(17 nodes) NAD+ binding network (Rhinopithecus roxellana)

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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Predicted Interactions

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Your Input:
	HPGD	15-hydroxyprostaglandin dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (266 aa)
	SIRT4	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (314 aa)
	SIRT6	Sirtuin 6. (355 aa)
	ALDH1A3	Aldehyde dehydrogenase 1 family member A3; Belongs to the aldehyde dehydrogenase family. (512 aa)
	LOC104665717	Poly [ADP-ribose] polymerase. (266 aa)
	SIRT5	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...] (310 aa)
	ENSRROP00000016332	Uncharacterized protein. (722 aa)
	HADHA	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha; Belongs to the enoyl-CoA hydratase/isomerase family. (765 aa)
	UXS1	UDP-glucuronate decarboxylase 1. (422 aa)
	SIRT1	Sirtuin 1. (746 aa)
	HADH	Hydroxyacyl-CoA dehydrogenase. (342 aa)
	CRYL1	Crystallin lambda 1. (319 aa)
	SIRT3	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (399 aa)
	EHHADH	Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family. (723 aa)
	PARP14	Poly [ADP-ribose] polymerase. (1800 aa)
	SIRT2	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (370 aa)
	SIRT7	Sirtuin 7. (400 aa)

Your Current Organism:

Rhinopithecus roxellana

NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRYL1	EHHADH	ENSRROP00000025290	ENSRROP00000035416	Crystallin lambda 1.	Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.530
CRYL1	ENSRROP00000016332	ENSRROP00000025290	ENSRROP00000016332	Crystallin lambda 1.	Uncharacterized protein.	0.530
CRYL1	HADHA	ENSRROP00000025290	ENSRROP00000017572	Crystallin lambda 1.	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha; Belongs to the enoyl-CoA hydratase/isomerase family.	0.530
EHHADH	CRYL1	ENSRROP00000035416	ENSRROP00000025290	Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family.	Crystallin lambda 1.	0.530
EHHADH	HADH	ENSRROP00000035416	ENSRROP00000022652	Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family.	Hydroxyacyl-CoA dehydrogenase.	0.614
EHHADH	HADHA	ENSRROP00000035416	ENSRROP00000017572	Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family.	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha; Belongs to the enoyl-CoA hydratase/isomerase family.	0.929
ENSRROP00000016332	CRYL1	ENSRROP00000016332	ENSRROP00000025290	Uncharacterized protein.	Crystallin lambda 1.	0.530
ENSRROP00000016332	HADH	ENSRROP00000016332	ENSRROP00000022652	Uncharacterized protein.	Hydroxyacyl-CoA dehydrogenase.	0.640
HADH	EHHADH	ENSRROP00000022652	ENSRROP00000035416	Hydroxyacyl-CoA dehydrogenase.	Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.614
HADH	ENSRROP00000016332	ENSRROP00000022652	ENSRROP00000016332	Hydroxyacyl-CoA dehydrogenase.	Uncharacterized protein.	0.640
HADH	HADHA	ENSRROP00000022652	ENSRROP00000017572	Hydroxyacyl-CoA dehydrogenase.	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha; Belongs to the enoyl-CoA hydratase/isomerase family.	0.634
HADHA	CRYL1	ENSRROP00000017572	ENSRROP00000025290	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha; Belongs to the enoyl-CoA hydratase/isomerase family.	Crystallin lambda 1.	0.530
HADHA	EHHADH	ENSRROP00000017572	ENSRROP00000035416	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha; Belongs to the enoyl-CoA hydratase/isomerase family.	Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.929
HADHA	HADH	ENSRROP00000017572	ENSRROP00000022652	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha; Belongs to the enoyl-CoA hydratase/isomerase family.	Hydroxyacyl-CoA dehydrogenase.	0.634
SIRT1	SIRT2	ENSRROP00000021023	ENSRROP00000040467	Sirtuin 1.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.607
SIRT1	SIRT3	ENSRROP00000021023	ENSRROP00000025342	Sirtuin 1.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.685
SIRT1	SIRT4	ENSRROP00000021023	ENSRROP00000009678	Sirtuin 1.	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...]	0.526
SIRT1	SIRT6	ENSRROP00000021023	ENSRROP00000000271	Sirtuin 1.	Sirtuin 6.	0.706
SIRT1	SIRT7	ENSRROP00000021023	ENSRROP00000045692	Sirtuin 1.	Sirtuin 7.	0.755
SIRT2	SIRT1	ENSRROP00000040467	ENSRROP00000021023	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	Sirtuin 1.	0.607