STRINGSTRING
ACTC1 ACTC1 SOX9 SOX9 BMPR1A BMPR1A HEYL HEYL SMAD2 SMAD2 NOS3 NOS3 ACVRL1 ACVRL1 ACTA1 ACTA1 SNAI2 SNAI2 WNT5A WNT5A GATA5 GATA5 WNT11 WNT11 HEY1 HEY1 TGFBR2 TGFBR2 TBX2 TBX2 NOG NOG HNF1A HNF1A EXOC4 EXOC4 HEY2 HEY2 SMAD3 SMAD3 FOXF1 FOXF1 ACVR1 ACVR1 TMEM100 TMEM100 MDM4 MDM4 OSR1 OSR1 ISL1 ISL1 ENG ENG BMP2 BMP2 ROBO2 ROBO2 ROBO1 ROBO1 ACTL10 ACTL10 BMP7 BMP7 FOXC2 FOXC2 BMP5 BMP5 SMAD4 SMAD4 TAF10 TAF10 SNAI1 SNAI1 NOTCH1 NOTCH1 ENSRROP00000039666 ENSRROP00000039666 ACTG2 ACTG2 CPLANE2 CPLANE2 MSX1 MSX1 LEF1 LEF1 TGFB2 TGFB2 DCHS1 DCHS1 TBX20 TBX20 FGF8 FGF8 TBX3 TBX3 WNT3A WNT3A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACTC1Actin alpha cardiac muscle 1. (377 aa)
SOX9SRY-box transcription factor 9. (509 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (328 aa)
SMAD2Mothers against decapentaplegic homolog. (392 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
ACTA1Actin alpha 1, skeletal muscle. (351 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
GATA5GATA binding protein 5. (395 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (308 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
TBX2T-box transcription factor 2. (712 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
HNF1AHNF1 homeobox A. (662 aa)
EXOC4Exocyst complex component 4. (974 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (309 aa)
SMAD3Mothers against decapentaplegic homolog. (480 aa)
FOXF1Forkhead box F1. (379 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
TMEM100Transmembrane protein 100. (134 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (490 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
ISL1ISL LIM homeobox 1. (349 aa)
ENGEndoglin. (658 aa)
BMP2Bone morphogenetic protein 2. (470 aa)
ROBO2Roundabout guidance receptor 2. (1309 aa)
ROBO1Roundabout guidance receptor 1. (1651 aa)
ACTL10Actin like 10; Belongs to the actin family. (245 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
FOXC2Forkhead box C2. (501 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
TAF10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (218 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
NOTCH1Notch receptor 1. (2560 aa)
ENSRROP00000039666Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (483 aa)
ACTG2Actin gamma 2, smooth muscle. (376 aa)
CPLANE2Ciliogenesis and planar polarity effector 2. (258 aa)
MSX1Msh homeobox 1. (261 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
DCHS1Dachsous cadherin-related 1. (3295 aa)
TBX20T-box transcription factor 20. (447 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
TBX3T-box transcription factor 3. (743 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.