STRINGSTRING
MAPK13 MAPK13 EGR2 EGR2 CHD4 CHD4 PPP2R5D PPP2R5D ENSRROP00000036200 ENSRROP00000036200 SH3GL3 SH3GL3 HRAS HRAS DNM2 DNM2 RPS6KA5 RPS6KA5 ID4 ID4 RPS6KA2 RPS6KA2 SHC1 SHC1 YWHAB YWHAB MEF2C MEF2C ELK1 ELK1 DOCK3 DOCK3 NAB2 NAB2 FRS2 FRS2 TPH1 TPH1 GRB2 GRB2 RIT2 RIT2 KRAS KRAS NTRK2 NTRK2 AP2A1 AP2A1 MAPK3 MAPK3 RALGDS RALGDS RPS6KA1 RPS6KA1 SGK1 SGK1 DUSP6 DUSP6 PPP2R1A PPP2R1A RALA RALA ADCYAP1R1 ADCYAP1R1 EGR3 EGR3 TCF12 TCF12 MAPK12 MAPK12 LOC104663790 LOC104663790 BDNF BDNF FOS FOS MAPKAPK2 MAPKAPK2 MAPK15 MAPK15 RRAD RRAD ERAS ERAS EP300 EP300 CLTC CLTC ENSRROP00000027305 ENSRROP00000027305 PCSK6 PCSK6 TRIB2 TRIB2 FNDC3B FNDC3B LOC104669594 LOC104669594 KIDINS220 KIDINS220 AP2M1 AP2M1 MAPK14 MAPK14 ENSRROP00000025386 ENSRROP00000025386 PPP2CA PPP2CA PLCG1 PLCG1 FURIN FURIN MAPK1 MAPK1 RIT1 RIT1 DNAL4 DNAL4 RPS6KA3 RPS6KA3 CRK CRK FNDC3A FNDC3A PCSK4 PCSK4 CREB1 CREB1 NAB1 NAB1 ASCL1 ASCL1 PIK3R1 PIK3R1 ENSRROP00000021422 ENSRROP00000021422 ENSRROP00000021314 ENSRROP00000021314 MAP2K1 MAP2K1 DUSP3 DUSP3 SRF SRF JUNB JUNB ID3 ID3 PIK3R2 PIK3R2 CDK5R1 CDK5R1 SHC3 SHC3 DNM1 DNM1 LOC104668539 LOC104668539 F3 F3 REST REST PCSK5 PCSK5 TRIB1 TRIB1 SHC4 SHC4 TIAM1 TIAM1 ADORA2A ADORA2A PPP4R1 PPP4R1 RELCH RELCH NELFB NELFB MAP2K5 MAP2K5 RAPGEF1 RAPGEF1 ENSRROP00000042123 ENSRROP00000042123 EGR1 EGR1 FOSL1 FOSL1 MAPK11 MAPK11 PIK3CB PIK3CB NTRK3 NTRK3 ENSRROP00000044837 ENSRROP00000044837 GRIN2B GRIN2B AP2S1 AP2S1 PTPRS PTPRS PTPRO PTPRO ID2 ID2 MEF2D MEF2D ATF1 ATF1 RHOA RHOA ENSRROP00000010437 ENSRROP00000010437 CREM CREM MEF2A MEF2A ENSRROP00000011408 ENSRROP00000011408 GAB1 GAB1 ENSRROP00000011759 ENSRROP00000011759 AP2B1 AP2B1 PIK3CA PIK3CA CLTA CLTA NTRK1 NTRK1 ENSRROP00000013107 ENSRROP00000013107 LYL1 LYL1 DUSP7 DUSP7 SOS1 SOS1 MAP2K2 MAP2K2 PPP2CB PPP2CB PTPN11 PTPN11 ENSRROP00000001972 ENSRROP00000001972 VRK3 VRK3 NGF NGF BRAF BRAF NTF3 NTF3 FOSB FOSB ENSRROP00000009442 ENSRROP00000009442 ATF2 ATF2 EGR4 EGR4 PPP4R4 PPP4R4 SRC SRC CDK5 CDK5 FRS3 FRS3 PPP2R1B PPP2R1B FYN FYN MAPKAPK3 MAPKAPK3 STAT3 STAT3 NRAS NRAS ID1 ID1 IRS2 IRS2 RALB RALB FNBP4 FNBP4 NTF4 NTF4 DUSP4 DUSP4 ENSRROP00000006154 ENSRROP00000006154 ARC ARC MAPK7 MAPK7 SH3GL2 SH3GL2 CRKL CRKL ADCYAP1 ADCYAP1 AP2A2 AP2A2 CSDE1 CSDE1 RAP1A RAP1A ENSRROP00000038862 ENSRROP00000038862
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK13Mitogen-activated protein kinase. (401 aa)
EGR2Early growth response 2. (476 aa)
CHD4Uncharacterized protein. (1913 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (605 aa)
ENSRROP00000036200Uncharacterized protein. (491 aa)
SH3GL3SH3 domain containing GRB2 like 3, endophilin A3. (286 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (875 aa)
RPS6KA5Non-specific serine/threonine protein kinase. (670 aa)
ID4Inhibitor of DNA binding 4, HLH protein. (153 aa)
RPS6KA2Protein kinase domain-containing protein. (200 aa)
SHC1SHC adaptor protein 1. (574 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
MEF2CMyocyte enhancer factor 2C. (466 aa)
ELK1Uncharacterized protein. (428 aa)
DOCK3Dedicator of cytokinesis 3; Belongs to the DOCK family. (2003 aa)
NAB2NGFI-A binding protein 2. (525 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
TPH1Tryptophan hydroxylase 1. (444 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
RIT2Ras like without CAAX 2. (217 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
AP2A1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (1036 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
RALGDSUncharacterized protein. (919 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
SGK1Non-specific serine/threonine protein kinase. (526 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
RALARAS like proto-oncogene A. (206 aa)
ADCYAP1R1ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family. (524 aa)
EGR3Early growth response 3. (387 aa)
TCF12Transcription factor 12. (706 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
LOC104663790WRNPLPNID domain-containing protein. (925 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (312 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
MAPKAPK2MAPK activated protein kinase 2. (322 aa)
MAPK15Mitogen-activated protein kinase. (544 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
ERASES cell expressed Ras. (233 aa)
EP300E1A binding protein p300. (2413 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1682 aa)
ENSRROP00000027305Protein kinase domain-containing protein. (365 aa)
PCSK6Proprotein convertase subtilisin/kexin type 6; Belongs to the peptidase S8 family. (932 aa)
TRIB2Tribbles pseudokinase 2. (343 aa)
FNDC3BFibronectin type III domain containing 3B. (1204 aa)
LOC104669594Uncharacterized protein. (305 aa)
KIDINS220Kinase D interacting substrate 220. (1777 aa)
AP2M1AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (458 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
ENSRROP00000025386NGF domain-containing protein; Belongs to the NGF-beta family. (182 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1303 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (830 aa)
MAPK1Mitogen-activated protein kinase. (330 aa)
RIT1Ras like without CAAX 1. (236 aa)
DNAL4Dynein light chain. (105 aa)
RPS6KA3Ribosomal protein S6 kinase. (742 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
PCSK4Proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family. (754 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
NAB1NGFI-A binding protein 1. (487 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (234 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
ENSRROP00000021422Uncharacterized protein. (534 aa)
ENSRROP00000021314ETS domain-containing protein. (421 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (185 aa)
SRFSerum response factor. (508 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
ID3Inhibitor of DNA binding 3, HLH protein. (119 aa)
PIK3R2Uncharacterized protein. (647 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (307 aa)
SHC3SHC adaptor protein 3. (546 aa)
DNM1Dynamin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (864 aa)
LOC104668539Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (555 aa)
F3Coagulation factor III, tissue factor. (296 aa)
RESTRE1 silencing transcription factor. (1096 aa)
PCSK5Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. (1786 aa)
TRIB1Tribbles pseudokinase 1. (372 aa)
SHC4SHC adaptor protein 4. (630 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1591 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (409 aa)
PPP4R1Protein phosphatase 4 regulatory subunit 1. (944 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1224 aa)
NELFBNegative elongation factor complex member B. (629 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1265 aa)
ENSRROP00000042123Uncharacterized protein. (251 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (541 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (271 aa)
MAPK11Mitogen-activated protein kinase. (339 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
NTRK3Tyrosine-protein kinase receptor. (864 aa)
ENSRROP00000044837Uncharacterized protein. (457 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
AP2S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (158 aa)
PTPRSProtein tyrosine phosphatase receptor type S. (1865 aa)
PTPROProtein tyrosine phosphatase receptor type O. (1216 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
MEF2DMyocyte enhancer factor 2D. (521 aa)
ATF1Activating transcription factor 1. (270 aa)
RHOARas homolog family member A. (193 aa)
ENSRROP00000010437Uncharacterized protein. (235 aa)
CREMcAMP responsive element modulator. (330 aa)
MEF2AMyocyte enhancer factor 2A. (511 aa)
ENSRROP00000011408RBD domain-containing protein. (482 aa)
GAB1GRB2 associated binding protein 1. (724 aa)
ENSRROP00000011759Uncharacterized protein. (274 aa)
AP2B1AP complex subunit beta. (959 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CLTAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (251 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
ENSRROP00000013107Uncharacterized protein. (128 aa)
LYL1LYL1 basic helix-loop-helix family member. (280 aa)
DUSP7Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (368 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (399 aa)
PPP2CBSerine/threonine-protein phosphatase. (312 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
ENSRROP00000001972B2-adapt-app_C domain-containing protein. (224 aa)
VRK3VRK serine/threonine kinase 3. (488 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (123 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (761 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (264 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)
ENSRROP00000009442Uncharacterized protein. (179 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
EGR4Early growth response 4. (589 aa)
PPP4R4Protein phosphatase 4 regulatory subunit 4. (853 aa)
SRCTyrosine-protein kinase. (540 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
FRS3Fibroblast growth factor receptor substrate 3. (491 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (667 aa)
FYNTyrosine-protein kinase. (537 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (434 aa)
STAT3Signal transducer and activator of transcription. (802 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (154 aa)
IRS2Insulin receptor substrate 2. (1006 aa)
RALBRAS like proto-oncogene B. (206 aa)
FNBP4Formin binding protein 4. (1018 aa)
NTF4Neurotrophin 4; Belongs to the NGF-beta family. (210 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa)
ENSRROP00000006154Uncharacterized protein. (163 aa)
ARCActivity regulated cytoskeleton associated protein. (396 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
SH3GL2SH3 domain containing GRB2 like 2, endophilin A1. (314 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
ADCYAP1Adenylate cyclase activating polypeptide 1. (176 aa)
AP2A2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (943 aa)
CSDE1Cold shock domain containing E1. (844 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
ENSRROP00000038862Protein kinase domain-containing protein. (265 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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