STRINGSTRING
FGF18 FGF18 VEGFB VEGFB P2RY6 P2RY6 MIF MIF PDGFB PDGFB ENSRROP00000001806 ENSRROP00000001806 CSF1R CSF1R GPR183 GPR183 BRAF BRAF SERPINF2 SERPINF2 NOD1 NOD1 MAP2K7 MAP2K7 ENSRROP00000003088 ENSRROP00000003088 NPY5R NPY5R CAVIN3 CAVIN3 CCL7 CCL7 TPBG TPBG GPBAR1 GPBAR1 FGF10 FGF10 NOD2 NOD2 CD36 CD36 MT3 MT3 CASR CASR CD4 CD4 LOC104668961 LOC104668961 LOC104674029 LOC104674029 FGF4 FGF4 TNFSF11 TNFSF11 APELA APELA HAVCR2 HAVCR2 HTR2A HTR2A GAREM1 GAREM1 ALKAL2 ALKAL2 CCL19 CCL19 ENSRROP00000009651 ENSRROP00000009651 ENSRROP00000009722 ENSRROP00000009722 TEK TEK MAP3K12 MAP3K12 APOE APOE ENSRROP00000010437 ENSRROP00000010437 ABCA7 ABCA7 BMP2 BMP2 NRXN1 NRXN1 ENSRROP00000011408 ENSRROP00000011408 FGF20 FGF20 SCIMP SCIMP ENSRROP00000011759 ENSRROP00000011759 FERMT2 FERMT2 PTPN22 PTPN22 NTRK1 NTRK1 CCR1 CCR1 ENSRROP00000013117 ENSRROP00000013117 PLA2G5 PLA2G5 RAPGEF2 RAPGEF2 HCRTR1 HCRTR1 DNAJC27 DNAJC27 PDE8A PDE8A CCL17 CCL17 CCL8 CCL8 PTEN PTEN BMPER BMPER CCL14 CCL14 CCL16 CCL16 PTPN11 PTPN11 HAND2 HAND2 DENND2B DENND2B SHC1 SHC1 PDGFA PDGFA TREM2 TREM2 CXCL17 CXCL17 ABL1 ABL1 SPRY2 SPRY2 FGF19 FGF19 CCL20 CCL20 NPTN NPTN TLR4 TLR4 FGFR2 FGFR2 CCL4 CCL4 TNFRSF11A TNFRSF11A CCL21 CCL21 CHI3L1 CHI3L1 FGF1 FGF1 SRC SRC DDTL DDTL CD74 CD74 DDT DDT MAP2K1 MAP2K1 GAREM2 GAREM2 ENSRROP00000021422 ENSRROP00000021422 C5AR1 C5AR1 PTPRC PTPRC PRKD2 PRKD2 LOC104664204 LOC104664204 ITGB3 ITGB3 GPER1 GPER1 CCL26 CCL26 AGER AGER MFHAS1 MFHAS1 F2R F2R KDR KDR FLT4 FLT4 IGF1 IGF1 NRP1 NRP1 LOC104677212 LOC104677212 GCNT2 GCNT2 CCL1 CCL1 PRXL2C PRXL2C ENSRROP00000026787 ENSRROP00000026787 LOC104668962 LOC104668962 ENSRROP00000027305 ENSRROP00000027305 ACKR3 ACKR3 CARD9 CARD9 FGF17 FGF17 TRPV4 TRPV4 NOTCH2 NOTCH2 NDRG4 NDRG4 P2RY1 P2RY1 NODAL NODAL DSTYK DSTYK NRG1 NRG1 SLAMF1 SLAMF1 AKAP12 AKAP12 ENSRROP00000029809 ENSRROP00000029809 CCL23 CCL23 PHB PHB CCR7 CCR7 ERBB4 ERBB4 GLIPR2 GLIPR2 FGF8 FGF8 FGF21 FGF21 FGF23 FGF23 DDR2 DDR2 HTR2B HTR2B MAPK3 MAPK3 LOC104674799 LOC104674799 SLC30A10 SLC30A10 ALKAL1 ALKAL1 GAS6 GAS6 APP APP IL26 IL26 GCG GCG PLA2G2A PLA2G2A PDGFC PDGFC IAPP IAPP FSHR FSHR CD44 CD44 ADRA1A ADRA1A HRAS HRAS FBXW9 FBXW9 TNFAIP8L3 TNFAIP8L3 ENSRROP00000036200 ENSRROP00000036200 OPRM1 OPRM1 EGFR EGFR CX3CL1 CX3CL1 LOC104678227 LOC104678227 FGA FGA CCL13 CCL13 BMP4 BMP4 NELFE NELFE PDGFRB PDGFRB CCL18 CCL18 FGF2 FGF2 NECAB2 NECAB2 CIB1 CIB1 FGFR3 FGFR3 OR2AT4 OR2AT4 FGFR4 FGFR4 PRKCZ PRKCZ PTK2B PTK2B RAP1A RAP1A GPNMB GPNMB FGB FGB SEMA7A SEMA7A PYCARD PYCARD TGFB1 TGFB1 ADCYAP1 ADCYAP1 CRKL CRKL FGG FGG NOTCH1 NOTCH1 S100A7A S100A7A CCL24 CCL24 ANGPT1 ANGPT1 GATA4 GATA4 MTURN MTURN ENSRROP00000042123 ENSRROP00000042123 PRKCA PRKCA ARHGAP8 ARHGAP8 THPO THPO CALCR CALCR RAMP3 RAMP3 FFAR4 FFAR4 CCL22 CCL22 CCN2 CCN2 TIRAP TIRAP RASGRP1 RASGRP1 FBXW7 FBXW7 RIPK2 RIPK2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
P2RY6Pyrimidinergic receptor P2Y6. (328 aa)
MIFUncharacterized protein. (115 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
ENSRROP00000001806G_PROTEIN_RECEP_F1_2 domain-containing protein. (306 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (975 aa)
GPR183G protein-coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (361 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (761 aa)
SERPINF2Serpin family F member 2; Belongs to the serpin family. (594 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (403 aa)
ENSRROP00000003088Uncharacterized protein. (104 aa)
NPY5RNeuropeptide Y receptor Y5. (445 aa)
CAVIN3Caveolae associated protein 3. (293 aa)
CCL7C-C motif chemokine. (99 aa)
TPBGTrophoblast glycoprotein. (420 aa)
GPBAR1G protein-coupled bile acid receptor 1. (330 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1040 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
MT3Metallothionein 3; Belongs to the metallothionein superfamily. Type 1 family. (113 aa)
CASRCalcium sensing receptor. (1088 aa)
CD4CD4 molecule. (458 aa)
LOC104668961SCY domain-containing protein. (114 aa)
LOC104674029Uncharacterized protein. (211 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (317 aa)
APELAApelin receptor early endogenous ligand. (54 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (293 aa)
HTR2A5-hydroxytryptamine receptor 2A. (472 aa)
GAREM1GRB2 associated regulator of MAPK1 subtype 1. (875 aa)
ALKAL2Uncharacterized protein. (60 aa)
CCL19C-C motif chemokine. (98 aa)
ENSRROP00000009651SCY domain-containing protein. (77 aa)
ENSRROP00000009722J domain-containing protein. (272 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
MAP3K12Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (890 aa)
APOEApolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (317 aa)
ENSRROP00000010437Uncharacterized protein. (235 aa)
ABCA7ATP binding cassette subfamily A member 7. (2143 aa)
BMP2Bone morphogenetic protein 2. (470 aa)
NRXN1Neurexin 1. (1507 aa)
ENSRROP00000011408RBD domain-containing protein. (482 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
SCIMPSLP adaptor and CSK interacting membrane protein. (141 aa)
ENSRROP00000011759Uncharacterized protein. (274 aa)
FERMT2Fermitin family member 2. (695 aa)
PTPN22Protein tyrosine phosphatase non-receptor type 22. (813 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
CCR1C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (367 aa)
ENSRROP00000013117Prohibitin. (179 aa)
PLA2G5Phospholipase A(2). (138 aa)
RAPGEF2Rap guanine nucleotide exchange factor 2. (1685 aa)
HCRTR1Hypocretin receptor 1; Belongs to the G-protein coupled receptor 1 family. (425 aa)
DNAJC27J domain-containing protein. (273 aa)
PDE8APhosphodiesterase. (827 aa)
CCL17C-C motif chemokine. (91 aa)
CCL8C-C motif chemokine. (99 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
BMPERBMP binding endothelial regulator. (685 aa)
CCL14C-C motif chemokine. (99 aa)
CCL16C-C motif chemokine. (119 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
HAND2Heart and neural crest derivatives expressed 2. (287 aa)
DENND2BSuppression of tumorigenicity 5. (1137 aa)
SHC1SHC adaptor protein 1. (574 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (169 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
CXCL17C-X-C motif chemokine ligand 17. (119 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
SPRY2Sprouty RTK signaling antagonist 2. (338 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
CCL20C-C motif chemokine. (96 aa)
NPTNNeuroplastin. (398 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
FGFR2Fibroblast growth factor receptor. (837 aa)
CCL4C-C motif chemokine. (92 aa)
TNFRSF11ATNF receptor superfamily member 11a. (595 aa)
CCL21C-C motif chemokine ligand 21. (131 aa)
CHI3L1Chitinase 3 like 1; Belongs to the glycosyl hydrolase 18 family. (405 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
SRCTyrosine-protein kinase. (540 aa)
DDTLD-dopachrome tautomerase like. (121 aa)
CD74CD74 molecule. (294 aa)
DDTUncharacterized protein. (159 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
GAREM2GRB2 associated regulator of MAPK1 subtype 2. (875 aa)
ENSRROP00000021422Uncharacterized protein. (534 aa)
C5AR1Complement C5a receptor 1; Belongs to the G-protein coupled receptor 1 family. (350 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1311 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
LOC104664204SCY domain-containing protein. (102 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (788 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (341 aa)
CCL26C-C motif chemokine. (94 aa)
AGERAdvanced glycosylation end-product specific receptor. (403 aa)
MFHAS1Malignant fibrous histiocytoma amplified sequence 1. (1046 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (425 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1365 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (208 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
LOC104677212Lipoxygenase domain-containing protein. (345 aa)
GCNT2Glucosaminyl (N-acetyl) transferase 2 (I blood group). (402 aa)
CCL1C-C motif chemokine. (96 aa)
PRXL2CUncharacterized protein. (226 aa)
ENSRROP00000026787Prohibitin. (190 aa)
LOC104668962SCY domain-containing protein. (114 aa)
ENSRROP00000027305Protein kinase domain-containing protein. (365 aa)
ACKR3Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (362 aa)
CARD9Caspase recruitment domain family member 9. (536 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (205 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
NOTCH2Notch receptor 2. (2471 aa)
NDRG4NDRG family member 4. (434 aa)
P2RY1Purinergic receptor P2Y1; Belongs to the G-protein coupled receptor 1 family. (373 aa)
NODALNodal growth differentiation factor. (347 aa)
DSTYKDual serine/threonine and tyrosine protein kinase. (755 aa)
NRG1Neuregulin 1. (713 aa)
SLAMF1Signaling lymphocytic activation molecule family member 1. (357 aa)
AKAP12A-kinase anchoring protein 12. (1783 aa)
ENSRROP00000029809Prohibitin. (264 aa)
CCL23C-C motif chemokine. (120 aa)
PHBProhibitin. (272 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (378 aa)
ERBB4Receptor protein-tyrosine kinase. (1280 aa)
GLIPR2GLI pathogenesis related 2; Belongs to the CRISP family. (165 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (855 aa)
HTR2B5-hydroxytryptamine receptor 2B. (481 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
LOC104674799Uncharacterized protein. (97 aa)
SLC30A10Solute carrier family 30 member 10. (485 aa)
ALKAL1ALK and LTK ligand 1. (129 aa)
GAS6Growth arrest specific 6. (701 aa)
APPAmyloid beta precursor protein. (770 aa)
IL26Interleukin 26. (143 aa)
GCGGlucagon. (180 aa)
PLA2G2APhospholipase A(2). (144 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
IAPPIslet amyloid polypeptide. (86 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (695 aa)
CD44CD44 molecule (Indian blood group). (742 aa)
ADRA1AAdrenoceptor alpha 1A. (455 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
FBXW9F-box and WD repeat domain containing 9. (485 aa)
TNFAIP8L3TNF alpha induced protein 8 like 3. (273 aa)
ENSRROP00000036200Uncharacterized protein. (491 aa)
OPRM1Opioid receptor mu 1; Belongs to the G-protein coupled receptor 1 family. (446 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (407 aa)
LOC104678227C-C motif chemokine. (109 aa)
FGAFibrinogen alpha chain. (862 aa)
CCL13C-C motif chemokine. (98 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
NELFENegative elongation factor complex member E. (390 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
CCL18C-C motif chemokine. (88 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (263 aa)
NECAB2N-terminal EF-hand calcium binding protein 2. (303 aa)
CIB1Calcium and integrin binding 1. (191 aa)
FGFR3Fibroblast growth factor receptor. (803 aa)
OR2AT4Olfactory receptor family 2 subfamily AT member 4. (217 aa)
FGFR4Fibroblast growth factor receptor. (802 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (582 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1058 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
GPNMBGlycoprotein nmb. (561 aa)
FGBFibrinogen beta chain. (491 aa)
SEMA7ASemaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (668 aa)
PYCARDPYD and CARD domain containing. (195 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
ADCYAP1Adenylate cyclase activating polypeptide 1. (176 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
FGGFibrinogen gamma chain. (453 aa)
NOTCH1Notch receptor 1. (2560 aa)
S100A7AProtein S100; Belongs to the S-100 family. (101 aa)
CCL24C-C motif chemokine ligand 24. (111 aa)
ANGPT1Angiopoietin 1. (498 aa)
GATA4GATA binding protein 4. (417 aa)
MTURNMaturin, neural progenitor differentiation regulator homolog. (111 aa)
ENSRROP00000042123Uncharacterized protein. (251 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
ARHGAP8Uncharacterized protein. (464 aa)
THPOThrombopoietin. (353 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (489 aa)
RAMP3Receptor activity modifying protein 3. (151 aa)
FFAR4Free fatty acid receptor 4. (377 aa)
CCL22C-C motif chemokine. (93 aa)
CCN2Cellular communication network factor 2. (387 aa)
TIRAPTIR domain containing adaptor protein. (219 aa)
RASGRP1RAS guanyl releasing protein 1. (841 aa)
FBXW7F-box and WD repeat domain containing 7. (707 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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