(14 nodes) Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily network (Rhinopithecus roxellana)

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Your Input:
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
	PI4KA	Phosphatidylinositol 4-kinase alpha; Belongs to the PI3/PI4-kinase family. (2128 aa)
	ATR	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2578 aa)
	PIK3C2B	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family. (1634 aa)
	PIK3C3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (911 aa)
	PIK3CG	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
	PI4KB	Phosphatidylinositol 4-kinase beta; Belongs to the PI3/PI4-kinase family. (832 aa)
	PIK3C2A	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1686 aa)
	SMG1	SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family. (2596 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
	PRKDC	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4159 aa)

Your Current Organism:

Rhinopithecus roxellana

NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	ATR	ENSRROP00000031543	ENSRROP00000024494	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.996
ATM	MTOR	ENSRROP00000031543	ENSRROP00000025215	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.568
ATM	PRKDC	ENSRROP00000031543	ENSRROP00000044556	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	0.815
ATM	SMG1	ENSRROP00000031543	ENSRROP00000037713	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family.	0.595
ATR	ATM	ENSRROP00000024494	ENSRROP00000031543	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.996
ATR	MTOR	ENSRROP00000024494	ENSRROP00000025215	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.460
MTOR	ATM	ENSRROP00000025215	ENSRROP00000031543	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.568
MTOR	ATR	ENSRROP00000025215	ENSRROP00000024494	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.460
MTOR	PIK3CA	ENSRROP00000025215	ENSRROP00000011898	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.935
MTOR	PIK3CB	ENSRROP00000025215	ENSRROP00000043600	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.935
MTOR	PIK3CD	ENSRROP00000025215	ENSRROP00000012550	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.935
MTOR	PIK3CG	ENSRROP00000025215	ENSRROP00000015553	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family.	0.538
PI4KA	PI4KB	ENSRROP00000024618	ENSRROP00000013415	Phosphatidylinositol 4-kinase alpha; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 4-kinase beta; Belongs to the PI3/PI4-kinase family.	0.969
PI4KA	PIK3C2A	ENSRROP00000024618	ENSRROP00000036346	Phosphatidylinositol 4-kinase alpha; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family.	0.907
PI4KA	PIK3C2B	ENSRROP00000024618	ENSRROP00000022702	Phosphatidylinositol 4-kinase alpha; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family.	0.902
PI4KA	PIK3C3	ENSRROP00000024618	ENSRROP00000031946	Phosphatidylinositol 4-kinase alpha; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.929
PI4KB	PI4KA	ENSRROP00000013415	ENSRROP00000024618	Phosphatidylinositol 4-kinase beta; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 4-kinase alpha; Belongs to the PI3/PI4-kinase family.	0.969
PI4KB	PIK3C2A	ENSRROP00000013415	ENSRROP00000036346	Phosphatidylinositol 4-kinase beta; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family.	0.901
PI4KB	PIK3C2B	ENSRROP00000013415	ENSRROP00000022702	Phosphatidylinositol 4-kinase beta; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family.	0.903
PI4KB	PIK3C3	ENSRROP00000013415	ENSRROP00000031946	Phosphatidylinositol 4-kinase beta; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.938