (562 aa)
	PTK7	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1078 aa)
	NDST1	N-deacetylase and N-sulfotransferase 1. (882 aa)
	SMAD6	MH2 domain-containing protein. (226 aa)
	NOTCH1	Notch receptor 1. (2560 aa)
	CPLANE1	Ciliogenesis and planar polarity effector 1. (3201 aa)
	APLN	Apelin. (77 aa)
	VEGFB	Vascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
	PLXND1	Plexin D1. (1863 aa)
	GATA6	GATA binding protein 6. (548 aa)
	ENSRROP00000001972	B2-adapt-app_C domain-containing protein. (224 aa)
	SUFU	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (514 aa)
	HEY2	Hes related family bHLH transcription factor with YRPW motif 2. (309 aa)
	APLNR	Apelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
	APELA	Apelin receptor early endogenous ligand. (54 aa)
	ZBTB14	Zinc finger and BTB domain containing 14. (449 aa)
	CNTRL	Centriolin. (2321 aa)
	SETD2	SET domain containing 2, histone lysine methyltransferase. (2563 aa)
	DYNC2H1	Dynein cytoplasmic 2 heavy chain 1. (4150 aa)
	MEGF8	Multiple EGF like domains 8. (2834 aa)
	AP2B1	AP complex subunit beta. (959 aa)
	MYOCD	Myocardin. (973 aa)
	HAND2	Heart and neural crest derivatives expressed 2. (287 aa)
	TGFBR3	Transforming growth factor beta receptor 3. (860 aa)
	ADAMTS6	ADAM metallopeptidase with thrombospondin type 1 motif 6. (1117 aa)
	PRDM1	PR/SET domain 1. (825 aa)
	SRF	Serum response factor. (508 aa)
	MESP1	Mesoderm posterior bHLH transcription factor 1. (270 aa)
	DCTN5	Dynactin subunit 5. (182 aa)
	SEC24B	SEC24 homolog B, COPII coat complex component. (690 aa)
	LRP2	LDL receptor related protein 2. (4655 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (498 aa)
	NRP1	Neuropilin; Belongs to the neuropilin family. (923 aa)
	SGCD	Uncharacterized protein. (102 aa)
	SPRED1	Sprouty related EVH1 domain containing 1. (444 aa)
	GPC3	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (490 aa)

Your Current Organism:

Rhinopithecus roxellana

NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APELA	APLN	ENSRROP00000008716	ENSRROP00000043506	Apelin receptor early endogenous ligand.	Apelin.	0.693
APELA	APLNR	ENSRROP00000008716	ENSRROP00000007129	Apelin receptor early endogenous ligand.	Apelin receptor; Belongs to the G-protein coupled receptor 1 family.	0.935
APLN	APELA	ENSRROP00000043506	ENSRROP00000008716	Apelin.	Apelin receptor early endogenous ligand.	0.693
APLN	APLNR	ENSRROP00000043506	ENSRROP00000007129	Apelin.	Apelin receptor; Belongs to the G-protein coupled receptor 1 family.	0.991
APLNR	APELA	ENSRROP00000007129	ENSRROP00000008716	Apelin receptor; Belongs to the G-protein coupled receptor 1 family.	Apelin receptor early endogenous ligand.	0.935
APLNR	APLN	ENSRROP00000007129	ENSRROP00000043506	Apelin receptor; Belongs to the G-protein coupled receptor 1 family.	Apelin.	0.991
BMP4	SMAD6	ENSRROP00000036929	ENSRROP00000039911	Bone morphogenetic protein 4.	MH2 domain-containing protein.	0.640
BMP4	TGFBR1	ENSRROP00000036929	ENSRROP00000024592	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	0.693
BMP4	TGFBR3	ENSRROP00000036929	ENSRROP00000015337	Bone morphogenetic protein 4.	Transforming growth factor beta receptor 3.	0.425
DCTN5	DYNC2H1	ENSRROP00000023912	ENSRROP00000010321	Dynactin subunit 5.	Dynein cytoplasmic 2 heavy chain 1.	0.536
DYNC2H1	DCTN5	ENSRROP00000010321	ENSRROP00000023912	Dynein cytoplasmic 2 heavy chain 1.	Dynactin subunit 5.	0.536
GATA6	HAND2	ENSRROP00000001281	ENSRROP00000015234	GATA binding protein 6.	Heart and neural crest derivatives expressed 2.	0.553
GATA6	MYOCD	ENSRROP00000001281	ENSRROP00000012508	GATA binding protein 6.	Myocardin.	0.478
GATA6	SRF	ENSRROP00000001281	ENSRROP00000020761	GATA binding protein 6.	Serum response factor.	0.427
GATA6	TBX5	ENSRROP00000001281	ENSRROP00000033792	GATA binding protein 6.	T-box transcription factor 5.	0.412
GPC3	NDST1	ENSRROP00000030283	ENSRROP00000039549	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	N-deacetylase and N-sulfotransferase 1.	0.455
HAND2	GATA6	ENSRROP00000015234	ENSRROP00000001281	Heart and neural crest derivatives expressed 2.	GATA binding protein 6.	0.553
HAND2	MYOCD	ENSRROP00000015234	ENSRROP00000012508	Heart and neural crest derivatives expressed 2.	Myocardin.	0.577
HAND2	TBX5	ENSRROP00000015234	ENSRROP00000033792	Heart and neural crest derivatives expressed 2.	T-box transcription factor 5.	0.627
HEY2	NOTCH1	ENSRROP00000005187	ENSRROP00000040966	Hes related family bHLH transcription factor with YRPW motif 2.	Notch receptor 1.	0.642