Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BCL6 | SIRT1 | ENSRROP00000005956 | ENSRROP00000021023 | BCL6 transcription repressor. | Sirtuin 1. | 0.439 |
| BCL6 | TP53 | ENSRROP00000005956 | ENSRROP00000026843 | BCL6 transcription repressor. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.612 |
| BRMS1 | ING2 | ENSRROP00000026204 | ENSRROP00000016318 | BRMS1 transcriptional repressor and anoikis regulator. | Inhibitor of growth protein. | 0.700 |
| DYRK1A | TP53 | ENSRROP00000003471 | ENSRROP00000026843 | Dual specificity tyrosine phosphorylation regulated kinase 1A. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.579 |
| IFNG | SIRT1 | ENSRROP00000017582 | ENSRROP00000021023 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | Sirtuin 1. | 0.471 |
| IFNG | TGFB1 | ENSRROP00000017582 | ENSRROP00000039941 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | Transforming growth factor beta; Belongs to the TGF-beta family. | 0.578 |
| IFNG | TP53 | ENSRROP00000017582 | ENSRROP00000026843 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.495 |
| ING2 | BRMS1 | ENSRROP00000016318 | ENSRROP00000026204 | Inhibitor of growth protein. | BRMS1 transcriptional repressor and anoikis regulator. | 0.700 |
| ING2 | TP53 | ENSRROP00000016318 | ENSRROP00000026843 | Inhibitor of growth protein. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.467 |
| LRRK2 | PINK1 | ENSRROP00000036424 | ENSRROP00000031444 | Leucine rich repeat kinase 2. | PTEN induced kinase 1. | 0.564 |
| NDN | SIRT1 | ENSRROP00000000303 | ENSRROP00000021023 | Necdin, MAGE family member. | Sirtuin 1. | 0.412 |
| NDN | TP53 | ENSRROP00000000303 | ENSRROP00000026843 | Necdin, MAGE family member. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.892 |
| NNMT | SIRT1 | ENSRROP00000025830 | ENSRROP00000021023 | Nicotinamide N-methyltransferase. | Sirtuin 1. | 0.911 |
| PINK1 | LRRK2 | ENSRROP00000031444 | ENSRROP00000036424 | PTEN induced kinase 1. | Leucine rich repeat kinase 2. | 0.564 |
| PINK1 | SIRT1 | ENSRROP00000031444 | ENSRROP00000021023 | PTEN induced kinase 1. | Sirtuin 1. | 0.584 |
| PML | TP53 | ENSRROP00000004128 | ENSRROP00000026843 | Promyelocytic leukemia. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.850 |
| PRKD1 | PRKD2 | ENSRROP00000014118 | ENSRROP00000022147 | Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | 0.953 |
| PRKD2 | PRKD1 | ENSRROP00000022147 | ENSRROP00000014118 | Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | 0.953 |
| RRP8 | SIRT1 | ENSRROP00000044759 | ENSRROP00000021023 | Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] | Sirtuin 1. | 0.915 |
| SIRT1 | BCL6 | ENSRROP00000021023 | ENSRROP00000005956 | Sirtuin 1. | BCL6 transcription repressor. | 0.439 |
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