STRINGSTRING
TERT TERT PIF1 PIF1 LOC104662872 LOC104662872 NSMCE1 NSMCE1 ZSCAN4 ZSCAN4 TEN1 TEN1 ZBTB10 ZBTB10 SRGAP1 SRGAP1 SMC5 SMC5 DMRT2 DMRT2 RIF1 RIF1 ATRX ATRX TNKS TNKS ZNF827 ZNF827 CTC1 CTC1 STN1 STN1 H3-4 H3-4 ACD ACD RAD51 RAD51 ENSRROP00000000616 ENSRROP00000000616 SIRT6 SIRT6 POT1 POT1 WRN WRN ENSRROP00000036303 ENSRROP00000036303 RNF8 RNF8 TERF2 TERF2 WRAP53 WRAP53 DNA2 DNA2 HDAC2 HDAC2 SAPCD1 SAPCD1 PTGES3 PTGES3 NSMCE4A NSMCE4A WDSUB1 WDSUB1 DHX36 DHX36 LRWD1 LRWD1 ENSRROP00000038417 ENSRROP00000038417 TERB2 TERB2 TERB1 TERB1 PINX1 PINX1 PRKDC PRKDC ZBTB48 ZBTB48 RECQL4 RECQL4 TNKS2 TNKS2 NBN NBN TINF2 TINF2 RTEL1 RTEL1 DCLRE1B DCLRE1B TERF1 TERF1 TERF2IP TERF2IP KDM1A KDM1A UPF1 UPF1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1132 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (703 aa)
LOC104662872Uncharacterized protein. (115 aa)
NSMCE1NSE1 homolog, SMC5-SMC6 complex component. (266 aa)
ZSCAN4Zinc finger and SCAN domain containing 4. (431 aa)
TEN1Uncharacterized protein. (123 aa)
ZBTB10Zinc finger and BTB domain containing 10. (873 aa)
SRGAP1SLIT-ROBO Rho GTPase activating protein 1. (1085 aa)
SMC5SMC_N domain-containing protein. (1102 aa)
DMRT2Doublesex and mab-3 related transcription factor 2. (561 aa)
RIF1Replication timing regulatory factor 1. (2471 aa)
ATRXUncharacterized protein. (164 aa)
TNKSPoly [ADP-ribose] polymerase. (1327 aa)
ZNF827Zinc finger protein 827. (1081 aa)
CTC1CST telomere replication complex component 1. (1217 aa)
STN1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (368 aa)
H3-4Histone H3; Belongs to the histone H3 family. (136 aa)
ACDACD shelterin complex subunit and telomerase recruitment factor. (527 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
ENSRROP00000000616CS domain-containing protein. (136 aa)
SIRT6Sirtuin 6. (355 aa)
POT1Protection of telomeres 1. (634 aa)
WRNWRN RecQ like helicase. (1431 aa)
ENSRROP00000036303TINF2_N domain-containing protein. (363 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (486 aa)
TERF2Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (535 aa)
WRAP53WD repeat containing antisense to TP53. (549 aa)
DNA2DNA replication helicase/nuclease 2. (1061 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
SAPCD1Suppressor APC domain containing 1. (178 aa)
PTGES3CS domain-containing protein. (164 aa)
NSMCE4ANon-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (385 aa)
WDSUB1WD repeat, sterile alpha motif and U-box domain containing 1. (441 aa)
DHX36DEAH-box helicase 36. (1008 aa)
LRWD1Leucine rich repeats and WD repeat domain containing 1. (681 aa)
ENSRROP00000038417Uncharacterized protein. (202 aa)
TERB2Telomere repeat binding bouquet formation protein 2. (221 aa)
TERB1Telomere repeat binding bouquet formation protein 1. (739 aa)
PINX1PIN2 (TERF1) interacting telomerase inhibitor 1. (326 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4159 aa)
ZBTB48Zinc finger and BTB domain containing 48. (688 aa)
RECQL4RecQ like helicase 4. (1150 aa)
TNKS2Poly [ADP-ribose] polymerase. (1166 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (753 aa)
TINF2TINF2_N domain-containing protein. (451 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1299 aa)
DCLRE1BDNA cross-link repair 1B. (532 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (437 aa)
TERF2IPTERF2 interacting protein. (400 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (876 aa)
UPF1UPF1 RNA helicase and ATPase. (1079 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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