(17 nodes) Negative regulation of anoikis network (Rhinopithecus roxellana)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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textmining

co-expression

protein homology

Your Input:
	TLE1	TLE family member 1, transcriptional corepressor. (770 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	SNAI2	Snail family transcriptional repressor 2. (268 aa)
	MCL1	MCL1 apoptosis regulator, BCL2 family member. (350 aa)
	SRC	Tyrosine-protein kinase. (540 aa)
	PDK4	Protein-serine/threonine kinase. (411 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (147 aa)
	BCL2L1	BCL2 like 1. (233 aa)
	PTRH2	Peptidyl-tRNA hydrolase 2. (180 aa)
	PIK3R3	Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
	NTRK2	Tyrosine-protein kinase receptor. (838 aa)
	PTK2	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1109 aa)
	BCL2	BCL2 apoptosis regulator. (239 aa)
	CEACAM6	Uncharacterized protein. (344 aa)
	ZNF304	Zinc finger protein 304. (707 aa)
	NOTCH1	Notch receptor 1. (2560 aa)
	ITGA5	Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1098 aa)

Your Current Organism:

Rhinopithecus roxellana

NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL2	BCL2L1	ENSRROP00000035252	ENSRROP00000027448	BCL2 apoptosis regulator.	BCL2 like 1.	0.992
BCL2	MCL1	ENSRROP00000035252	ENSRROP00000018439	BCL2 apoptosis regulator.	MCL1 apoptosis regulator, BCL2 family member.	0.541
BCL2	SRC	ENSRROP00000035252	ENSRROP00000019991	BCL2 apoptosis regulator.	Tyrosine-protein kinase.	0.549
BCL2L1	BCL2	ENSRROP00000027448	ENSRROP00000035252	BCL2 like 1.	BCL2 apoptosis regulator.	0.992
BCL2L1	MCL1	ENSRROP00000027448	ENSRROP00000018439	BCL2 like 1.	MCL1 apoptosis regulator, BCL2 family member.	0.728
CAV1	SRC	ENSRROP00000024200	ENSRROP00000019991	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Tyrosine-protein kinase.	0.949
ITGA5	PTK2	ENSRROP00000045438	ENSRROP00000032850	Integrin subunit alpha 5; Belongs to the integrin alpha chain family.	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.958
ITGA5	SRC	ENSRROP00000045438	ENSRROP00000019991	Integrin subunit alpha 5; Belongs to the integrin alpha chain family.	Tyrosine-protein kinase.	0.932
MCL1	BCL2	ENSRROP00000018439	ENSRROP00000035252	MCL1 apoptosis regulator, BCL2 family member.	BCL2 apoptosis regulator.	0.541
MCL1	BCL2L1	ENSRROP00000018439	ENSRROP00000027448	MCL1 apoptosis regulator, BCL2 family member.	BCL2 like 1.	0.728
NOTCH1	PIK3CA	ENSRROP00000040966	ENSRROP00000011898	Notch receptor 1.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.431
NOTCH1	SRC	ENSRROP00000040966	ENSRROP00000019991	Notch receptor 1.	Tyrosine-protein kinase.	0.421
PIK3CA	NOTCH1	ENSRROP00000011898	ENSRROP00000040966	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	Notch receptor 1.	0.431
PIK3CA	PIK3R3	ENSRROP00000011898	ENSRROP00000030829	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	Phosphoinositide-3-kinase regulatory subunit 3.	0.996
PIK3CA	PTK2	ENSRROP00000011898	ENSRROP00000032850	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.957
PIK3CA	SRC	ENSRROP00000011898	ENSRROP00000019991	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	Tyrosine-protein kinase.	0.967
PIK3R3	PIK3CA	ENSRROP00000030829	ENSRROP00000011898	Phosphoinositide-3-kinase regulatory subunit 3.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.996
PIK3R3	PTK2	ENSRROP00000030829	ENSRROP00000032850	Phosphoinositide-3-kinase regulatory subunit 3.	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.952
PIK3R3	SRC	ENSRROP00000030829	ENSRROP00000019991	Phosphoinositide-3-kinase regulatory subunit 3.	Tyrosine-protein kinase.	0.950
PTK2	ITGA5	ENSRROP00000032850	ENSRROP00000045438	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Integrin subunit alpha 5; Belongs to the integrin alpha chain family.	0.958