(20 nodes) Frizzled cysteine-rich domain superfamily network (Rhinopithecus roxellana)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FZD7	Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (575 aa)
	FZD6	Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
	SFRP5	Secreted frizzled related protein 5. (319 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
	CPZ	Carboxypeptidase Z. (645 aa)
	ROR2	Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (942 aa)
	FZD5	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
	MUSK	Muscle associated receptor tyrosine kinase. (875 aa)
	SFRP2	Secreted frizzled related protein 2. (295 aa)
	FZD8	Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (444 aa)
	FZD4	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
	FRZB	Frizzled related protein. (325 aa)
	SFRP4	Secreted frizzled related protein 4. (368 aa)
	FZD3	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
	SFRP1	Secreted frizzled related protein 1. (314 aa)
	FZD10	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (583 aa)
	MFRP	Membrane frizzled-related protein. (577 aa)
	ROR1	Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (925 aa)
	CORIN	Corin, serine peptidase. (1021 aa)
	FZD2	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (571 aa)

Your Current Organism:

Rhinopithecus roxellana

NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FZD10	FZD3	ENSRROP00000034235	ENSRROP00000038568	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	0.410
FZD10	FZD6	ENSRROP00000034235	ENSRROP00000019458	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family.	0.450
FZD10	ROR1	ENSRROP00000034235	ENSRROP00000033135	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.	Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.	0.938
FZD10	ROR2	ENSRROP00000034235	ENSRROP00000004957	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.	Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.	0.939
FZD10	SFRP1	ENSRROP00000034235	ENSRROP00000037110	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled related protein 1.	0.677
FZD10	SFRP2	ENSRROP00000034235	ENSRROP00000002446	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled related protein 2.	0.650
FZD10	SFRP4	ENSRROP00000034235	ENSRROP00000044543	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled related protein 4.	0.665
FZD10	SFRP5	ENSRROP00000034235	ENSRROP00000012289	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled related protein 5.	0.677
FZD2	FZD3	ENSRROP00000024536	ENSRROP00000038568	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	0.448
FZD2	FZD4	ENSRROP00000024536	ENSRROP00000002265	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family.	0.434
FZD2	FZD6	ENSRROP00000024536	ENSRROP00000019458	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family.	0.461
FZD2	ROR1	ENSRROP00000024536	ENSRROP00000033135	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.	Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.	0.960
FZD2	ROR2	ENSRROP00000024536	ENSRROP00000004957	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.	Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.	0.953
FZD2	SFRP1	ENSRROP00000024536	ENSRROP00000037110	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled related protein 1.	0.820
FZD2	SFRP2	ENSRROP00000024536	ENSRROP00000002446	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled related protein 2.	0.732
FZD2	SFRP4	ENSRROP00000024536	ENSRROP00000044543	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled related protein 4.	0.678
FZD2	SFRP5	ENSRROP00000024536	ENSRROP00000012289	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled related protein 5.	0.706
FZD3	FZD10	ENSRROP00000038568	ENSRROP00000034235	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.	0.410
FZD3	FZD2	ENSRROP00000038568	ENSRROP00000024536	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.	0.448
FZD3	FZD4	ENSRROP00000038568	ENSRROP00000002265	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family.	0.571