STRINGSTRING
WNK4 WNK4 PTCH1 PTCH1 ASXL1 ASXL1 SPRY1 SPRY1 AQP1 AQP1 KLHL3 KLHL3 KANK2 KANK2 FOXC2 FOXC2 EPCAM EPCAM WNT1 WNT1 BASP1 BASP1 BMP7 BMP7 ROBO2 ROBO2 CD34 CD34 WNT6 WNT6 HS3ST3B1 HS3ST3B1 NOG NOG TACSTD2 TACSTD2 WT1 WT1 CTNNBIP1 CTNNBIP1 NPHS2 NPHS2 CITED1 CITED1 PECAM1 PECAM1 TMEM59L TMEM59L SMAD3 SMAD3 HNF1B HNF1B LOC104656641 LOC104656641 AHI1 AHI1 ENSRROP00000006797 ENSRROP00000006797 COMMD5 COMMD5 IRX1 IRX1 EDNRA EDNRA OSR1 OSR1 CD24 CD24 LOC104680386 LOC104680386 IRX2 IRX2 BMP2 BMP2 HOXA11 HOXA11 SMO SMO ADAMTS16 ADAMTS16 HS2ST1 HS2ST1 GZF1 GZF1 DLL1 DLL1 PKD2 PKD2 DLG1 DLG1 CRLF1 CRLF1 WNT11 WNT11 JAG1 JAG1 BMPER BMPER LOC104666521 LOC104666521 EPHA7 EPHA7 EDNRB EDNRB EXT1 EXT1 SHH SHH TCF21 TCF21 GREB1 GREB1 FGFR2 FGFR2 ENSRROP00000017558 ENSRROP00000017558 WNT9B WNT9B RARA RARA PBX1 PBX1 UMOD UMOD KLF15 KLF15 SDC1 SDC1 IRX3 IRX3 FGF1 FGF1 MYO1E MYO1E KIF26B KIF26B PKD1 PKD1 PGF PGF CALB1 CALB1 ARG2 ARG2 SIX1 SIX1 HS3ST3A1 HS3ST3A1 GLI3 GLI3 GATA3 GATA3 SMAD2 SMAD2 HEYL HEYL SIM1 SIM1 LAMA5 LAMA5 SALL1 SALL1 PODXL PODXL WNT4 WNT4 GREB1L GREB1L IQGAP1 IQGAP1 PAX2 PAX2 TFAP2B TFAP2B LAMB2 LAMB2 SLIT2 SLIT2 SMAD5 SMAD5 SOX9 SOX9 MAGI2 MAGI2 NOTCH2 NOTCH2 MTSS1 MTSS1 EPHA4 EPHA4 GPC3 GPC3 CTNNB1 CTNNB1 DSPP DSPP SOX8 SOX8 FGF8 FGF8 NPHS1 NPHS1 DCHS1 DCHS1 RARB RARB LOC104666999 LOC104666999 RET RET BCL2 BCL2 MEF2C MEF2C PROM1 PROM1 EYA1 EYA1 GDF11 GDF11 FOXJ1 FOXJ1 BMP4 BMP4 SFRP1 SFRP1 FGF2 FGF2 SMAD1 SMAD1 CER1 CER1 ENSRROP00000039864 ENSRROP00000039864 SIX2 SIX2 SMAD6 SMAD6 TGFB1 TGFB1 SMAD7 SMAD7 EFNB2 EFNB2 NOTCH1 NOTCH1 LGR4 LGR4 AQP11 AQP11 GDNF GDNF SDC4 SDC4 LZTS2 LZTS2 WNT7B WNT7B SMAD4 SMAD4 FMN1 FMN1 PTPRO PTPRO
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNK4WNK lysine deficient protein kinase 4. (1243 aa)
PTCH1Patched 1. (1448 aa)
ASXL1ASXL transcriptional regulator 1. (1536 aa)
SPRY1Sprouty RTK signaling antagonist 1. (319 aa)
AQP1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa)
KLHL3Kelch like family member 3. (593 aa)
KANK2KN motif and ankyrin repeat domains 2. (851 aa)
FOXC2Forkhead box C2. (501 aa)
EPCAMEpithelial cell adhesion molecule. (318 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
BASP1Brain abundant membrane attached signal protein 1. (227 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
ROBO2Roundabout guidance receptor 2. (1309 aa)
CD34CD34 molecule. (385 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa)
HS3ST3B1Sulfotransferase; Belongs to the sulfotransferase 1 family. (390 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
TACSTD2Tumor associated calcium signal transducer 2. (324 aa)
WT1WT1 transcription factor. (500 aa)
CTNNBIP1Catenin beta interacting protein 1. (81 aa)
NPHS2NPHS2 stomatin family member, podocin. (383 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (219 aa)
PECAM1Platelet and endothelial cell adhesion molecule 1. (756 aa)
TMEM59LTransmembrane protein 59 like. (341 aa)
SMAD3Mothers against decapentaplegic homolog. (480 aa)
HNF1BHNF1 homeobox B. (557 aa)
LOC104656641Uncharacterized protein. (1088 aa)
AHI1Abelson helper integration site 1. (1196 aa)
ENSRROP00000006797COMM domain-containing protein. (263 aa)
COMMD5COMM domain containing 5. (224 aa)
IRX1Iroquois homeobox 1. (480 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
CD24Uncharacterized protein. (127 aa)
LOC104680386Uncharacterized protein. (503 aa)
IRX2Iroquois homeobox 2. (453 aa)
BMP2Bone morphogenetic protein 2. (470 aa)
HOXA11Homeobox A11. (313 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
ADAMTS16ADAM metallopeptidase with thrombospondin type 1 motif 16. (1200 aa)
HS2ST1Heparan sulfate 2-O-sulfotransferase 1. (356 aa)
GZF1GDNF inducible zinc finger protein 1. (717 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (748 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (969 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (926 aa)
CRLF1Cytokine receptor like factor 1. (413 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
BMPERBMP binding endothelial regulator. (685 aa)
LOC104666521FH2 domain-containing protein. (704 aa)
EPHA7EPH receptor A7. (998 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (507 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
SHHHH_signal domain-containing protein. (141 aa)
TCF21Transcription factor 21. (179 aa)
GREB1Growth regulating estrogen receptor binding 1. (1949 aa)
FGFR2Fibroblast growth factor receptor. (837 aa)
ENSRROP00000017558Uncharacterized protein. (78 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
RARARetinoic acid receptor alpha. (478 aa)
PBX1PBX homeobox 1. (430 aa)
UMODUromodulin. (647 aa)
KLF15Kruppel like factor 15. (416 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (325 aa)
IRX3Iroquois homeobox 3. (501 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
MYO1EMyosin IE; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1108 aa)
KIF26BKinesin family member 26B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1952 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4297 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
CALB1Calbindin 1. (261 aa)
ARG2Arginase. (354 aa)
SIX1SIX homeobox 1. (284 aa)
HS3ST3A1Sulfotransferase; Belongs to the sulfotransferase 1 family. (406 aa)
GLI3GLI family zinc finger 3. (1580 aa)
GATA3GATA binding protein 3. (444 aa)
SMAD2Mothers against decapentaplegic homolog. (392 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (328 aa)
SIM1SIM bHLH transcription factor 1. (766 aa)
LAMA5Laminin subunit alpha 5. (3694 aa)
SALL1Spalt like transcription factor 1. (1304 aa)
PODXLPodocalyxin; Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Belongs to the podocalyxin family. (520 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (345 aa)
GREB1LGREB1 like retinoic acid receptor coactivator. (1924 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1696 aa)
PAX2Paired box 2. (417 aa)
TFAP2BTranscription factor AP-2 beta. (460 aa)
LAMB2Laminin subunit beta 2. (1798 aa)
SLIT2Slit guidance ligand 2. (1224 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
SOX9SRY-box transcription factor 9. (509 aa)
MAGI2Membrane associated guanylate kinase, WW and PDZ domain containing 2. (1317 aa)
NOTCH2Notch receptor 2. (2471 aa)
MTSS1MTSS I-BAR domain containing 1. (759 aa)
EPHA4EPH receptor A4. (986 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (490 aa)
CTNNB1Catenin beta 1. (781 aa)
DSPPUncharacterized protein. (1263 aa)
SOX8SRY-box transcription factor 8. (425 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
NPHS1Uncharacterized protein. (1150 aa)
DCHS1Dachsous cadherin-related 1. (3295 aa)
RARBRetinoic acid receptor beta. (448 aa)
LOC104666999Uncharacterized protein. (1010 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1094 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
MEF2CMyocyte enhancer factor 2C. (466 aa)
PROM1Prominin 1. (865 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
GDF11Growth differentiation factor 11. (344 aa)
FOXJ1Forkhead box J1. (386 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (263 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
CER1Cerberus 1, DAN family BMP antagonist. (267 aa)
ENSRROP00000039864Homeobox domain-containing protein. (142 aa)
SIX2SIX homeobox 2. (290 aa)
SMAD6MH2 domain-containing protein. (226 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
SMAD7MH2 domain-containing protein. (211 aa)
EFNB2Ephrin B2; Belongs to the ephrin family. (333 aa)
NOTCH1Notch receptor 1. (2560 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (951 aa)
AQP11Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. (271 aa)
GDNFGlial cell derived neurotrophic factor. (228 aa)
SDC4Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (201 aa)
LZTS2Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (669 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (348 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
FMN1Uncharacterized protein. (659 aa)
PTPROProtein tyrosine phosphatase receptor type O. (1216 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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