STRINGSTRING
FURIN FURIN MAPK1 MAPK1 LTBP2 LTBP2 TGFBR1 TGFBR1 TGIF1 TGIF1 NEDD8 NEDD8 E2F4 E2F4 EP300 EP300 STUB1 STUB1 LOC104677352 LOC104677352 CCNQ CCNQ XPO1 XPO1 IRX4 IRX4 IRX5 IRX5 CCNT2 CCNT2 CBL CBL UBE2D1 UBE2D1 NCOR1 NCOR1 MAPK3 MAPK3 PPP1CA PPP1CA TGFB2 TGFB2 STAT1 STAT1 ENSRROP00000034135 ENSRROP00000034135 CDK9 CDK9 USP9X USP9X ENSRROP00000035203 ENSRROP00000035203 ARHGEF18 ARHGEF18 ENSRROP00000036234 ENSRROP00000036234 ENSRROP00000036403 ENSRROP00000036403 CDK8 CDK8 TGIF2LX TGIF2LX LTBP1 LTBP1 LDLRAD4 LDLRAD4 ENSRROP00000037750 ENSRROP00000037750 RNF111 RNF111 RBL1 RBL1 PPM1A PPM1A NCOR2 NCOR2 PRKCZ PRKCZ TGFB1 TGFB1 LTBP3 LTBP3 F11R F11R SMAD7 SMAD7 PPP1CC PPP1CC COL1A2 COL1A2 CCNT1 CCNT1 SKIL SKIL ITGA8 ITGA8 ITGB6 ITGB6 SMAD4 SMAD4 ITGB1 ITGB1 BAMBI BAMBI LOC104673417 LOC104673417 NEDD4L NEDD4L SMAD2 SMAD2 ITGB3 ITGB3 PCSK4 PCSK4 ZFYVE9 ZFYVE9 USP9Y USP9Y LOC104666830 LOC104666830 ENSRROP00000021770 ENSRROP00000021770 ITGB5 ITGB5 LOC104661203 LOC104661203 YBX1 YBX1 MYC MYC HDAC1 HDAC1 ENSRROP00000015444 ENSRROP00000015444 RHOA RHOA SKI SKI TFDP1 TFDP1 TRIM33 TRIM33 IRX1 IRX1 WWTR1 WWTR1 JUNB JUNB SMAD3 SMAD3 ENSRROP00000005750 ENSRROP00000005750 ENSRROP00000005625 ENSRROP00000005625 ATP1B4 ATP1B4 MTMR4 MTMR4 UBE2M UBE2M SMURF2 SMURF2 ENSRROP00000000058 ENSRROP00000000058 ITGB8 ITGB8 FKBP1A FKBP1A CDKN2B CDKN2B FBN1 FBN1 RPS27A RPS27A USP15 USP15 PPP1CB PPP1CB ENSRROP00000027060 ENSRROP00000027060 ENSRROP00000026527 ENSRROP00000026527 ENSRROP00000026126 ENSRROP00000026126 MEIS1 MEIS1 LOC104657230 LOC104657230 TGFB3 TGFB3 TGIF2 TGIF2 ITGAV ITGAV ENSRROP00000001728 ENSRROP00000001728 LOC104659073 LOC104659073 LOC104659307 LOC104659307 LOC104657153 LOC104657153 ENSRROP00000003296 ENSRROP00000003296 TGFBR2 TGFBR2 PARD3B PARD3B ENSRROP00000012257 ENSRROP00000012257 MKX MKX CCNK CCNK ENSRROP00000011675 ENSRROP00000011675 PARD3 PARD3 SP1 SP1 IRX2 IRX2 ENSRROP00000009768 ENSRROP00000009768 LTBP4 LTBP4 ENSRROP00000003686 ENSRROP00000003686 PARP1 PARP1 SERPINE1 SERPINE1 MEIS3 MEIS3 IRX6 IRX6 CGN CGN SNW1 SNW1 UBA52 UBA52 TFDP2 TFDP2 E2F5 E2F5 ENSRROP00000019405 ENSRROP00000019405 SMURF1 SMURF1 PARD6A PARD6A IRX3 IRX3 UBC UBC PMEPA1 PMEPA1 CCNC CCNC STRAP STRAP MEN1 MEN1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (830 aa)
MAPK1Mitogen-activated protein kinase. (330 aa)
LTBP2Latent transforming growth factor beta binding protein 2. (1821 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (498 aa)
TGIF1TGFB induced factor homeobox 1. (335 aa)
NEDD8Ubiquitin-like domain-containing protein. (82 aa)
E2F4E2F transcription factor 4. (431 aa)
EP300E1A binding protein p300. (2413 aa)
STUB1STIP1 homology and U-box containing protein 1. (303 aa)
LOC104677352Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (484 aa)
CCNQCyclin Q; Belongs to the cyclin family. (248 aa)
XPO1Exportin 1. (1071 aa)
IRX4Iroquois homeobox 4. (515 aa)
IRX5Iroquois homeobox 5. (483 aa)
CCNT2Cyclin T2; Belongs to the cyclin family. (730 aa)
CBLCbl proto-oncogene. (906 aa)
UBE2D1Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (148 aa)
NCOR1Nuclear receptor corepressor 1. (2440 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (367 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
STAT1Signal transducer and activator of transcription. (787 aa)
ENSRROP00000034135Poly [ADP-ribose] polymerase. (856 aa)
CDK9Cyclin dependent kinase 9; Belongs to the protein kinase superfamily. (372 aa)
USP9XUncharacterized protein. (278 aa)
ENSRROP00000035203Ubiquitin-like domain-containing protein. (141 aa)
ARHGEF18Uncharacterized protein. (1173 aa)
ENSRROP00000036234Peptidylprolyl isomerase. (117 aa)
ENSRROP00000036403PPM-type phosphatase domain-containing protein. (342 aa)
CDK8Cyclin dependent kinase 8; Belongs to the protein kinase superfamily. (464 aa)
TGIF2LXTGFB induced factor homeobox 2 like X-linked. (242 aa)
LTBP1Latent transforming growth factor beta binding protein 1. (1691 aa)
LDLRAD4Low density lipoprotein receptor class A domain containing 4. (306 aa)
ENSRROP00000037750Ubiquitin-like domain-containing protein. (121 aa)
RNF111Ring finger protein 111. (993 aa)
RBL1RB transcriptional corepressor like 1. (1033 aa)
PPM1AProtein phosphatase, Mg2+/Mn2+ dependent 1A. (455 aa)
NCOR2Nuclear receptor corepressor 2. (2522 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (582 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1069 aa)
F11RF11 receptor. (299 aa)
SMAD7MH2 domain-containing protein. (211 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
COL1A2Collagen type I alpha 2 chain. (1366 aa)
CCNT1Cyclin T1; Belongs to the cyclin family. (728 aa)
SKILSKI like proto-oncogene. (684 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1063 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (788 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
LOC104673417Homeobox domain-containing protein. (272 aa)
NEDD4LNEDD4 like E3 ubiquitin protein ligase. (1255 aa)
SMAD2Mothers against decapentaplegic homolog. (392 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (788 aa)
PCSK4Proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family. (754 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1425 aa)
USP9YUbiquitin specific peptidase 9 Y-linked; Belongs to the peptidase C19 family. (2551 aa)
LOC104666830Uncharacterized protein. (286 aa)
ENSRROP00000021770Ubiquitin-like domain-containing protein. (166 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (799 aa)
LOC104661203CSD_1 domain-containing protein. (278 aa)
YBX1CSD_1 domain-containing protein. (324 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (477 aa)
ENSRROP00000015444Peptidylprolyl isomerase. (107 aa)
RHOARas homolog family member A. (193 aa)
SKISKI proto-oncogene. (770 aa)
TFDP1Transcription factor. (410 aa)
TRIM33Tripartite motif containing 33. (1270 aa)
IRX1Iroquois homeobox 1. (480 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
SMAD3Mothers against decapentaplegic homolog. (480 aa)
ENSRROP00000005750Ubiquitin-like domain-containing protein. (77 aa)
ENSRROP00000005625Ubiquitin-like domain-containing protein. (84 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (357 aa)
MTMR4Myotubularin related protein 4. (1195 aa)
UBE2MUbiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family. (183 aa)
SMURF2E3 ubiquitin-protein ligase. (741 aa)
ENSRROP00000000058Uncharacterized protein. (224 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (769 aa)
FKBP1APeptidylprolyl isomerase. (127 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (138 aa)
FBN1Fibrillin 1. (2871 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
USP15Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (981 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (373 aa)
ENSRROP00000027060Uncharacterized protein. (600 aa)
ENSRROP00000026527CYCLIN domain-containing protein; Belongs to the cyclin family. (264 aa)
ENSRROP00000026126Ubiquitin-like domain-containing protein. (77 aa)
MEIS1Meis homeobox 1. (436 aa)
LOC104657230Ubiquitin-like domain-containing protein. (156 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
TGIF2TGFB induced factor homeobox 2. (237 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1048 aa)
ENSRROP00000001728CSD_1 domain-containing protein. (316 aa)
LOC104659073Ubiquitin-like domain-containing protein. (76 aa)
LOC104659307TB domain-containing protein. (166 aa)
LOC104657153Ubiquitin-like domain-containing protein. (128 aa)
ENSRROP00000003296Ubiquitin-like domain-containing protein. (96 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
PARD3BPar-3 family cell polarity regulator beta. (1204 aa)
ENSRROP00000012257Uncharacterized protein. (92 aa)
MKXMohawk homeobox. (352 aa)
CCNKCyclin K; Belongs to the cyclin family. (493 aa)
ENSRROP00000011675Uncharacterized protein. (270 aa)
PARD3Par-3 family cell polarity regulator. (1325 aa)
SP1Sp1 transcription factor. (786 aa)
IRX2Iroquois homeobox 2. (453 aa)
ENSRROP00000009768Uncharacterized protein. (260 aa)
LTBP4Latent transforming growth factor beta binding protein 4. (1583 aa)
ENSRROP00000003686Ubiquitin-like domain-containing protein. (81 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (444 aa)
MEIS3Meis homeobox 3. (446 aa)
IRX6Iroquois homeobox 6. (444 aa)
CGNMyosin_tail_1 domain-containing protein. (1210 aa)
SNW1SNW domain containing 1. (536 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
TFDP2Transcription factor. (447 aa)
E2F5E2F transcription factor 5. (345 aa)
ENSRROP00000019405Hist_deacetyl domain-containing protein. (352 aa)
SMURF1E3 ubiquitin-protein ligase. (764 aa)
PARD6APar-6 family cell polarity regulator alpha. (344 aa)
IRX3Iroquois homeobox 3. (501 aa)
UBCUncharacterized protein. (351 aa)
PMEPA1Prostate transmembrane protein, androgen induced 1. (257 aa)
CCNCCyclin C; Belongs to the cyclin family. (283 aa)
STRAPSerine/threonine kinase receptor associated protein. (363 aa)
MEN1Menin 1. (610 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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